Serum pyruvate kinase in carriers of duchenne muscular dystrophy

The female carrier of Duchenne muscular dystrophy.

“…Some, such as that based on raised serum activity of pyruvate kinase, are at least potentially practicable,"7-'9 though having little or no advantage over creatine kinase. [20][21][22] Others, such as the tests based on abnormal polyribosomal protein synthesis of muscle in vitro,23 changes in phosphorylation of erythrocyte membrane spectrin 11,24 increased lactate dehydrogenase isoenzyme 5,25 and reduction in lymphocyte capping,26 are much more complex and still need validation. Electrocardiographic abnormalities,8 27 changes on quantitative electromyography,28-30 and pathological changes in the muscle under light3' 32 or electron microscopy3334 have also been used as supplementary tests for detecting carriers; and some authors have favoured combined tests.…”

Pyruvate‐kinase (PK) and creatine‐kinase (CK) in normal pregnancy and its implication in genetic counseling of duchenne muscular dystrophy (DMD)

“…Several investigations [Harano et al, 1973;Alberts and Samaha, 1974;Smith and Thomson, 1977;Yamuna et al, 1977;Weinstock et al, 1977;Zatz et al, 19781 have shown that serum pyruvate-kinase (PK) is grossly elevated in patients with DMD. However, we are unaware of a report on the determination of serum PK in male fetuses at risk for DMD.…”