Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma

Pirinççi, Necip; Kaba, Mehmet; Geçit, İlhan; Güneş, Mustafa; Yüksel, Mehmet Bilgehan; Tanık, Serhat; Arslan, Ayşe; Demır, Halit

doi:10.1177/0748233713498924

Cited by 25 publications

(18 citation statements)

References 45 publications

(53 reference statements)

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“…[41] Previously reported data suggest a significant decrease in the levels of anti-oxidative enzymes in serum of RCC patient. [36,42] Decreased levels of anti-oxidative enzymes (SOD, CAT, GSH and APOX) in the present finding can be a cause of progression of RCC in patients ( Figure 3). …”

Section: Discussionmentioning

confidence: 53%

Crosstalk Between Decreased Anti-Oxidant and Increased Serum Angiogenesis in Renal Cell Carcinomas

Awan¹

2017

WJPR

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Section: Discussionmentioning

confidence: 53%

Crosstalk Between Decreased Anti-Oxidant and Increased Serum Angiogenesis in Renal Cell Carcinomas

Awan¹

2017

WJPR

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“…The results indicated that an increased prolidase activity might be related to increased oxidative stress along with decreased antioxidant levels in renal cancer (41).…”

Section: Oxidative Stress and Prolidasementioning

confidence: 90%

Prolidase

Namiduru¹

2016

BLL

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Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position. Prolidase has a unique function in all cell types; therefore, the mechanisms and parameters involved in prolidase activity regulation are of special interest. Could prolidase be a good biomarker in different physiologic and pathologic conditions? This is an important question. There is no consensus on the answer to this question. It is of great importance during collagen turnover, infl ammation, tissue fi brosis and skeletal abnormalities. Prolidase itself without other biochemical markers may not provide information to clinicians about disease activity. So, I think it should be evaluated together with other serum biochemical markers. This review will serve to discuss many in vivo functions of prolidase, as well as level prolidase activity in diagnosis and monitoring of treatment in the various diseases (Ref. 50). Text in PDF www.elis.sk.

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“…The final step of collagen degradation is catalyzed by intracellular prolidase; therefore, it may be associated with neoplastic transformation. Increased prolidase activities have been observed in some of cancers, such as lung cancer [15] , breast cancer [16] , endometrial cancer [17] , stomach cancer [18] , renal cell cancer [19] and ovarian cancer [20] . On the other hand, Palka et al [6] showed reduced levels of prolidase in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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AIM:To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC). METHODS:Sixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm Prospective Study ORIGINAL ARTICLEand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at -80 ℃ until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay. RESULTS:In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels. CONCLUSION:Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. Core tip: Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver can...

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Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma

Abstract: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.

Cited by 25 publications

References 45 publications

Crosstalk Between Decreased Anti-Oxidant and Increased Serum Angiogenesis in Renal Cell Carcinomas

Crosstalk Between Decreased Anti-Oxidant and Increased Serum Angiogenesis in Renal Cell Carcinomas

Prolidase

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

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