Serum selenium levels and oxidative balance as differential markers in hepatic damage caused by alcohol

Rua, Rui Manuel; Ojeda, María Luisa; Nogales, Fátima; Rubio, José María León; Romero‐Gómez, Manuel; Funuyet, Jorge; Murillo, María Luisa Ojeda; Carreras, Olimpia

doi:10.1016/j.lfs.2013.10.008

Cited by 42 publications

(31 citation statements)

References 37 publications

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“…Currently, this element is considered to be an anticancer agent that prevents the processes of cell proliferation and tumor growth [4]. According to some authors, the serum selenium level is strongly associated with the severity of liver damage [5,6]. However, it should be emphasized that both the excess and deficiency of selenium exert adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Prystupa

Kiciński

Luchowska-Kocot

et al. 2017

IJERPH

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According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines—interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

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Section: Introductionmentioning

confidence: 99%

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Prystupa

Kiciński

Luchowska-Kocot

et al. 2017

IJERPH

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“…Thus, protein oxidation has to be considered one of several ethanol-related modifications that alter the functionality of proteins within the hepatocyte and especially within the mitochondrion, because ethanol increases ROS within this organelle. Protein modification elicited by the direct oxidative attack on the amino acid side chains by lipid peroxidation products, or as a consequence of reducing sugar, can lead to the generation of carbonyl groups within proteins [8]. On the other hand, reduced glutathione (GSH) is currently one of the most studied antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients

Galicia-Moreno

Rosique-Oramas

Medina-Ávila

et al. 2016

Oxidative Medicine and Cellular Longevity

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Alcohol is the most socially accepted addictive substance worldwide, and its metabolism is related with oxidative stress generation. The aim of this work was to evaluate the role of oxidative stress in alcoholic liver cirrhosis (ALC). This study included 187 patients divided into two groups: ALC, classified according to Child-Pugh score, and a control group. We determined the levels of reduced and oxidized glutathione (GSH and GSSG) and the GSH/GSSG ratio by an enzymatic method in blood. Also, protein carbonyl and malondialdehyde (MDA) content were estimated in serum. MDA levels increased in proportion to the severity of damage, whereas the GSH and GSSG levels decreased and increased, respectively, at different stages of cirrhosis. There were no differences in the GSH/GSSG ratio and carbonylated protein content between groups. We also evaluated whether the active consumption of or abstinence from alcoholic beverages affected the behavior of these oxidative markers and only found differences in the MDA, GSH, and GSSG determination and the GSH/GSSG ratio. Our results suggest that alcoholic cirrhotic subjects have an increase in oxidative stress in the early stages of disease severity and that abstinence from alcohol consumption favors the major antioxidant endogen: GSH in patients with advanced disease severity.

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“…Selenium is gaining interest because of the recognition of selenocysteine and selenoproteins as potential antioxidants in various tissues including skeletal muscle. Whether these mineral deficiencies, including zinc and selenium contribute to impaired ammonia disposal and protein synthesis are not known 13,48,49 .…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Alcoholic Liver Disease

Dasarathy

2016

Clinics in Liver Disease

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Serum selenium levels and oxidative balance as differential markers in hepatic damage caused by alcohol

Cited by 42 publications

References 37 publications

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Behavior of Oxidative Stress Markers in Alcoholic Liver Cirrhosis Patients

Nutrition and Alcoholic Liver Disease

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