Serum PSA and cure perspective for prostate cancer in males with nonpalpable tumor

Dall’Oglio, Marcos F.; Crippa, Alexandre; Passerotti, Carlo C.; Nesrallah, Luciano J.; Leite, Kátia Ramos Moreira; Srougi, Miguel

doi:10.1590/s1677-55382005000500004

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…CaP screening programs have shown that using 4.0 ng/mL as a cutoff results in only clinically significant tumors being detected, and one third of the men treated for radical prostatectomy disease that had progressed beyond the prostate (8). Lowering PSA levels to 2.5 ng/mL seems to better detect organ-confined tumors, enhancing chances of disease-free and overall survival, particularly in younger men (19,20). In association with lowering PSA levels, the current practice of more intensive biopsy regimens could lead to the detection of non-significant tumors.…”

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Histopathological findings in extended prostate biopsy with PSA ≤ 4 ng/mL

et al. 2008

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Objective: Cancer detection has been reported in up to 27% of patients when lowering the PSA cutoff to 2.5 ng/mL. Although this practice could increase the number of biopsies performed, it also could lead to more frequent detection of significant prostate cancers at an organ-confined stage and/or a less aggressive state. This study describes the incidence of malignancy and tumor characteristics in extended prostate biopsies with PSA ≤ 4 ng/mL. Materials and Methods: Prostate biopsies from 1081 patients where examined, 275 (25.4%) patients had PSA level ≤ 4 ng/mL. Results: Cancer was diagnosed in 32.0% and 35.7% of patients with PSA ≤ 4 ng/mL and > 4 ng/mL, respectively (p = 0.906). The median Gleason score was 7 independent of PSA > or ≤ 4 ng/mL (p = 0.078). The median number of cores positive for tumor was 4 and 3, respectively, for PSA > 4 ng/mL and PSA ≤ 4 ng/mL (p = 0.627). There was a difference in the total percent of tumors involving all cores, 11% and 7% for PSA > or ≤ 4 ng/mL (p = 0.042). Fifty-six patients underwent radical prostatectomy, 12 had PSA ≤ 4 ng/mL. In both groups, a diagnosis of cancer was accurate with no differences in Gleason score, tumor volume or staging for both groups. Conclusion: When PSA is below 4 ng/mL, cancer is detected in a proportion equal to the proportion diagnosed with a PSA > 4 ng/mL, and tumor characteristics are similar between the two groups. Only clinically significant tumors were diagnosed following radical prostatectomy.

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confidence: 99%

Histopathological findings in extended prostate biopsy with PSA ≤ 4 ng/mL

et al. 2008

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Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

Varma¹,

Jindal²,

Sharda³

et al. 2022

ann urol oncol

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Background Prostate cancer (PCa) is the second most frequent malignancy (after lung cancer) in men worldwide .In prostate cancer, immunohistochemistry (IHC) has an important role in the diagnostic confirmation. Gleason score, tumour volume, surgical margins and Ki-67 index are the most significant prognostic factors. The value of different biomarkers like p53, Ki-67, PSMA, androgen receptor mutations, IGF, E-cadherin remains to be applied in clinical practice. In the present study we studied the expression of PSMA and Ki 67 IHC marker in prostatic carcinoma cases and its relation with Gleason score and Gleason grade group of tumour. Method A total of 52 cases of prostate carcinoma diagnosed on histopathology as adenocarcinoma in the Department of surgical pathology within 2.5 years duration were further studied immunohistochemically by PSMA and Ki 67 antibodies. Results At the time of presentation most of the cases have serum PSA level 11-50 ng/ml and with increasing Gleason score it can be ≥100ng/ml. Majority of cases have Gleason score 7 and the most common Gleason grade group is 2. PSMA and Ki 67 IHC marker is significantly correlated with Gleason score and Gleason grade group. PSMA expression is significantly correlated with perineural invasion and Ki 67 with bone metastasis. Conclusion PSMA and Ki 67 IHC marker can be used in conjunction with or as a substitute to Gleason scoring system for proper risk.

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Serum PSA and cure perspective for prostate cancer in males with nonpalpable tumor

Abstract: Non-palpable prostate cancer presents higher chances of cure when the PSA is inferior to 4 ng/mL.

Cited by 2 publications

References 19 publications

Histopathological findings in extended prostate biopsy with PSA ≤ 4 ng/mL

Histopathological findings in extended prostate biopsy with PSA ≤ 4 ng/mL

Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

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