Serum Resistin Level in Obese Male Children

Abstract

Objectives. Resistin is a member of cysteine-rich molecules. Several studies have been carried out to determine the biological effect of resistin, nevertheless a significant number are animal studies. All the studies performed regarding the relationship between serum resistin and obesity were merely accomplished in women. To the best of our knowledge, there is no survey on the correlation of the serum resistin level and obesity in male children. The aim of the present study is to assess serum concentration of resistin in obese male children. Methods. Between June 2009 and January 2010, we enrolled 42 randomly selected obese male students (body mass index (BMI) >95th percentile, age 15.7 ± 1.5). Thirty-eight healthy age-matched male students with normal BMI (<85th percentile) were selected as a control group for the purpose of comparison of the serum resistin levels. Results. Serum resistin levels were measured in obese and control group. No significant difference was found between resistin levels of the 2 groups (obese: 9.21 ± 5.6 ng/mL versus normal: 9.83 ± 4.3 ng/mL; P = .582). There was no significant correlation between serum resistin level and BMI. Assessing the resistin level in male subjects was the distinct feature of our study. The outstanding finding of this research is that there is no correlation between serum resistin level and obesity. Conclusion. We have demonstrated that there is no correlation between obesity in male children and resistin level. Consequently, metabolic abnormalities of insulin resistance seen in obese male patients are not related to resistin.

Resistin Levels In Healthy Non-Diabetes Nigerian-Africans: Effect Of Obesity The ABU Adiporesistin Survey

“…1 Later studies however, documented contrary findings attributing the lower levels of resistin in obese rodents to its suppression by free fatty acids. 28 The present study showed that in Nigerian-Africans, plasma resistin levels rose with increasing BMI categories with highest levels in subjects with severe obesity, however, with no significant positive correlation with age, insulin resistance, fasting insulin, fasting blood glucose, body mass index and central obesity. This is consistent with some previous study, which showed significantly higher resistin concentrations in overweight and obese subjects but without correlation with insulin resistance, blood glucose, lipids, insulin and changes in body mass index & visceral fat except for positive correlations with age.…”

Concentrations of leptin, adiponectin, and resistin in the serum of obese cats during weight loss

“…However, in humans, resistin is predominantly produced by non-adipocytes such as monocytes/macrophages [27], and increased blood level in resistin is caused by secretion from macrophage-invaded adipocytes [12, 24]. Recent evidence in humans suggests that the serum resistin concentration does not reflect the degree of obesity [1, 7, 14, 21]. According to our unpublished data, feline resistin mRNA is expressed not only in adipose tissue, but also within the lung and spleen.…”

Association of resistin level with acanthosis nigricans in obese adolescents

“…This was similar to the results of a study conducted in Iran. 21 Elevated levels of resistin in this study have been obtained in acanthosis nigricans scale 2. The study of Lestari R (2010) obtained a mean HOMA-IR was higher in subjects with higher debree of acanthosis nigricans, especially in the group of acanthosis nigricans scale 3 and 4.…”