Serum Prolactin in Patients with Rheumatoid Arthritis and its Association with Disease Activity

Fayez, Dalia; Habeeb, Reem A.; Hassan, Sameh; Abdelfatah, Noha

doi:10.21608/ejrci.2015.9315

Cited by 3 publications

(3 citation statements)

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“…Meanwhile, there was a non-significant difference in the DAS28 score on comparing lactating women using OCs with those non- lactating. Our results agree with Fayez et al who reported that increased level of serum prolactin was found in patients with high disease activity when compared to moderate and low disease activity and serum prolactin level was significantly correlated with DAS28 and ESR [20], also, Fojtíková et al reported that RA patients with active disease had high serum prolactin level which correlated significantly with disease activity and Larsen score [35]. Many previous studies have explored the effect of breastfeeding on disease activity during the postpartum period which is challenging for women suffering from rheumatologic diseases due to the increased risk of disease flare and limitations in the use of medications during breastfeeding [36].…”

Section: Discussionsupporting

confidence: 93%

“…Prolactin is a hormone which has a cytokine-like action and is considered as an immune-stimulatory agent that is involved in synovial hyperplasia and inflammation [17,18], it is secreted by the pituitary gland in addition to macrophages and lymphocytes located in the synovial tissue of inflammatory arthritis patients [19]. Prolactin has a role in the severity of the disease and enhances RA joint damage [20]. Clinical trials revealed significantly high serum prolactin in RA patients suggesting that prolactin may have a significant role in disease activity and also in the disease development process [21].…”

Section: Introductionmentioning

confidence: 99%

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Impact of oral contraceptives and breastfeeding on disease activity in a sample of Egyptian rheumatoid arthritis patients

Elsayed

Henry

Elfadl

2020

Egypt Rheumatol Rehabil

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Background Women are more affected by rheumatoid arthritis (RA) than men and the incidence of RA in women increases around the age of menopause indicating that hormonal factors may have a role in disease pathogenesis and progression. Despite several studies on the role of sex hormones and oral contraceptives (OCs) in RA patients, the effect of combined oral contraceptives on RA disease activity is still controversial, and since few studies have been performed in Egypt on this issue so we aimed to study the effect of OCs, breastfeeding, and prolactin on disease activity and their relation to the titer of autoantibodies in female Egyptian RA patients. Results One hundred twenty married female RA patients were classified into three groups based on the OCs use (n = 40 each); current, past and non-users and according to lactation into three groups; lactating using OCs (n = 22), lactating not using OCs (n = 30), and non-lactating (n = 68). Our patients were using combined estrogen-progestin oral contraceptives. Clinical manifestations, disease activity, and laboratory findings were determined. The clinical manifestations including arthritis, and morning stiffness were significantly reduced in current users in comparison to past and non-users. Mean DAS28 was reduced significantly (p < 0.05) in current and past users of OCs. Also, using OCs during lactation reduced the clinical manifestations significantly. Lactating women who were not using OCs had significantly high DAS28 and ESR (p < 0.05) in comparison to lactating using OCs and non-lactating. On the other hand, using OCs reduced serum prolactin significantly. Lactating women not using OCs had significantly high serum prolactin (p < 0.05) and (p < 0.001) in comparison to lactating using OCs and non-lactating respectively which was correlated with DAS28 score. Conclusion Oral contraceptives may be considered in RA female patients not only as a suitable birth control method but also it has a controlling effect on disease activity even during lactation. Message Oral contraceptives ameliorate disease activity in RA patients

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Impact of oral contraceptives and breastfeeding on disease activity in a sample of Egyptian rheumatoid arthritis patients

Elsayed

Henry

Elfadl

2020

Egypt Rheumatol Rehabil

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“…Vasoinhibin shows positive high significant correlation between vasoinhibin and both DAS28, CDAI (p<0.001). According to Fayez et al, [29]. study on 40 RA patients Serum prolactin concentrations in patients were significantly higher.…”

Section: Resultsmentioning

confidence: 94%

Prolactin Hormone and Vasoinhibin in Rheumatoid Arthritis Patients

2023

Al-Azhar University Journal of Virus Researches and Studies

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Rheumatoid Arthritis (RA) is a chronic autoimmune disease affecting synovial joints causing joint destruction, deformity that may lead to disability. There are many risk factors affecting RA including hormones as prolactin (PRL) and its proteolytic cleavage product known as vasoinhibin. This study was case control study conducted in Al-Azhar Rheumatology and Rehabilitation, clinical pathology departments for girls to assess levels of prolactin and vasoinhibin in serum of 60 rheumatoid arthritis patients versus 30 controls. Also, to assess the correlation of serum prolactin and vasoinhibin levels with laboratory and clinical parameters of rheumatoid arthritis patients. Our study revealed high positive statistically significant increase in PRL and vasoinhibin in patients than control. Prolactin showed positive significant correlation with number of tender joints and number of swollen joints, vasoinhibin, ESR, CRP, CDAI, DAS-28 with P-value<0.05. serum Vasoinhibin showed positive high statistical significance correlation with number of tender joints, number of swollen joints, patient and physician global assessments, ESR, DAS-28, CDAI with P-value <0.001, while with prolactin, VAS with P-value<0.05.

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Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management

Aloke

Ohanenye

Aja

et al. 2022

Journal of Pharmacy and Pharmacology

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Objectives Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation, pain, and cartilage and bone damage. There is currently no cure for RA. It is however managed using nonsteroidal anti-inflammatory drugs, corticosteroids and disease-modifying anti-rheumatic drugs, often with severe side effects. Hidden within Africa’s lush vegetation are plants with diverse medicinal properties including anti-RA potentials. This paper reviews the scientific literature for medicinal plants, growing in Africa, with reported anti-RA activities and identifies the most abundant phytochemicals deserving research attention. A search of relevant published scientific literature, using the major search engines, such as Pubmed/Medline, Scopus, Google Scholar, etc. was conducted to identify medicinal plants, growing in Africa, with anti-RA potentials. Key findings Twenty plants belonging to 17 families were identified. The plants are rich in phytochemicals, predominantly quercetin, rutin, catechin, kaempferol, etc., known to affect some pathways relevant in RA initiation and progression, and therefore useful in its management. Summary Targeted research is needed to unlock the potentials of medicinal plants by developing easy-to-use technologies for preparing medicines from them. Research attention should focus on how best to exploit the major phytochemicals identified in this review for the development of anti-RA ‘green pharmaceuticals’.

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Serum Prolactin in Patients with Rheumatoid Arthritis and its Association with Disease Activity

Cited by 3 publications

References 5 publications

Impact of oral contraceptives and breastfeeding on disease activity in a sample of Egyptian rheumatoid arthritis patients

Impact of oral contraceptives and breastfeeding on disease activity in a sample of Egyptian rheumatoid arthritis patients

Prolactin Hormone and Vasoinhibin in Rheumatoid Arthritis Patients

Phytochemicals from medicinal plants from African forests with potentials in rheumatoid arthritis management

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