Serum Protein Markers (Hp, GC, C3) in Patients with Colon Cancer

Abstract

The phenotypes and gene frequencies of three serum protein systems – Hp, GC and C3 – were studied in 184 consecutive patients from all over Greece with colon cancer. Healthy Greeks studied previously in our department served as controls. No significant differences were found between patients and controls concerning GC and C3. Significant differences were found in the Hp system; the frequencies of the Hp*1 gene and the Hp 1-1 phenotype were significantly higher in patients than in controls.

GC and C3 Serum Groups in Ulcerative Colitis

“…Electrophoret ic immunofixation on cellulose acetate strips, accord ing to Grumbaum and Zajak [10] It is interesting that similar results for Crohn's disease but not for ulcerative colitis were obtained by others [7] in a sample of 125 patients (72 with ulcerative colitis, 53 with Crohn's disease) examined. Positive associa tions of C3*F have also been found for other chronic inflammatory conditions such as rheumatoid arthritis and multiple sclerosis by others [12][13][14], and for peptic ulcer [2] and gastric cancer [3], but not for colon cancer [4] by our group. It has been reported [15] that C3F and C3S differed in their capacity to bind to mononuclear cells in vitro: C3F had an enhanced capacity to bind with the respec tive receptor on mononuclear cells.…”