Serum Presepsin, Proadrenomedullin and Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as Biomarkers for the Diagnosis of Acute Pyelonephritis

Cetın, Nuran; Kiraz, Zeynep Küskü; Gencler, Aylin

doi:10.1007/s13312-020-1914-7

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…It was also reported that sTREM-1 levels did not differ between patients with lower and upper UTIs [14]. Another study of children with acute pyelonephritis indicated that elevated TREM-1 levels exhibited high positive predictive values [29]. In the current study, basal sTREM-1 levels demonstrated acceptable diagnostic performance in distinguishing patients with ASP.…”

Section: Discussionsupporting

confidence: 55%

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

Özsoy,

Ataman,

Şahin

et al. 2024

Diagnostics

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Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a new biomarker that can be used for the diagnosis and monitoring of urinary system infections. This study aimed to evaluate the diagnostic performance of serum sTREM-1 in patients with a diagnosis of acute stone pyelonephritis (ASP). This prospective study included 46 patients with a diagnosis of ASP and a control group of 23 individuals without urinary system infection. Blood samples were taken from participants upon hospital admission, and basal serum sTREM-1 levels were analyzed using the ELISA method. Serum sTREM-1 concentrations were measured after treatment of ASP patients. Basal leukocyte counts, C-reactive protein (CRP) levels, procalcitonin (PCT), and sTREM-1 (98.6 vs. 68.4 pg/mL, p < 0.001) levels were higher in the ASP group compared to the control group. After treatment, the median leukocyte counts, PCT, and sTREM-1 levels decreased and were similar to those of the control group. The median CRP level also decreased after treatment, but it remained higher than that of the control group. In predicting patients with ASP, the baseline sTREM-1 exhibited a sensitivity of 74.6% and a specificity of 78.2%, while its diagnostic performance was lower than that of leukocyte counts, CRP, and PCT. Despite the findings that levels of sTREM-1 were higher upon hospital admission in patients with ASP and significantly decreased after treatment, the utility of sTREM-1 as a biomarker for predicting patients with ASP remains constrained when compared to established inflammatory markers.

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Section: Discussionsupporting

confidence: 55%

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

Özsoy,

Ataman,

Şahin

et al. 2024

Diagnostics

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“…Regarding plasma levels, in one study proADM levels had good predictive value for the diagnosis of APN among patients with UTI (AUC = 0.830, cut-off value for proADM of 63.86 pg/mL [ 26 ]. A later study by Peñalver R. et al could not find a relationship between APN and plasma ADM; however, they did find that plasma MR-proADM had excellent prognostic capacity to predict RS development in patients with APN.…”

Section: Resultsmentioning

confidence: 99%

“…In patients with acute abdomen, its combined use with CRP is proposed to identify low-risk patients [ 17 , 18 ]. Finally, in UTIs, it seems to identify patients with pyelonephritis and patients with pyelonephritis who will develop renal scarring [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

2022

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Adrenomedullin has several properties. It acts as a potent vasodilator, has natriuretic effects, and reduces endothelial permeability. It also plays a role in initiating the early hyperdynamic phase of sepsis. Since its discovery, many articles have been published studying the uses and benefits of this biomarker. The aim of this review is to determine the usefulness of adrenomedullin in pediatric patients. Relevant studies covering adrenomedullin in pediatrics (<18 years) and published up until August 2021 were identified through a search of MEDLINE, PubMed, Embase, Web of Science, Scopus, and Cochrane. Seventy studies were included in the present review, most of them with a low level of evidence (IV to VI). Research on adrenomedullin has primarily been related to infection and the cardiovascular field. The performance of adrenomedullin to quantify infection in children seems satisfactory, especially in sepsis. In congenital heart disease, this biomarker seems to be a useful indicator before, during, and after cardiopulmonary bypass. Adrenomedullin seems to be useful in the pediatric population for a large variety of pathologies, especially regarding infection and cardiovascular conditions. However, it should be used in combination with other biomarkers and clinical or analytical variables, rather than as a single tool.

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Serum Presepsin, Proadrenomedullin and Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as Biomarkers for the Diagnosis of Acute Pyelonephritis

Cited by 2 publications

References 13 publications

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis

A Review of Adrenomedullin in Pediatric Patients: A Useful Biomarker

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