Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population

Al-Daghri, Nasser M.; Chetty, R.; McTernan, P. G.; Al-Rubean, Khalid; Al‐Attas, Omar S.; Jones, Alan; Kumar, Sudhesh

doi:10.1186/1475-2840-4-10

Cited by 65 publications

(8 citation statements)

References 35 publications

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“…Some studies reported that serum resistin was significantly associated with CRP in patients. 32 – 33 In this study, resistin was significantly correlated with CRP in both sexes. A previous study showed that CRP level was significantly higher in the BSS group with high serum amyloid P component (SAP) level.…”

Section: Discussionsupporting

confidence: 52%

Association of serum resistin with blood stasis syndrome in traditional Korean medicine for metabolic diseases: A cross-sectional multicenter observational study

Ho²,

Jung³

2021

Integrative Medicine Research

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Background Blood stasis syndrome (BSS) is considered as the cause of several chronic disease including metabolic diseases in traditional East Asian medicine. In this study, we investigated the levels of serum resistin and other proteins related to metabolic syndrome (MS) and several other diseases categories to identify the association with BSS. Methods This was a cross-sectional, multicenter study of patients recruited from seven traditional Korean Medicine (TKM) hospitals. To identify whether there was an association with BSS in specific disease conditions, including MS, serum protein levels were evaluated using the multiplex method. Results A total of 885 patients (419 patients with BSS, 376 patients without BSS, and 90 healthy controls) participated in the study, and 139 patients had MS. The resistin and insulin levels were significantly higher in patients with BSS than in patients without BSS and normal subjects ( P = 0.002 and P = 0.046, respectively). Patients with BSS who had MS exhibited significantly higher resistin levels than those in patients without BSS and normal subjects ( P = 0.049). In addition, the levels of serum resistin were significantly correlated with symptoms of the BSS, especially dark red gums, dark facial complexion, and nocturnal pain. Conclusions Despite several limitations, these results demonstrated that resistin levels are potentially associated with the pathogenesis of BSS in MS. Trial registration number Clinical Research Information Service (CRIS): KCT0000916.

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Section: Discussionsupporting

confidence: 52%

Association of serum resistin with blood stasis syndrome in traditional Korean medicine for metabolic diseases: A cross-sectional multicenter observational study

Ho²,

Jung³

2021

Integrative Medicine Research

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“…In this work, the hs-CRP levels were higher in rats receiving the oxysterol diet than in rats receiving the cholesterol or standard diets. If we focus on the hs-CRP results in connection with resistin levels, also increased in rats receiving oxysterols, we can hypothesize that resistin may also play a role as a good marker of cardiovascular risk, as it has been previously demonstrated in populations with type 2 diabetes and coronary heart disease [36].…”

Section: Discussionmentioning

confidence: 88%

Alteration of Some Inflammatory Biomarkers by Dietary Oxysterols in Rats

et al. 2012

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Oxysterols are structurally similar to cholesterol, but are characterized by one or more additional oxygen-containing functional groups. These compounds are implicated in inflammation given their ability to cause irreversible damage to vascular cells. The aim of this study was to study the alteration of some inflammatory biomarkers in Wistar rats in response to dietary oxysterols. Eighteen rats were randomly divided into three groups of six rats each. A standard diet supplemented with 1% (w/w) pure cholesterol (Chol group) or 1% (w/w) of an oxidized cholesterol mixture (COPs group) was fed for 8 weeks. Blood serum was separated; abdominal, pericardial, and epididymal adipose tissue was removed carefully. The COPs subjects exhibited significant increase in blood pressure and serum triacylgycerols as well as increased body fat index and pericardic, abdominal, and epididymal adipose tissue. These effects were accompanied by elevated circulating levels of plasma high-sensitivity C-reactive protein, tumor necrosis factor alpha, and resistin. We suggest that dietary oxysterols have an important pro-inflammatory effect.

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“… 43 Furthermore, Aldaghri et al (2005) showed that serum resistin is related to both LDL and CRP, providing a possible link between insulin resistance, hyperlipidemia and inflammation. 44 …”

Section: Specific Diabetes Syndromesmentioning

confidence: 99%

Epidemiology, Clinical and Complications Profile of Diabetes in Saudi Arabia: A Review

Elhadd

Al-Amoudi

Alzahrani

2007

Annals of Saudi Medicine

104

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Diabetes mellitus is emerging as a major public health probelm in Saudi Arabia in parallel with the worldwide diabetes pandemic, which is having a particular impact upon the Middle East and the third world. This pandemic has accompanied the adoption of a modern lifestyle and the abandonment of a traditional lifestyle, with a resultant increase in rates of obesity and other chronic non-communicable diseases. The indigenous Saudi population seems to have a special genetic predisposition to develop type 2 diabetes, which is further amplified by a rise in obesity rates, a high rate of consanguinity and the presence of other variables of the insulin resistance syndrome. We highlight the epidemiology, clinical and complications profiles of diabetes in Saudi people. Diabetes is well studied in Saudi Arabia; however, there seems to be little research in the area of education and health care delivery. This is of paramount importance to offset the perceived impact on health care delivery services, to lessen chronic diabetes complications, and to reduce the expected morbidity and mortality from diabetes.

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Serum resistin is associated with C-reactive protein and LDL- cholesterol in type 2 diabetes and coronary artery disease in a Saudi population

Cited by 65 publications

References 35 publications

Association of serum resistin with blood stasis syndrome in traditional Korean medicine for metabolic diseases: A cross-sectional multicenter observational study

Association of serum resistin with blood stasis syndrome in traditional Korean medicine for metabolic diseases: A cross-sectional multicenter observational study

Alteration of Some Inflammatory Biomarkers by Dietary Oxysterols in Rats

Epidemiology, Clinical and Complications Profile of Diabetes in Saudi Arabia: A Review

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