Serum soluble Fas levels and coronary artery disease in hemodialysis patients

Detection of apoptosis in patients with coronary artery disease : Assessment of temporal patterns and potential sources

“…Interestingly, aggressive Atorvastatin treatment diminished sFas levels pointing to the connection of apoptosis with inflammation [97]. Elevated sFas is also linked to the extent of coronary artery disease in patients with renal failure [98]. SFasL on the other hand, has emerged as a possible atheroprotective marker [99].…”

“…Soluble forms of Fas and FasL have been shown to be positively associated with NK cell levels in NK cell proliferative disorders [197,62] as well as with circulating levels of apoptotic NK and T cells in autoimmune and neoplastic disorders [198][199][200]. In CVD, as mentioned above, high levels of sFas point to an increased risk whereas increased sFasL seems to represent the opposite [96][97][98][99][100]. In most of the referred studies however, blood samples were drawn only at one occasion making verdicts on correlation changes over time impossible.…”