Serum Serotonin as a Biomarker of the Efficacy of PAP-Therapy in Sleep Apnea Syndrome

Мадаева, Ирина; Ухинов, Э. Б.; Курашова, Н. А.; Semenova, Natalya; Bairova, T. A.; Bel’skikh, A. V.; Natyaganova, L. V.; Колесников, С. И.; Колесникова, Л. И.

doi:10.1007/s10517-021-05301-5

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Interestingly, the FSSQ has a sequence of questions concerning sleep apnea and snoring, which are relevant for assessing respiratoryrelated sleep alterations. Despite we did not detect OSA by HSAT, it was demonstrated that treatment of OSA by 3-month positive air pressure therapy (PAP) resulted in an enhancement of serum serotonin levels [34]. Considering the many roles of serotonin it is possible to conclude that low levels of serotonin might be linked with other changes seen in DFD patients besides sleep alterations, such as anxiety and depression.…”

Section: Discussionmentioning

confidence: 76%

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

Bisatto,

Crescente,

Fritscher

et al. 2024

Preprint

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Introduction It has been suggested that dentofacial deformities (DFD) can impair sleep quality. This pilot study aimed at evaluating sleep disorders in individuals with DFD before orthognathic surgery, correlating the clinical findings with salivary biomarker levels. Materials and Methods This cross-sectional study enrolled ten males and ten females with DFD diagnoses under orthodontic treatment preceding orthognathic surgery. The participants responded to the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), and the Fletcher and Luckett Sleep Questionnaire (FLSQ). Obstructive sleep apnea (OSA) was examined by the Home Sleep Apnea Test (HSAT). The salivary levels of interleukin-1β (IL-1β), glutamate, and serotonin were measured. Results Eighty-five% of individuals presented PSQI and FLSQ scores indicative of sleep alterations. Females had higher scores in part 2 of the FLSQ instrument, referring to sleepiness-associated complaints. HSAT analysis revealed a low number of symptomatic OSA individuals, with three males demonstrating altered oxygen desaturation rates. There was a significant negative correlation between the salivary levels of serotonin and the FLSQ results. Discussion Individuals with DFD diagnosis showed poorer sleep quality, which is likely independent of sex and OSA diagnosis, and negatively correlated with salivary levels of serotonin.

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Section: Discussionmentioning

confidence: 76%

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

Bisatto,

Crescente,

Fritscher

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Focusing on biomarkers like neurotransmitters such as serotonin (5-HT), which are crucial for health evaluation, , we developed our approach for the precise identification of target molecules. Serotonin plays an important roles in diseases − affecting the cardiovascular system, − causing carcinoid tumors, , or triggering diabetes mellitus. − Research indicates that breast cancer cells release serotonin at concentrations of over 400 nM, which is 3 times higher than in normal cells . Lower 5-HT levels were also observed (about 5–10 nM) for type 2 diabetes .…”

Section: Introductionmentioning

confidence: 99%

Minimizing False Positives in Gold Nanoparticle–Aptamer Biosensors for Enhanced Serotonin Detection

Tran,

Pham,

Tran

et al. 2024

ACS Appl. Nano Mater.

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, an essential neurotransmitter, regulates numerous physiological processes in the human body. Imbalances in 5-HT levels contribute to various health conditions, including neurodegenerative diseases, depression, diabetes mellitus, and serotonin syndrome. 5-HT also functions as a growth factor for tumor cells, influencing various stages of tumor development.Measuring 5-HT concentrations in biological fluids such as blood and serum could facilitate early diagnosis of these conditions. Traditional label-free colorimetric aptasensors often struggle to detect small molecules due to false positives from nonspecific interactions with gold nanoparticles (AuNPs). To address this issue, we propose a novel colorimetric sensing method for specific serotonin detection by eliminating nonspecific AuNP interactions. By incorporating a complementary aptamer hybridization step, our label-free aptamer-based method can selectively detect serotonin while avoiding nonspecific AuNP interactions. We optimized detection conditions and established a calibration curve for 5-HT detection, achieving a limit of detection (LOD) of 2.2 nM. Our method shows high selectivity and sensitivity, even for structurally similar compounds such as dopamine and tryptophan. It successfully quantifies 5-HT directly in complex biological samples with minimal preparation, achieving average recoveries between 92 and 108% (RSD: 9.5−12.9%; n = 5). This label-free aptamer-based approach shows promise for the reliable detection of 5-HT and other small molecules in real biological samples.

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Changes in Relative Telomere Length in Patients with Obstructive Sleep Apnea Syndrome on the Background of CPAP Therapy: A Pilot Study

Мадаева

Курашова

Ухинов

et al. 2023

Neurosci Behav Physi

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Serum Serotonin as a Biomarker of the Efficacy of PAP-Therapy in Sleep Apnea Syndrome

Cited by 4 publications

References 11 publications

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

Sleep disorders in individuals with dentofacial deformities: a preliminary study on the relationship with sex and serotonin levels

Minimizing False Positives in Gold Nanoparticle–Aptamer Biosensors for Enhanced Serotonin Detection

Changes in Relative Telomere Length in Patients with Obstructive Sleep Apnea Syndrome on the Background of CPAP Therapy: A Pilot Study

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