serum protein changes during the acute phase reaction

Werner, Mario

doi:10.1016/0009-8981(69)90272-1

Cited by 134 publications

(39 citation statements)

References 14 publications

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“…However, despite the general nature of the groupings, there were obvious trends in protein alterations. These were usually consistent with results obtained by other workers (Easton et al, 1965;Laurell and Gronvall, 1962;Werner, 1969).…”

Section: Analysis Of a Random Hospital Populationsupporting

confidence: 93%

Specific Protein Determinations Using Immunoelectrophoresis

Driscoll

1973

Ann Clin Biochem

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The Laurell ‘rocket’ technique of immunoelectrophoresis has been used to quantitate seven specific serum proteins in a control population of SO healthy persons and in 100 hospital patients. Reference ranges have been established for each protein from data obtained from the control population. For many of the proteins variations due to age and/or sex were observed. Sex hormones, probably oestrogens, were also observed to cause variations in some of the protein concentrations. Data obtained from the hospital patients indicated that further work should prove profitable and could enable specific protein determinations to be useful, both as a diagnostic tool and in following the course of a disease.

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Section: Analysis Of a Random Hospital Populationsupporting

confidence: 93%

Specific Protein Determinations Using Immunoelectrophoresis

Driscoll

1973

Ann Clin Biochem

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“…It was quite possible that lipoproteins including Lp (a) were similarly changed due to denaturation. 2) In the immediate period following CPB all lipid, lipoprotein and apolipoprotein concentrations except Lp (a) remained significantly lower than the preoperative concentrations, in close agreement with results previously reported for major surgery, 2,6) infections, 2,7) burn injuries, 2,8) and myocardial infarction. 2,9) In that respect, CPB did not differ from major surgery and the effect of extracorporeal circulation and hemodilution on lipid metabolism several hours after the operation was minimal.The striking result of their study was the rise in Lp (a) levels at the initial period and throughout CPB.…”

supporting

confidence: 79%

Effect of Cardiopulmonary Bypass on Plasma Levels of Lipoprotein (a) in Hypercholesterolemic Patients.

et al. 2001

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SUMMARYIncrements of lipoprotein (a) (Lp (a)) concentration during cardiopulmonary bypass (CPB) have not been justified in the literature yet. We have investigated whether Lp (a) levels remain constant or increase during CPB and if high plasma levels of low density lipoprotein (LDL; containing apolipoprotein (apo) B) in hypercholesterolemic patients affect the assembly of Lp (a) (containing apoB: Apo (a)).In this study, the change in plasma lipid and lipoprotein levels of 40 patients with hypercholesterolemia and 40 patients who have normal cholesterol values were determined and compared during CPB, and in the postoperative early stage. In our study, lipid and lipoproteins, except Lp (a), showed a falling trend and paradoxically, Lp (a) statistically showed a significant rising trend, like the acute phase reactant in two groups (p=0.011 for LDL, p=0.016 for high density lipoprotein (HDL) and p<0.001 for the others, in 80 patients). Concentrations of Lp (a) in plasma increased more sharply in the hypercholesterolemic group than the normocholesterolemic group during CPB. This difference was significant at the 60 th minute of cardiopulmonary bypass with a nonparametric test (p<0.05 Mann-Whitney U test). High density lipoprotein values showed more decline in the hypercholesterolemic group patients than in the normocholesterolemic group patients (p<0.05). In conclusion, lipoprotein (a) levels increased more pronounced in patients with hypercholesterolemia during CPB. On the other hand, high LDL levels in hypercholesterolemic patients accelareted Lp (a) formation in the acute phase. (Jpn Heart J 2001; 42: 563-574) Key words: Lipoprotein (a) (Lp(a)), Low density lipoprotein (LDL), Cardiopulmonary bypass (CPB), Acute phase reactant, Hypercholesterolemia, Lipids and lipoproteins, Coronary artery bypass grafting (CABG) PREVIOUS studies have shown a decrease in plasma concentrations of total cholesterol, HDL and LDL-cholesterol following major surgical operations without using extracorporeal circulation and hemodilution.1-4) Decreases in apoAI and apoB have also been reported with concomitant increases in acute phase proteins such as oromucoid, α-1 antitrypsin, ceruloplasmin and C-reactive protein, following surgical procedures. 2,5) On the other hand, in the study of Maeda, et al Lp From

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“…It was estimated that the injury to the skin, abdominal wall, and peritoneum would be larger during OC and searched for an objective, quantitative parameter with which to evaluate the differences in surgical trauma. It was observed that serum CRP concentration was the most suitable parameter for this purpose because it is the plasma protein which rises most dramatically and consistently after surgical trauma [5,9].…”

Section: Discussionmentioning

confidence: 99%

“…CRP is very consistent in response and is, therefore, the most satisfactory single screening test for an "acute phase" reactant [5]. CRP is a component of normal serum [7], which rises more dramatically than any other protein after surgical trauma [8][9][10]11]. CRP begins to rise 4-12 h post-operatively, reaches the peak level after 24-72 h, and returns to normal after 2 weeks [8,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

Kohli

Bansal

Gupta

et al. 2014

JCDR

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Background: The recovery from laparoscopic cholecystectomy (LC) is rapid and most of the patients are discharged on the 1 st post-operative day. There is an increased concentration of certain serum proteins, known as acute-phase reactive proteins (APRP) during the post-operative period depends on the degree of tissue damage and the inflammatory reaction. There is a direct positive correlation between the concentrations of APRP, especially C-reactive protein (CRP), and the severity of inflammation. This study was done to study the levels of C -reactive protein and Total Leucocyte Count in patients operated either by Open Cholecystectomy (OC) and Laparoscopic Cholecystectomy (LC).

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serum protein changes during the acute phase reaction

Cited by 134 publications

References 14 publications

Specific Protein Determinations Using Immunoelectrophoresis

Specific Protein Determinations Using Immunoelectrophoresis

Effect of Cardiopulmonary Bypass on Plasma Levels of Lipoprotein (a) in Hypercholesterolemic Patients.

To Study the Levels of C - Reactive Protein and Total Leucocyte Count in Patients Operated of Open and Laparoscopic Cholecystectomy

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