Serum Prostate Specific Antigen level in Women with Polycystic Ovary Syndrome

Ibrahim, Wasan Wajdi; Salah, Raya Kh.; Abbas, Widad M.

doi:10.32007/jfacmedbagdad.582224

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The testosterone level showed a significant increase in the group of patients compared with the control group. This is consistent to study [14] . Who attributed the increase of this hormone to the weakness of fertility and reproduction in women, Another study has proved that androgen plays an effective role in the fertility of women, Androgen and its receptors are the main factors to regulate the normal growth of follicle and functional decline in the reserve of ovaries and primary ovarian insufficiency.…”

Section: Resultssupporting

confidence: 92%

Estimation of the hepcidin level and some Biochemical parameters in patients of polycystic ovary Syndrome in Kirkuk city

Tikriti¹,

Naji²

2019

Tikrit J. Pure Sci.

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Polycystic ovary Syndrome is a common disorder in the endocrine glands, which is characterized by the aggregation of small bags surrounded by theca internal layers bloated follicles . The level of hepcidin and some other biochemical parameters were examined in (60) patients In addition to (30) blood samples of healthy control . The results showed a significant decrease in hepcidin level as well as E2 and progesterone while there was a significant increase in prolactin and testosterone in polycystic ovarian syndrome patients Compared to healthy control. There was no correlation between hepcidin and all other parameters but there was some correlations among parameters used, there was positive correlations between FSH with LH and Testosterone as well as between E2 and Testosterone and between T4 and T3 .

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Section: Resultssupporting

confidence: 92%

Estimation of the hepcidin level and some Biochemical parameters in patients of polycystic ovary Syndrome in Kirkuk city

Tikriti¹,

Naji²

2019

Tikrit J. Pure Sci.

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Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis

et al. 2019

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We undertook a comprehensive search of all published original articles evaluating the diagnostic value of prostate-specific antigen (PSA) for the detection of polycystic ovary syndrome (PCOS). Finally, 25 studies with a total of 1865 participants (1104 cases and 761 controls) met the inclusion criteria. Mean serum PSA levels were significantly higher in PCOS women compared to healthy women [Standardized mean difference (SMD)=1.73 ng/ml, 95% CI=1.22 to 2.25, p<0.001]. Only 5 studies reported accuracy indicators and were included in the bivariate random-effects model; with a total of 509 samples that included 332 (65.22%) confirmed PCOS women. The sensitivity of serum PSA for the diagnosis of PCOS varied between 66.3 and 90.6%, and, the specificity ranged from 62.5–86.7%. Meta-analysis revealed a pooled sensitivity of 72.3% (95% CI 67.1–77.00%) and specificity of 74.6% (95% CI 67.5–80.8%) with an area under the summary ROC curve equal to 0.82 (95% CI 0.75–0.83). The summary estimates were 2.92 (95% CI 1.98–4.31) for positive LR and 0.37 (95% CI 0.26–0.51) for negative LR. The pooled estimate of diagnostic odds ratio (DOR) of serum PSA was 9.01 (95% CI 4.35–18.64). Considering the methodological weaknesses existed in studies, lack of sufficient data regarding the accuracy indicators, and the complexity of the exact pathophysiology of PSA secretion in women, the precise position of PSA, as a diagnostic test for the detection of PCOS, in clinical practice is undetermined, and further studies are still needed.

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Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

Raimondo¹,

Gentile²,

Esposito³

et al. 2021

IJERPH

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Bisphenols and phthalates affect androgen receptor-mediated signaling that directly regulates Kallikrein-Related serine Peptidase 3 (KLK3) secretion, indicating that environmental factors may play a role in KLK3 secretion. With the aim of obtaining preliminary data on whether KLK3 could serve as an early marker of environmental pollution effects, in 61 and 58 healthy women living in a high environmental impact (HEI) and low environmental impact (LEI) area, respectively, serum KLK3 levels at different phases of menstrual cycle were measured. KLK3 values resulted in always being higher in the HEI group with respect to the LEI group. These differences were particularly relevant in the ovulatory phase (cycle day 12°–13°) of the menstrual cycle. The differences in KLK3 values during the three phases of the menstrual cycle were significant in the LEI group differently from the HEI group. In addition, higher progesterone levels were observed in the LEI group with respect to the HEI group in the luteal phase, indicating an opposite trend of KLK3 and progesterone in this phase of the menstrual cycle. Although changes in KLK3 could also depend on other factors, these preliminary data could be an early indication of an expanding study of the role of biomarkers in assessing early environmental effects for female reproductive health.

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Serum Prostate Specific Antigen level in Women with Polycystic Ovary Syndrome

Cited by 3 publications

References 3 publications

Estimation of the hepcidin level and some Biochemical parameters in patients of polycystic ovary Syndrome in Kirkuk city

Estimation of the hepcidin level and some Biochemical parameters in patients of polycystic ovary Syndrome in Kirkuk city

Serum Prostate-Specific Antigen Level in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis

Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women?

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