Serum S100 calcium binding protein A4 (S100A4, metatasin) as a diagnostic and prognostic biomarker in epithelial ovarian cancer

Lv, Yingda; Niu, Zhaojian; Guo, Xiangyu; Yuan, Feng; Liu, Y

doi:10.1080/09674845.2017.1394052

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…Epithelial–mesenchymal transition (EMT) represents a cell biological program and regulates cell invasion and metastasis in cancers, and miRNAs regulates EMT-associated signaling genes [ 40 ]. As a metastasis-associated protein and marker of the EMT, S100A4 contributes to the progression of several types of cancer [ 41 ]. Giving its important role in metastasis, S100A4 may be a potential target for cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of microRNA-125b and its contribution to ovarian carcinogenesis

Guan

Wang

et al. 2020

Bioengineered

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The underlying mechanisms of recurrence and metastasis of epithelial ovarian cancer (EOC) are largely unknown. In the present study, we investigated the clinical significance of microRNA-125b (miR-125b) and its role in ovarian tumorigenesis and progression. Seventy patients of EOC and paired tissues were enrolled from 2015 to 2017. qRT-PCR was used to evaluate miR-125b expression in tumor tissues and EOC cell line. Gain-and-loss function of miR-125b was achieved to explore the changes in cell biological function. We found that miR-125b expression in EOC tissues, especially in the high-grade tissues (P < 0.001), was significantly lower compared to the matched adjacent noncancerous tissues and associated with pathological type, stage, and overall survival (P < 0.05). Upregulation of miR-125b promoted apoptosis and decreased cell survival rate and migration, and vice versa in vitro. Mechanistically, miR-125b negatively regulated S100A4, a metastasis-associated protein. MiR-125b overexpression significantly decreased tumor growth and inhibited lung metastasis in vivo. Our results supported that miR-125b contributes to the progression of EOC by targeting S100A4. It potentially acts as a potential biomarker and therapeutic target of EOC.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of microRNA-125b and its contribution to ovarian carcinogenesis

Guan

Wang

et al. 2020

Bioengineered

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“…Abnormal expression of S100 proteins has been implicated in cancer [20, 21], autoimmune diseases [22], and chronic inflammatory disorders [23]. In particular, increased expression of S100A1 [24], S100A4 [25], S100A7 [26], and S100A14 [17] has been documented in multiple cancers including ovarian cancer. S100A1, A3, A6, A11, A13, A14, A16 and S100Z have been reported to be downregulated in oral squamous cell carcinoma (OSCC) patients compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

S100A10 silencing suppresses proliferation, migration and invasion of ovarian cancer cells and enhances sensitivity to carboplatin

Wang

Yan

et al. 2019

J Ovarian Res

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BackgroundOvarian cancer is the leading cause of gynecological cancer-related mortality. The novel oncogene S100A10 has been reported to be involved in cancer cell proliferation, invasion and metastasis. The role of S100A10 in ovarian cancer has not been well studied and the effect of S100A10 on chemotherapy remains unclear. The aims of the present study were to investigate the functional role of S100A10 in the progression and carboplatin sensitivity of ovarian cancer.MethodsWe examined the expression levels in tissues of S100A10 in 138 cases of ovarian cancer by IHC. To determine the functional roles of downregulated S100A10 in ovarian cancer, cell proliferation, colony formation, cell migration and invasion assays were performed. Chemoresistance was analyzed by apoptosis assay. A xenograft tumor model was established to confirm the role of S100A10 in carboplatin resistance in vivo. Using Western blot assays, we also explored the possible mechanisms of S100A10 in ovarian cancer.ResultsThe results showed that increased expression of S100A10 was positively associated with carboplatin resistance (P < 0.001), tumor grade (P = 0.048) and a poorer prognosis (P = 0.0053). Functional analyses demonstrated that S100A10 suppression significantly suppressed ovarian cancer cell proliferation, colony formation, cell migration and invasion, remarkably increased carboplatin-induced apoptosis in SKOV3 and A2780 cells and inhibited tumor growth in vivo. Downregulation of S100A10 expression could inhibit cell proliferation and enhance ovarian cancer cell sensitivity to carboplatin, possibly involving the regulation of cleaved-Caspase3 and cleaved-PARP.ConclusionsTogether, the results of the present study reveal that S100A10 expression can be used as a predictive marker for the prognosis of ovarian cancer and chemosensitivity to carboplatin.

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“…The equilibrium dissociation constants, Kd, estimated for S100A4 protein, 0.5 μM and 2.4 μM, resemble those reported for GM-CSF interaction with S100A6 [26] and S100P [27] (Table 1), and the Kd values for S100A4 complex with GST-RAGE fusion protein (0.6 μM and 1.7 μM [62]). Furthermore, the lowest Kd value for the S100A4 -GM-CSF complex is close to the level of serum S100A4 observed in some pathological conditions (0.1 μM [63]), indicating the potential physiological significance of this complex. In addition, local concentrations of extracellular S100A4 upon injury to S100A4-positive cells may be even higher, favoring formation of S100A4 -GM-CSF complex.…”

Section: Gm-csf Binding To S100 Proteinsmentioning

confidence: 63%

Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins

Kazakov,

Rastrygina,

Vologzhannikova

et al. 2024

Cell Calcium

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Serum S100 calcium binding protein A4 (S100A4, metatasin) as a diagnostic and prognostic biomarker in epithelial ovarian cancer

Cited by 13 publications

References 12 publications

Clinical significance of microRNA-125b and its contribution to ovarian carcinogenesis

Clinical significance of microRNA-125b and its contribution to ovarian carcinogenesis

S100A10 silencing suppresses proliferation, migration and invasion of ovarian cancer cells and enhances sensitivity to carboplatin

Recognition of granulocyte-macrophage colony-stimulating factor by specific S100 proteins

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