Serum S-100 β Protein During Coronary Artery Bypass Graft Surgery With or Without Cardiopulmonary Bypass

Wang, Kuan-Jen; Wu, Hsiang-Hua; Fang, Shih-Yuan; Yang, Yu-Ren; Tseng, Audrey

doi:10.1016/j.athoracsur.2005.04.011

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…[4] In our study, a similar pattern was observed in all the groups where the level of S100 β was maximum just after CPB and which gradually declined over next 24 h [ Table 3]. Wang et al [18] compared patients undergoing off-pump CABG and on-pump CABG and found that serum S-100 β protein was lowest immediately before induction of anesthesia and significantly increased before and after CPB, then declined by the first postoperative day in both groups. On the day after surgery, S-100 β protein levels were similar between groups, but were higher than the baseline within each group.…”

Section: Discussionsupporting

confidence: 88%

Comparison of S100β levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques

et al. 2011

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Cardiac surgery with aid of cardiopulmonary bypass (CPB) is associated with neurological dysfunction. The presence of cerebrospecific protein S100β in serum is an indicator of cerebral damage. This study was designed to evaluate the influence of three different anesthesia techniques, on S100β levels, in patients undergoing coronary artery bypass grafting on CPB. A total of 180 patients were divided into three groups - each of who received sevoflurane, isoflurane and total intravenous anesthesia as part of the anesthetic technique, respectively. S100 were evaluated from venous sample at following time intervals - prior to induction of anesthesia (T1), after coming off CPB (T2); 12 h after aortic cross clamping (T3) and 24 h after aortic cross clamping (T4). In all three groups, maximal rise in S100β levels occurred after CPB which gradually declined over next 24 h, the levels at 24 h post-AOXC being significantly higher than baseline levels. Significantly low levels of S100β were noted at all postdose hours in the sevoflurane group, as compared to the total intravenous anesthesia (TIVA) group, and at 12 and 24 h postaortic cross clamp, in comparison to the isoflurane group. Comparing the isoflurane group with the TIVA group, the S100 levels were lower in the isoflurane group only at 24 h postaortic cross clamp. It was concluded that maximum rise in S100β levels occurs immediately after CPB with a gradual decline in next 24 h. The rise in S100β levels is significantly less in patients administered sevoflurane in comparison to isoflurane or TIVA. Hemodynamic parameters had no influence on the S100β levels during the first 24 h after surgery.

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Section: Discussionsupporting

confidence: 88%

Comparison of S100β levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques

et al. 2011

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“…Postoperative increases in serum S100β concentrations are related to neurocognitive dysfunction [24], severity of brain damage, early and late outcomes as well as length of hospital stay [17]. In the present study, the mean serum S100β concentration increased 1-6 h after CO 2 pneumoperitoneum and had not returned to baseline 1 day after pneumoperitoneum.…”

Section: Discussionmentioning

confidence: 55%

Effects of CO<sub>2</sub> Pneumoperitoneum on the Cognitive Function of Patients Undergoing Gynecologic Laparoscopy

Liu

Bao²,

Lu³

2015

Gynecol Obstet Invest

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Aim: To evaluate the effects of CO₂ pneumoperitoneum during gynecologic laparoscopy on patients' postoperative cognitive function. Methods: This prospective clinical study included 225 adult female patients with American Society of Anesthesiologists physical status I or II. Patients underwent conventional open surgery (group I, n = 115) or gynecologic laparoscopy using abdominal insufflation with CO₂ to an intra-abdominal pressure of 15 mm Hg (group II, n = 110). Serum S100β and neuron-specific enolase (NSE) concentrations were measured, both immediately before surgery and before the patient awoke after surgery. The Mini-Mental State Examination (MMSE) was administered 1 day before surgery as well as 1, 6, 12, 24 and 72 h after surgery and before discharge. Results: MMSE scores were significantly lower relative to baseline at 1, 6 and 12 h post surgery, but returned to baseline by 48 h (group I) or 72 h (group II) post surgery. One hour after surgery, S100β serum levels were higher in group II than in group I (p < 0.05). NSE levels did not differ between the groups. In group II, the MMSE score significantly correlated with serum S100β or NSE concentrations. Conclusion: CO₂ pneumoperitoneum influences postoperative cognitive function in patients undergoing gynecologic laparoscopy.

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“…Parmi ces biomarqueurs la protéine S-100b, protéine d'origine astrocytaire, qui traverse la barrière hémato-encéphalique, a fait l'objet d'une attention particulière. Son manque de spécificité (cette protéine, étant produite par les cellules graisseuses médiastinales, a une concentration élevée dans les aspirations de cardiotomie) rend difficile l'interprétation des études selon que la procédure a comporté ou non un traitement des aspirations du site opératoire [19,20]. L'énolase neurone-spécifique [neuron specific enolase (NSE)] est une des cinq isoformes de l'enzyme glycolytique énolase et constitue un marqueur de lésions cérébrales [18].…”

Section: Biomarqueurs Systémiques De Lésions Cérébralesunclassified

Modifications des fonctions cognitives après chirurgie cardiaque

2009

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Serum S-100 β Protein During Coronary Artery Bypass Graft Surgery With or Without Cardiopulmonary Bypass

Cited by 12 publications

References 25 publications

Comparison of S100β levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques

Comparison of S100β levels, and their correlation with hemodynamic indices in patients undergoing coronary artery bypass grafting with three different anesthetic techniques

Effects of CO<sub>2</sub> Pneumoperitoneum on the Cognitive Function of Patients Undergoing Gynecologic Laparoscopy

Modifications des fonctions cognitives après chirurgie cardiaque

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