Serum, Saliva, and Gingival Crevicular Fluid Osteocalcin: Their Relation to Periodontal Status and Bone Mineral Density in Postmenopausal Women

Abstract

The results further support the concept that osteocalcin levels in GCF correlates with periodontal but not with osteoporosis status.

Correlation of Serum Osteocalcin Level and Periodontal Attachment Loss With Osteoporosis Risk Status in Postmenopausal Women

“…Table 3 summarizes that there was no statistically significant association between the serum osteocalcin levels and the severity of CAL (p=0.31). This finding is similar to that of a study conducted by Bullon et al [21] showing that there was no difference in CAL with regard to serum osteocalcin levels but suggesting that CAL was correlated with gingival crevicular fluid (GCF) and saliva osteocalcin levels. Osteocalcin is produced by osteoblasts and secreted directly into the blood in small amounts.…”

Relationships Among Renal Function, Bone Turnover and Periodontal Disease

“…The serum level of this protein is considered to be a marker of bone formation. Serum osteocalcin is presently considered a valid marker of bone turnover when resorption and formation are coupled and a specific marker of bone formation when formation and resorption are uncoupled (Bullon et al, 2005). Osteocalcin has also been found in the gingival crevicular fluid (GCF).…”

“…Several studies found an increased level of serum osteocalcin in subjects with CRF. Moreover, the level of GCF osteocalcin was found to be significantly associated with periodontal disease, since there was an association with pocket depth, clinical attachment level and bleeding on probing (Bullon et al, 2005). Therefore, it might be reasonable to explain an effect of CRF on periodontal disease by its effect on bone metabolism (especially alveolar bone) which is specifically marked by the level of serum osteocalcin and/or GCF osteocalcin.…”

The Effects of Menopause on Periodontal Tissue

“…Bullon et al reported that low serum osteocalcin concentration is associated with a significantly higher percentage of decrease in probing depth and clinical attachment level after periodontal treatment in postmenopausal women. Low saliva osteocalcin concentrations are significantly associated with a higher percentage of decrease in probing depth (69). Lorne et al reported the therapeutic potential of long-term subantimicrobial-dose doxycyline therapy to reduce periodontal collagen breakdown and alveolar bone resorption in postmenopausal women (70).…”