Serum Proteomic Analysis Based on iTRAQ in Miners Exposed to Soil Containing Rare Earth Elements

Liu, Heming; Wang, Jianzhong; Yang, Zenghua; Wang, Kunzheng

doi:10.1007/s12011-015-0312-9

Cited by 15 publications

(4 citation statements)

References 37 publications

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“…The content of REEs in the hair of miners, particularly light REEs (La, Ce, Pr, and Nd), was much higher than the values in the hair of non-miners from both mining area and control area (Wei et al, 2013). Liu et al (2015) found higher REE hair levels in miners working at the Baiyun Obo mining area (China), affecting the levels of proteins in serum that participate in various biological processes. Increased La levels were also found in the lung tissue of deceased smelter workers (Gerhardsson and Nordberg, 1993).…”

Section: Gd Contrast Agents Are Causing Health Problemsmentioning

confidence: 85%

Toxicity of rare earth elements: An overview on human health impact

Brouziotis

Giarra

Libralato

et al. 2022

Front. Environ. Sci.

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Rare earth elements (REEs) are metals including the 15 lanthanides together with Yttrium and Scandium. China is the leading country in their exploitation and production (∼90%). REEs are necessary for the production of several technological devices. This extended use of REEs has raised concerns about human health safety. In this review, we investigated the hazard of REEs to human health and the main gaps into the knowledge like as the need to develop further focused research activity. We categorized the research papers collected into eight main sections: environmental exposure, association of REEs with health problems, exposure to REEs due to lifestyle, REE exposure through the food chain, Gd contrast agents causing health problems, occupational REE exposure, and cytotoxicity studies of REEs. This review provided information about the exposome of REEs (the exposure of REEs to the human body), the existing research data, and the gaps that require attention and must be further investigated. More than one third of the literature about REE toxicity to human health concerns their cytotoxicity to human cell lines, while hair, blood serum and blood are the most studied matrices. The main results evidenced that REEs can enter human body via several routes, are associated with numerous diseases, can cause ROS production, DNA damage and cell death, and are more toxic to cancer cells than normal cells.

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Section: Gd Contrast Agents Are Causing Health Problemsmentioning

confidence: 85%

Toxicity of rare earth elements: An overview on human health impact

Brouziotis

Giarra

Libralato

et al. 2022

Front. Environ. Sci.

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“…In the hair of the miners in China the result shows that the content of REE and Fe in the exposure group is significantly higher than that of the control group, but the content of Ca in the exposure group is significantly lower than that of the control group. Some differentially expressed proteins, in which 16 proteins are upregulated and 13 proteins are downregulated, may be related to neurovirulence, hepatotoxicity, pathological fibrosis, osteoporosis, and anticoagulation caused by REEs [ 26 ]. In children of two ethnic groups of Taiwan, serum Sc (2, 9 and 4.1 μg/L) was higher in girls [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Microelement composition of serum in Dolgans, indigenous inhabitants of the Russian Arctic, in the conditions of industrial development of territories

Сивцева

Sivtseva

Shadrina

et al. 2020

International Journal of Circumpolar Health

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The geochemical conditions of landscapes are the content in the environment of certain chemical elements and their compounds, the lack or excess of which causes deviations in the state of human health. This problem has arisen in connection with the extraction of alluvial diamonds and the forthcoming development of the Tomtor deposit of rare-earth metals in the territories where the indigenous peoples of the North live. The study included 107 indigenous people of the North, belonging to the ethnic group of Dolgans living in the village of Yuryung-Khaya, Anabar district, Yakutia of Russia. The method of mass spectrometry was used to study the content of 13 trace elements in blood serum (P, Sc, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Rb, Sr, Cs, Pb). The study revealed an increase in the content of the macroelement phosphorus (148 mg/L) and trace elements of chromium (277 μg/L), manganese (133 μg/L), iron (5219 μg/L), nickel (57 μg/L) in serum of Dolgans, which may affect the development of diseases of the cardiovascular system and other diseases among indigenous inhabitants of the Arctic under conditions of industrial development of territories.

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“…Excess Ce and La levels in urine [333] REE miners Excess REE level in hair and dysregulation of the protein expression [334] e-waste processing Reduced level of hemoglobin in REE-exposed [335] Table 7. Associated health disorders with selected REE.…”

Section: Manufacturing Ce and La Oxidementioning

confidence: 99%

On membrane-based approaches for rare earths separation and extraction – Recent developments

Kujawa,

Al Gharabli,

Szymczyk

et al. 2023

Coordination Chemistry Reviews

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Serum Proteomic Analysis Based on iTRAQ in Miners Exposed to Soil Containing Rare Earth Elements

Cited by 15 publications

References 37 publications

Toxicity of rare earth elements: An overview on human health impact

Toxicity of rare earth elements: An overview on human health impact

Microelement composition of serum in Dolgans, indigenous inhabitants of the Russian Arctic, in the conditions of industrial development of territories

On membrane-based approaches for rare earths separation and extraction – Recent developments

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