Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

Yang, Sae Jeong; Hwang, Soon Young; Choi, Hee Youn; Yoo, Hye Jin; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook

doi:10.1210/jc.2011-0620

Cited by 166 publications

(130 citation statements)

References 18 publications

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“…However, our data indicate that treatment with purified SeP directly inhibits angiogenesis in both vascular endothelial cells and mice on euglycemic conditions. Combined with the previous reports showing the elevated production of SeP in type 2 diabetes [15,16], the current data suggest that overproduction of SeP contributes to the onset of impaired angiogenesis in type 2 diabetes.…”

Section: Discussionsupporting

confidence: 85%

“…We have previously reported that levels of serum SeP and hepatic gene expression of SEPP1 are elevated in type 2 diabetes [15]. More recently, Yang et al have reported that serum levels of SeP are increased in people with impaired glucose tolerance [16]. SeP impairs insulin signal transduction and induced dysregulation of glucose metabolism in skeletal muscle and liver, indicating that SeP functions as a type 2 diabetes-associated hepatokine that causes insulin resistance and hyperglycemia [15].…”

Section: Introductionmentioning

confidence: 99%

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Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

et al. 2014

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

et al. 2014

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“…In a recent study, serum SELP concentrations were higher in patients with type-2 diabetes or prediabetes than those with normal glucose tolerance (275). Moreover, SELP levels correlated with serum C-reactive protein (CRP) levels and carotid intima-media thickness, which are an indicator of inflammation and atherosclerosis, respectively.…”

Section: J Se Supplementation and Inflammation Associated With Diabetesmentioning

confidence: 97%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

655

482

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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“…In patients with type 2 diabetes and NAFLD showed Sep serum levels higher than controls [22]. In another study the circulating level of SeP was associated independently with thickness of carotid intimamedia [23].…”

Section: Introductionmentioning

confidence: 90%

The Role of Hepatokines in Cardiovascular Disease

Roever¹,

Es²,

Borges³

2016

J Metabolic Synd

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Non-alcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, and associated with the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (DM2). A group of liver-derived proteins called hepatokines directly affect the pathogenesis of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells. In this review we summarize the role of the representative hepatokines in the progression of CVD.

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Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

Abstract: Circulating SeP concentrations were elevated in patients with glucose metabolism dysregulation and were related to various cardiometabolic parameters including insulin resistance, inflammation, and atherosclerosis.

Cited by 166 publications

References 18 publications

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Role of Hepatokines in Cardiovascular Disease

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