Serum soluble CD44 levels for monitoring disease states in acute leukemia and myelodysplastic syndromes.

Nasu, Hidekazu; Hibi, Nozomu; Ohyashiki, J H; Hara, Akinori; Kubono, Kazushige; Tsukada, Yoshito; Ando, Kazunori; Iwama, Hiroshi; Hayashi, Shigehiro; Yahata, Naoyuki; Toyama, Kazuhiro; Ohyashiki, Kazuma

doi:10.3892/ijo.13.3.525

Cited by 13 publications

(9 citation statements)

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“…Neither sCD44-v6 nor sCD44-v5 was increased in B-CLL (32). In addition, the sCD44st level is signi®cantly increased in AML, acute lymphoid leukemia (ALL) and chronic myeloid leukemia (CML), and decreases to the normal range in AML or ALL when CR is achieved (33).…”

Section: Discussionmentioning

confidence: 99%

Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non‐Hodgkin's lymphoma

Sasaki

Niitsu

2000

European J of Haematology

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A variant form of CD44 that has additional amino acids in the common protein backbone (CD44-v6) seems to play a role in the metastasis of malignancies. We measured soluble CD44-v6 (sCD44-v6) by ELISA in 201 patients with malignant lymphoma. The sCD44-v6 level was significantly elevated in patients with non-Hodgkin's lymphoma (NHL) (n = 184). The sCD44-v6 level was correlated significantly with the standard sCD44 and soluble interleukin-2 receptor levels, but only weakly with serum lactate dehydrogenase (LDH). In 149 patients with aggressive NHL, the sCD44-v6 level was elevated in the subgroups with a high LDH level, stage III/IV disease, T-cell lymphoma, and high-intermediate or high risk group as identified by the International Prognostic Index (IPI). When the sCD44-v6 level was > or = 800 ng/ml the overall survival rate was significantly decreased (p = 0.0001). In the low + low-intermediate risk group (IPI) both overall survival rates (log-rank p = 0.0005, Wilcoxon p =0.002) were significantly decreased when the sCD44-v6 level was > or = 800 ng/ml. In multivariate analysis, sCD44-v6 was shown to be independent of the five prognostic factors in the IPI (age, performance status, number of extranodal sites, Ann Arbor stage and LDH level), so it may be useful for predicting the outcome of aggressive NHL.

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Section: Discussionmentioning

confidence: 99%

Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non‐Hodgkin's lymphoma

Sasaki

Niitsu

2000

European J of Haematology

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“…38 This fusion gene has been shown to alter the splicing of CD44 mRNA, 39 whose splice variants have been implicated in tumor progression. 40 In addition, this fusion protein was shown to initiate leukemogenesis in normal hematopoietic cells, 41 suggesting that a defect in the splicing machinery can affect the expression of genes involved in leukemogenesis and perhaps in sensitivity to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

Veuger

Heemskerk

Honders

et al. 2002

Blood

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Development of resistance to cytarabine (AraC) is a major problem in the treatment of patients with acute myeloid leukemia (AML). Inactivation of deoxycytidine kinase (dCK) plays an important role in AraC resistance in vitro. We have identified inactive, alternatively spliced dCK forms in leukemic blasts from patients with resistant AML. Because these dCKspliced variants were only detectable in resistant AML, it was hypothesized that they might play a role in AraC resistance in vivo. In the current study, the biologic role of the alternatively spliced dCK forms in AraC resistance was further investi-

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“…Serum CD44 levels may be of value as markers in some malignant tumors and are regarded as useful in the detection of non‐Hodgkin lymphoma 20, in monitoring acute 21 and chronic lymphocytic leukemia 22, and cervical cancer 23. In contrast, serum CD44 levels were reported to be of no or little value in patients with breast and colorectal carcinoma 20.…”

Section: Discussionmentioning

confidence: 99%

Are serum levels of CD44 relevant in children with pediatric sarcomas?

Kebudi

Ayan

Yasasever

et al. 2005

Pediatr. Blood Cancer

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Serum soluble CD44 levels for monitoring disease states in acute leukemia and myelodysplastic syndromes.

Cited by 13 publications

References 0 publications

Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non‐Hodgkin's lymphoma

Elevated serum levels of soluble CD44 variant 6 are correlated with shorter survival in aggressive non‐Hodgkin's lymphoma

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

Are serum levels of CD44 relevant in children with pediatric sarcomas?

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