Serum SCUBE-1 Levels and Return of Spontaneous Circulation Following Cardiopulmonary Resuscitation in Adult Patients

Self Cite

The current approach in cardiopulmonary resuscitation (CPR) involves interrupting the chest compressions to assess the pulse and diagnose Return of Spontaneous Circulation (ROSC). This critical step is essential for determining the effectiveness of resuscitation efforts. However, the interruption of CPR poses a challenge, prompting researchers to explore alternative methods for diagnosing ROSC without compromising the ongoing resuscitation process. One potential solution proposed in the literature is the use of the Bispectral Index (BIS). BIS is a numerical value derived from processed electroencephalogram data, providing a measure of the depth of anesthesia or sedation. Some studies have reported an increase in BIS values following successful ROSC during CPR. This observation suggests that monitoring BIS levels could offer real-time information about cerebral perfusion and neurological status, eliminating the need for pulse checks that require CPR interruption. Despite these promising indications, it is crucial to acknowledge the limited existing literature on the subject. The evidence supporting the use of BIS in diagnosing ROSC during CPR is not yet robust, and further research is warranted. Researchers are encouraged to delve into this unexplored area, conducting comprehensive studies to assess the reliability and effectiveness of BIS as a tool for continuous monitoring during resuscitation efforts. In conclusion, while the concept of using BIS to diagnose ROSC during CPR holds potential, it remains an area that requires substantial research attention. The limited existing literature underscores the need for more extensive investigations to determine the feasibility and reliability of integrating BIS into the CPR protocol. As technology advances, exploring innovative approaches for continuous assessment during resuscitation becomes imperative for improving outcomes in cardiac arrest scenarios

Section: Cardiopulmonary Resuscitationmentioning

confidence: 99%

“…Early initiation of CPR, prompt defibrillation, and coordinated advanced life support measures substantially increase the likelihood of ROSC. However, even with successful ROSC, the underlying cause of the cardiac arrest must be identified and addressed to prevent a recurrence (4,5).…”

Section: Cardiopulmonary Resuscitationmentioning

confidence: 99%

Exploring the Role of Bispectral Index in Interrupting CPR for ROSC Diagnosis: A Call for Further Research

ÖZDEMİR

2023

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“…In this way, it has been reported that adromedullin may be a shortterm mortality predictor in sepsis based on hazard ratio of 2.6 (17). SCUBE-1 is a peptide synthesized from platelets and associated with thrombosis, hypoxia and inflammation (18,19). Increased SCUBE-1 concentrations in the systemic circulation are associated with mortality in sepsis based on AUC of 0.813 with a specificity of 75.6%, a sensitivity of 81.3%, and a cutoff value of ≥4,73 (20).…”

mentioning

confidence: 99%

Prognostic Biomarkers in Sepsis

ÖZDEMİR

2023

Self Cite

We read with great interest the article titled “Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, CRP, NLR, PLR) in Patients with Sepsis” prepared by Gedik and Çiftçioğlu and published in the second issue of your journal in 2023. We would like to thank the authors and the editorial board for this descriptive study sharing data from a tertiary hospital in Kahramanmaraş province. However, we would like to touch upon a few points that may contribute to the discussion of the study.

“…SCUBE-1 accumulation was detected immunohistochemically in the subendothelial matrix of advanced atherosclerotic lesions in humans. SCUBE-1 is thought to be a new platelet adhesion molecule (5). Recent studies have revealed that SCUBE-1 expression is increased in patients with acute coronary syndrome and acute large vessel atherothrombotic stroke.…”

mentioning

confidence: 99%

The New Biomarkers for Acute Coronary Syndrome

ÖZKAN,

ÖZDEMİR

2023

We read your article prepared by Doğan and Taşlıdere, titled “Investigation of Panic Attack Patients Presenting to the Emergency Department of Bezmialem Vakıf University with Chest Pain” and published in the first issue of your magazine in 2023, with great interest. We would like to thank the authors and editorial board for this article, guides the effective use of resources in health. We would like to thank again to the authors for their efforts to clarify this situation, that is a clinical dilemma in the emergency department and that clinicians find difficult to manage We congratulate them. However, we would like to point out a few points that will contribute to the discussion of the study.