Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Retinol-Binding Protein 4 Is an Independent Factor Associated With Triglycerides and a Determinant of Very Low-Density Lipoprotein–Apolipoprotein B100 Catabolism in Type 2 Diabetes Mellitus

“…16 In a study performed in 75 healthy subjects, plasma rbp4 levels have been shown to be correlated with liver fat content, 17 and it has been reported that plasma levels of rbp4 were higher in T2DM patients with nonalcoholic fatty liver disease than in T2DM patients without nonalcoholic fatty liver disease. 18 Thus, we cannot exclude that the positive association reported between rbp4 and plasma triglycerides, in patients with T2DM, could not be as a result of the increased liver fat content observed in this population. Indeed, liver fat content has been shown to be tightly associated with plasma triglycerides in patients with T2DM, 19,20 and, so far, the association between plasma rbp4 and triglycerides independent of liver fat content has never been studied.…”

“…First of all, it is not clear whether this association is direct or indirect via liver fat content. Indeed, in some animal 16 and human 17,18 studies, increased plasma rbp4 levels have been shown to be associated with nonalcoholic fatty liver disease. For instance, reduction in plasma levels of rbp4, using RNA oligonucleotide against rbp4 in high-fat diet-fed mice has been shown to reduce both plasma triglycerides and liver fat content, suggesting that the decrease in plasma triglycerides might be a result of the reduction in hepatic triglycerides.…”

Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue

“…by guest, on May 10, 2018 www.jlr.org Downloaded from effects on hepatic endocannabinoid signaling ( 62 ), and human observational studies ( 63,64 ). However, the specifi c mechanisms underlying these observations are not well-established.…”

Serum retinol binding protein 4 is not decreased in congenital generalized lipodystrophy: a case series

“…Some studies have already indicated that the liver may be the most important regulator of RBP-4 levels (13,14). Recently, Stefan and cols.…”

“…Patients with NAFLD presented significant higher levels of serum RBP-4 in comparison with patients that did not fit ultrasound criteria for NAFLD (13). Finally, Yagmur and cols.…”