Serum prostaglandin levels in asthmatic patients

Plasma Prostaglandin Concentrations in Allergic Bronchial Asthma

“…This is in clear contrast to hte results ob tained in a previous study [3], where PGE/F Tabic I. Plasma PG levels (ng/ml) and PGE/F ratios ratios in the serum were found to be signifi cantly lower in the asthmatics than in the normal controls.…”

“…The specificity of anti-PG antibodies may also affect PGE/F ratios as well as individual PG levels. The cross reactivity for PGE» of the anti-PGEj anti body used in the previous study [3] was sig nificantly lower than the cross-reactivity for PGB» of anti-PGB, (used to measure PGB] converted from PGE]) in the present study. Also, anti-PGF.," used in the previous study had a higher specificity than that used in the present study.…”

“…This hypothesis has been supported by one study employing the sera of asthmatic patients [3]. The present study, using plasma instead of serum, disclosed elevated PGE levels and PGE/F ratios in patients with allergic bronchial asthma, failing to confirm the proposed etiological role of PGs.…”

Plasma Concentrations of Prostaglandins E₂ and F_2α in Asthmatic Patients

“…[5], Dry et al [6) and Buisseret et al (4), who all used the same method (5). Other authors (1,23,25), how ever, showed considerably higher values which differ to a large extent. This is cer tainly due to the sampling conditions: lack of aspirin in the sampling medium (1,8,24], release of PG during the coagulation when the determinations are carried out on scrum [23; table III).…”

“…Studies of circulating PGs in asthmatic patients are rare [1,6,8,11,[23][24][25], espe cially if we consider the great number of in vestigations carried out in vitro, in animals and man [16,20], which were always limit ed to the determination in systemic venous blood. PGs are 'local' hormones, mediators, i.e.…”