Serum sclerostin decreases following 12months of resistance- or jump-training in men with low bone mass

Abstract

Purpose We previously reported that 12 mo of resistance training (RT, 2×/wk, N= 19) or jump training (JUMP, 3×/wk, N= 19) increased whole body and lumbar spine BMD and increased serum bone formation markers relative to resorption in physically active (≥4 hr/wk) men (mean age: 44 ± 2 y; median: 44 y) with osteopenia of the hip or spine. The purpose of this secondary analysis was to examine the effects of the RT or JUMP intervention on potential endocrine mediators of the exercise effects on bone, specifically IGF-I, PTH and sclerostin. Methods Fasting blood samples were collected after a 24-h period of no exercise at baseline and after 12 months of RT or JUMP. IGF-I, PTH and sclerostin were measured in serum by ELISA. The effects of RT or JUMP on IGF-I, PTH and sclerostin were evaluated using 2×2 repeated measures ANOVA (time, group). This study was conducted in accordance with the Declaration of Helsinki and was approved by the University of Missouri IRB. Results Sclerostin concentrations in serum significantly decreased and IGF-I significantly increased after 12 mo of RT or JUMP; while PTH remained unchanged. Conclusion The beneficial effects of long-term, progressive-intensity RT or JUMP on BMD in moderately active men with low bone mass are associated with decreased sclerostin and increased IGF-I.

Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults

“…In study of Ardawi et al, premenopausal women performing physical activity for more than 120 min per week showed significantly lower serum sclerostin levels than sedentary controls [32]. Similar finding were described by Hinton et al, in which sclerostin concentrations in serum decreased by 7% in 12 months of resistance training twice a week or 12 months of completion of a jump protocol three times a week [33]. Janik et al came up to comparable results in their study, in which sclerostin concentrations were lower by 12,04% in women at the age of 50-75 year after the 12 weeks of 40 minutes bike ergometer physical training 3 times per week [17].…”

Bone adaptation in response to treadmill exercise in young and adult mice

“…In contrast, adult mice demonstrated a lack of SOST/scelrostin suppression in response to exercise at the gene and protein level. Even though men and women who are more active tend to display lower circulating levels of sclerostin ( Amrein et al, 2012 ), the efficacy of exercise to suppress sclerostin has varied between studies ( Bergstrom et al, 2012 ; Armamento-Villareal et al, 2012 ; Hinton et al, 2017 ; Grasso et al, 2015 ; Kerschan-Schindl et al, 2015 ). Similarly to our findings, long-term studies found no significant changes in sclerostin levels after 1 year of intervention ( Bergstrom et al, 2012 ; Armamento-Villareal et al, 2012 ).…”

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“…In humans, study results differ a little bit. An exercise program lasting 12 months (resistance or jump training) led to decreases in serum sclerostin levels [22], but except for our investigation on ultradistance runners [23], no other trial detected a decrease of sclerostin following an acute exercise bout. The increase of inflammatory cytokines has been shown to be associated with the transient increase of serum sclerostin following a single workout [24].…”