Serum Proteins in Cadmium Poisoned Rabbits

Axelsson, Bengt; Piscator, Magnus

doi:10.1080/00039896.1966.10664383

Cited by 27 publications

(1 citation statement)

References 27 publications

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“…8 Calcium was omitted since it was found to decrease the solubility of the fatty acid (13). Animals-Sprague-Dawley descendent male albino rats weighing 150-210 g3 were used.…”

Section: Methodsmentioning

confidence: 99%

Effect of Cadmium on Palmitic Acid Metabolism by Rat Liver Homogenate

Farid

Born

Kessler

et al. 1974

Journal of Pharmaceutical Sciences

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“…8 Calcium was omitted since it was found to decrease the solubility of the fatty acid (13). Animals-Sprague-Dawley descendent male albino rats weighing 150-210 g3 were used.…”

Section: Methodsmentioning

confidence: 99%

Effect of Cadmium on Palmitic Acid Metabolism by Rat Liver Homogenate

Farid

Born

Kessler

et al. 1974

Journal of Pharmaceutical Sciences

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Effects of subcutaneous and oral cadmium on iron metabolism: Role of ceruloplasmin and metallothionein

1984

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Male ICR mice were either given water containing Cd at a level of 192-200 ppm for 45 days (ingestion group), or were injected subcutaneously once a week with Cd (1 mg/kg) as CdCl2 for 7 weeks (injection group). The control group was given Cd-free water. In both Cd groups, the hematocrit and hemoglobin values did not change markedly. In the ingestion group, the Fe concentration decreased greatly in the liver, kidney, spleen, and duodenum. These decreases may be due to depression of Fe absorption from the intestine. In the injection group, Fe increased in the liver, spleen, and duodenum, although it decreased in the kidney. By Sephadex G-200 gel filtration, Fe-proteins in the hepatic supernatants were located in the void volume region of this gel column in both Cd groups. Apparently, Fe was not a component of metallothionein (MT) protein. The hepatic MT induction by Cd resulted in an increase in hepatic supernatant Cu. Serum Cu and ceruloplasmin (Cp) activity were stimulated only in the injection group. The enhancement of Cp activity may possibly be due to the increase in hepatic Cu which was accompanied by an increase in hepatic Fe, rather than a decrease. Our observations suggest that Fe metabolism is influenced differentially by the administration route of Cd.

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Early signs of oral and inhalative cadmium uptake in rats

Prigge¹

1978

Arch. Toxicol.

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Female wistar rats, 170--190 g, were exposed for 90 days to cadmium oxide aerosols containing 25 and 50 microgram Cd/m3 and for 63 days to 100 microgram Cd/m3. Simultaneously female wistar rats, 170--190 g, were fed 25, 50, and 100 ppm cadmium in drinking water for 90 days. After inhalation and ingestion of the metal, there were comparable kidney cadmium levels, but higher liver and blood levels after oral uptake. Coincident with the higher blood cadmium concentrations, proteinuria was observed only after oral administration. Likewise, there was a significant decrease of serum iron after ingestion and no lowering of the serum iron after inhalation of the metal. The inhalation led to a marked dose dependent weight increase of the lungs, which was followed by an impairment of gas exchange. Obviously, after inhalative cadmium uptake of 90 days pulmonary changes precede renal damage.

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Serum Proteins in Cadmium Poisoned Rabbits

Cited by 27 publications

References 27 publications

Effect of Cadmium on Palmitic Acid Metabolism by Rat Liver Homogenate

Effect of Cadmium on Palmitic Acid Metabolism by Rat Liver Homogenate

Effects of subcutaneous and oral cadmium on iron metabolism: Role of ceruloplasmin and metallothionein

Early signs of oral and inhalative cadmium uptake in rats

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