Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmö Preventive Project Cohort

Johnson, Linda; Mattsson, Nick; Sajadieh, Ahmad; Wollmer, Per; Söderholm, Martin

doi:10.1161/strokeaha.117.018148

Cited by 24 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…38 Study also showed that low serum K is associated with stroke in people with cardiovascular disease, hypertension and diabetes mellitus. 39 Our results showed that MgSO 4 therapy could prevent hypokalemia in MgSO 4 -treated groups. There was a positive association between free thyroxine levels in middle-aged and elderly subjects and atherosclerosis throughout the whole disease spectrum, which was not dependent on cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 50%

<p>Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study</p>

Sobhani¹,

Farshidi²,

Azarkish³

et al. 2020

CPAA

View full text Add to dashboard Cite

Purpose: Given the beneficial effect of MgSO 4 on the cardiovascular system, this study was designed to investigate the effect of MgSO 4 administration on suppressing some atherosclerotic risk factors in moderate coronary artery disease patients with one or two atherosclerotic vessels. Patients and Methods: In a randomized double-blind placebo-controlled clinical trial study, 64 patients with moderate coronary artery disease (55-69% stenosis) were selected according to angiography findings. Patients were divided into four groups including patients with one or two atherosclerotic vessels treated with MgSO 4 (Mg-treated-VR1, Mg-treated-VR2, respectively), placebo treated patients with one or two atherosclerotic vessels (Control-VR1, Control-VR2, respectively). The patients received either placebo or MgSO 4 supplement capsule containing 300 mg MgSO 4 for six months on a daily basis. ESR, Ca/Mg ratio, urine Mg level, serum Mg, fibrinogen, homocysteine, uric acid, Na, K, Ca, CRP, T3, T4, TSH, BUN, and Cr concentrations were measured at baseline and every three months. Results: Serum T3, Ca, K, homocysteine, CRP, and Mg concentrations were significantly improved in Mg-treated groups compared to placebo groups. Conclusion: The results of this study showed that despite the slight change in serum magnesium level, oral administration of MgSO 4 for six months could slightly reduce the serum levels of some inflammatory and vascular factors in moderate coronary artery disease patients.

show abstract

Section: Discussionmentioning

confidence: 50%

<p>Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study</p>

Sobhani¹,

Farshidi²,

Azarkish³

et al. 2020

CPAA

View full text Add to dashboard Cite

show abstract

“…Besides, hyperkalemia is a threatening symptom in ESRD resulting due to reduced kidney function and conditions like the transcellular shift in insulin deficiency. The population-based reports of the Malmo preventive project cohort study showed a positive and significant association between the elevation of serum potassium per mmol/l and an increase in stroke (ischemic and hemorrhagic) risk and mortality (Johnson et al, 2017). Dysnatremia, especially hyponatremia, has significant mortality pertaining to a risk factor in stroke (Zhang et al, 2015).…”

Section: Acid-base Balancementioning

confidence: 99%

Cerebro‐renal interaction and stroke

Shah

Jagtap

Sarmah

et al. 2020

Eur J of Neuroscience

View full text Add to dashboard Cite

Stroke is an event causing a disturbance in cerebral function leading to death and disability worldwide. Both acute kidney injury and chronic kidney disease (CKD) are associated with an increased risk of stroke and cerebrovascular events. The underlying mechanistic approach between impaired renal function and stroke is limitedly explored and has attracted researchers to learn more for developing therapeutic intervention. Common risk factors such as hypertension, hyperphosphatemia, atrial fibrillation, arteriosclerosis, hyperhomocysteinemia, blood-brain barrier disruption, inflammation, etc. are observed in the general population, but are high in renal failure patients. Also, risk factors like bone mineral metabolism, uremic toxins, and anemia, along with the process of dialysis in CKD patients, eventually increases the risk of stroke. Therefore, early detection of risks associated with stroke in CKD is imperative, which may decrease the mortality associated with it. This review highlights mechanisms by which kidney dysfunction can lead to cerebrovascular events and increase the risk of stroke in renal impairment.

show abstract

“… Drugs are involved in 80.5% of hospital-acquired hyperkalemia in older patients. Among these drug-induced hyperkalemia: (1) 79.2% are multifactorial through the combination of at least one drug with a precipitating factors; and (2)  Prevention of hospital-acquired hyperkalemia needs to take account of precipitating factors during the medication reconciliation by pharmacist. Drug dosage may be adapted or the drug may be stopped during acute illnesses in order to avoid the adverse reaction.…”

Section: What Does This Study Add To Our Knowledge?mentioning

confidence: 99%

“…Hyperkalemia is an electrolyte disorder that is frequently observed in a hospital setting, where it is associated with a 40% elevation in the death rate . In particular, polymedication and multiple comorbidities increase the risk of hyperkalemia in older patients .…”

Section: Introductionmentioning

confidence: 99%

“…Hyperkalemia is an electrolyte disorder that is frequently observed in a hospital setting, where it is associated with a 40% elevation in the death rate. 1,2 In particular, polymedication and multiple comorbidities increase the risk of hyperkalemia in older patients. 3 Hyperkalemia events are often related to adverse drug reactions (ADRs) 3,4 ; depending on the definition of hyperkalemia used and the type of patient included, a drug is reportedly involved in 31-66% of cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hospital‐Acquired Hyperkalemia Events in Older Patients Are Mostly Due to Avoidable, Multifactorial, Adverse Drug Reactions

Robert

Ficheur

Décaudin

et al. 2018

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

Drug-induced hyperkalemia is a frequent and severe complication in the hospital setting. Other risk factors may also induce hyperkalemia but the combination of drugs and precipitating factors has not been extensively studied. The aim was to identify drug-induced hyperkalemia events in hospitalized older patients and to describe their combinations with precipitating factors. Two experts independently analyzed retrospective data of patients aged 75 years or more. Experts identified 471 hyperkalemia events and concluded that 379 (80.5%) were induced by drugs. The cause was multifactorial (i.e., at least one drug with a precipitating factor) in 300 (79.2%) of the 379 drug-induced hyperkalemia. Most of the drug-induced hyperkalemia events were avoidable (79.9%)-mainly because of the multifactorial cause (e.g., dosage adaptation during acute kidney injury). Drug-induced hyperkalemia events are frequently combined with precipitating factors in hospitalized older patients and their prevention should focus on these combinations.

show abstract

Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmö Preventive Project Cohort

Cited by 24 publications

References 29 publications

<p>Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study</p>

<p>Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study</p>

Cerebro‐renal interaction and stroke

Hospital‐Acquired Hyperkalemia Events in Older Patients Are Mostly Due to Avoidable, Multifactorial, Adverse Drug Reactions

Contact Info

Product

Resources

About