Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment

Huang, Wei; Li, Yong-Hang; Huang, Shi-Qing; Chen, Hui; Li, Zaifang; Li, Xixi; Li, Xuesong; Cheng, Yong

doi:10.1007/s12031-020-01739-w

Cited by 7 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treatment response group was significantly negatively predicted by the estradiol blood levels, and the treatment nonresponse group showed a positive association with the FSH blood levels. More recently, Huang et al [16] found serum progesterone levels to be negatively associated with the PANSS total scores, which suggests a correlation between the progesterone hormone levels and the disease severity of schizophrenia [16], which is seemingly in line with Gogos et al [17]. In their review, the authors emphasize that estradiol and progesterone may be dysregulated in major psychiatric disorders, such as, for instance, schizophrenia.…”

Section: Introductionmentioning

confidence: 73%

“…In a study by Huang et al [ 16 ], the serum progesterone levels were negatively associated with psychotic symptoms, as they are measured by the PANSS total scores, which suggests a correlation between the hormone levels and the severity of the schizophrenia. Similar results have been described with regard to first-episode psychosis patients.…”

Section: Resultsmentioning

confidence: 99%

“…It has been suggested that 17-beta-estradiol has antipsychotic activity as it has organizational and activational effects via genomic and nongenomic mechanisms [ 17 ]. Progesterone has been also negatively associated with psychotic symptoms [ 16 ], and, in the context of menopause (characterized by a higher testosterone-to-estradiol ratio), testosterone levels have been associated with higher frequencies of depressive symptoms [ 43 ]. However, in our review, we found that the effects of estradiol, progesterone, and other sex hormones have not been sufficiently investigated in the field of sleep disorders in postmenopausal women with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.

show abstract

Section: Introductionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Testosterone is a major sex differentiation hormone in vertebrates, and is commonly detected in the haemolymph and testis. Testosterone is essential for sexual development in males ( Shalender and Stuart 2019 ; Huang et al, 2021 ). The dose of LH-A2 at 3 μg/kg stimulated the secretion of E2 in A .…”

Section: Discussionmentioning

confidence: 99%

Effects of Luteinizing Hormone Releasing Hormone A2 on Gonad Development in Juvenile Amur Sturgeon, Acipenser schrenckii, Revealed by Transcriptome Profiling Analysis

Jin

Cao

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Acipenser schrenckii is an economically important aquatic species whose gonads require particularly long times to reach sexual maturity. Luteinizing hormone plays important roles in gonad development, and luteinizing hormone releasing hormone A2 (LH-A2) is used as an oxytocin to promote ovulation in aquaculture of A. schrenckii. In this study, we aimed to determine the effects of LH-A2 on gonad development in juvenile A. schrenckii through transcriptome profiling analysis of the pituitary and gonads after LH-A2 treatment at a dose of 3 μg/kg. The 17β-estradiol (E2) levels gradually increased with LH-A2 treatment time, and significantly differed from those of the control group on days 5 and 7 (p < 0.01). However, the content of testosterone (Testo) gradually decreased with LH-A2 treatment time and showed significant differences on day 3 (p < 0.05), and on days 5 and 7 (p < 0.01), compared to those in the control group. Thus, LH-A2 promotes the secretion of E2 and inhibits the secretion of Testo. Transcriptome profiling analysis revealed a total of 2,883 and 8,476 differentially expressed genes (DEGs) in the pituitary and gonads, respectively, thus indicating that LH-A2 has more regulatory effects on the gonads than the pituitary in A. schrenckii. Signal transduction, global and overview maps, immune system, endocrine system and lipid metabolism were the main enriched metabolic pathways in both the pituitary and gonads. Sixteen important genes were selected from these metabolic pathways. Seven genes were co-DEGs enriched in both signal transduction and endocrine system metabolic pathways. The other co-DEGs were selected from the immune system and lipid metabolism metabolic pathways, and showed mRNA expression changes of >7.0. The expression of five DEGs throughout LH-A2 treatment was verified to show the same patterns of change as those observed with RNA-seq, indicating the accuracy of the RNA-seq in this study. Our findings provide valuable evidence of the regulation of gonad development of juvenile A. schrenckii by LH-A2 and may enable the establishment of artificial techniques to regulate gonad development in this species.

show abstract

“…Some of the hormones are thought to directly correlate to mental disorder, but the inner mechanism is still unclear. For example, the results showed that schizophrenia patients had significantly increased testosterone levels when compared with healthy control subjects ( Huang et al, 2021 ). Another research has found that mean total testosterone serum levels were significantly higher in bipolar disorder patients in comparison with major depressive disorder patients ( Flores-Ramos et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Attractin Participates in Schizophrenia by Affecting Testosterone Levels

Gao

Wang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Attractin (ATRN) is a widely expressed glycoprotein that is involved in energy homeostasis, neurodevelopment, and immune response. It is encoded by a gene spanning 180 kb on chromosome 20p13, a region previously implicated in schizophrenia by linkage studies. To address a possible role of ATRN in disorders of the central nervous system, we created an atrn knockout zebrafish line and performed behavioral tests. Adult atrn–/– zebrafish exhibited more pronounced attack behavior relative to wild-type control zebrafish in a tracking analysis. Biochemical analysis revealed elevated testosterone levels in atrn–/– zebrafish. At the gene expression level, we noted an upregulation of cyp51 and hsd17b7, key proteins in testosterone synthesis in the brains of both adult and larvae of atrn–/– zebrafish. In order to further elucidate the relationship between testosterone and behavioral syndromes, we then compared testosterone levels of 9,008 psychiatric patients and 247 healthy controls from the same catchment area. Of all subjects examined, male subjects with schizophrenia exhibited lower testosterone levels compared with controls. In contrast, female subjects with a diagnosis of schizophrenia or bipolar disorder featured higher testosterone levels than did same sex controls. Purposeful sampling of extreme groups showed reduced ATRN expression in a subset of these subjects. Finally, we identified 14 subjects with ATRN mutations. All of whom displayed abnormal testosterone levels. In summary, the interplay of ATRN and testosterone may help to explain sexual dimorphisms in selected behavioral phenotypes.

show abstract

Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment

Cited by 7 publications

References 22 publications

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review

Effects of Luteinizing Hormone Releasing Hormone A2 on Gonad Development in Juvenile Amur Sturgeon, Acipenser schrenckii, Revealed by Transcriptome Profiling Analysis

Attractin Participates in Schizophrenia by Affecting Testosterone Levels

Contact Info

Product

Resources

About