Serum protein electrophoresis patterns in human immunodeficiency virus-infected individuals not on antiretroviral treatment

Zemlin, Annalise E; Ipp, Hayley; Maleka, Sechaba; Erasmus, Rajiv T

doi:10.1177/0004563214565824

Cited by 11 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are few articles with monoclonal bands in the gamma region in cases with malignancy and retroviral infections. [13,14] In nephropathy, in our study, the mean value was noted as 6.53 ± 0.96 which is on the lower side of the normal and was similar to the study done by Journal of Medical Sciences and Health/Jan-Apr 2016/Volume 2/Issue 1…”

Section: Tp and Other Protein Fractions In Various Clinical Conditionssupporting

confidence: 89%

A Comprehensive Approach towards Serum Protein Electrophoresis Reporting with Relative Percentage and Gram as Addendum

Furruqh¹,

Sharma²

2016

JMSH

View full text Add to dashboard Cite

Background and Objectives: Standardization for reporting serum protein electrophoresis (SPE) like many other specialized investigations is now a global issue with respect to many varied validated, methodologies, and different styles of reporting. Specific criteria or recommendations are needed which address, the changes in the variations in serum protein, albumin, globulin levels with respect to the wide reference range of these fractions expressed in g/dL. Hence, this study intends to evaluate the interpretation and significance of the reporting pattern of SPE by cellulose acetate method in a tertiary care hospital. Materials and Methods: A total of 470 cases requested for SPE by cellulose acetate method in College Lab, Department of Biochemistry, St. John's Medical College and Hospital were included in the study. Results: A significant association was observed between all the protein fractions and total protein (P < 0.001), though alpha 1 globulins does not. Also, observed that individual protein fractions showed correlation with gram and percentage expressions (r > 0.75). The majority of relative increase in protein fraction by percentage was observed for alpha 2 globulins (P < 0.05). However, relative decrease by percentage was seen only in albumin. Conclusion:It was seen that the SPE reporting could be enhanced with further information such as relative percentage to individualize the report and a note on the methodology to add specific information. Further studies are required to include general interpretive commenting, keeping in mind relative percentage, and small paraprotein bands.

show abstract

Section: Tp and Other Protein Fractions In Various Clinical Conditionssupporting

confidence: 89%

A Comprehensive Approach towards Serum Protein Electrophoresis Reporting with Relative Percentage and Gram as Addendum

Furruqh¹,

Sharma²

2016

JMSH

View full text Add to dashboard Cite

show abstract

“…Autoimmune phenomena arise from various pathogenetic mechanisms, including molecular mimicry, dysregulation of the interaction between B and T lymphocytes, as well as relentless immunoactivation due to lifelong infection with HIV (7)(8)(9). In the sera of HIV-infected patients various autoantibodies, e.g.…”

mentioning

confidence: 99%

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

Touzeau‐Roemer¹,

Skoll²,

Tajpara³

et al. 2019

Acta Derm Venerol

View full text Add to dashboard Cite

This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Acta Derm Venereol 2019; 99: 978-983 978 SIGNIFICANCEThe simultaneous occurrence of HIV-related immunodeficiency and autoimmune diseases is clearly documented. This cross-sectional study including 594 HIV-infected patients and 248 healthy controls lacking signs of autoimmune blistering skin diseases evaluated the frequency, titres and combinational appearance of autoantibodies directed against BP180, BP230, desmoglein 1 and 3, and showed no differences between the 2 patient groups. Interestingly, reactive syphilis serology in both HIV-infected individuals and uninfected controls was associated with positive anti-BP180 ELISA results, prompting a further evaluation for syphilis antibodies in patients with positive BP180 ELISA results and no clinical signs of bullous pemphigoid.Various autoantibodies are detected more frequently in HIV-infected individuals than in HIV-negative controls; however, limited data exist regarding autoimmune blistering skin diseases. Using enzyme-linked immunoassay (ELISA) and indirect immunofluore scence, no difference in the frequency and magnitude of autoantibodies against BP180, BP230, desmoglein 1 and 3 was found between 594 HIV-infected patients and 248 uninfected controls in this cross-sectional study (16.0% vs. 11.7%, respectively, for at least one positive ELISA, p = 0.11). Interestingly, reactive syphilis serology in both HIV-infected individuals and uninfected controls was associated with positive anti-BP180 ELISA results (adjusted odds ratio (OR) 2.14, 95% confidence interval (CI) 1.07-4.29, p = 0.03 and OR 4.70, CI 1.3-16.86; p = 0.0180). Our study shows a comparably low prevalence of cutaneous autoantibodies in both HIV-infected patients and uninfected controls lacking signs of autoimmune blistering skin disease. Positive BP180 ELISA in the absence of clinical signs of bullous pemphigoid should prompt further evaluation for syphilis antibodies.

show abstract

“…Previous studies on local HIV populations both treatment-naïve and on treatment have found abnormal serum protein electrophoresis patterns suggestive of polyclonal hypergammaglobulinaemia and increased IgG 40,41…”

Section: Discussionmentioning

confidence: 99%

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals

Hoffman¹,

Ipp²,

Phatlhane³

et al. 2018

Afr H. Sci.

Self Cite

View full text Add to dashboard Cite

BackgroundE-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.ObjectivesThis study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD).MethodsE-selectin levels were determined in 114 HIV-infected treatment-naive and 66 HIV-negative individuals, compared between groups and correlated with markers of disease severity, inflammation and coagulation.ResultsThere were statistically significant differences (p<0.01) in levels of WCC, CD4+ count, %CD38/8, albumin, IgG, hsCRP and D-dimer between groups and no statistically significant differences in E-selectin (p=0.84) and fibrinogen (p=0.65) levels. E-selectin correlated with age (p=0.02) and gender (p=0.01).ConclusionE-selectin was a poor marker in this setting. There was no correlation with any of the markers of disease severity, inflammation and coagulation. E-selectin is most likely raised in an acute inflammatory setting, rather than chronic stage of HIV-infection. We recommend that other markers be utilized to identify patients at increased risk of CVD; as these were significantly increased untreated in individuals.

show abstract

Serum protein electrophoresis patterns in human immunodeficiency virus-infected individuals not on antiretroviral treatment

Cited by 11 publications

References 23 publications

A Comprehensive Approach towards Serum Protein Electrophoresis Reporting with Relative Percentage and Gram as Addendum

A Comprehensive Approach towards Serum Protein Electrophoresis Reporting with Relative Percentage and Gram as Addendum

Prevalence of Skin-specific Autoantibodies in HIV-infected Patients and Uninfected Controls

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals

Contact Info

Product

Resources

About