Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status

Byun, Jeong Ah; Choi, Man Ho; Moon, Myeong Hee; Chung, Bong Chul

doi:10.1016/j.canlet.2008.08.024

Cited by 32 publications

(16 citation statements)

References 21 publications

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“…However, the sensitive and selective detection of spermine is greatly hindered by its low molecular weight, low volatility and lack of chromophores. Although the spermine is currently detected using immunoassays51 and chromatographic techniques475253, these are time-consuming, tedious procedures, involving expensive equipment.…”

Section: Resultsmentioning

confidence: 99%

A supramolecular approach to fabricate highly emissive smart materials

Yao

Kang

et al. 2013

Sci Rep

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The aromatic chromophores, for example, perylene diimides (PDIs) are well known for their desirable absorption and emission properties. However, their stacking nature hinders the exploitation of these properties and further applications. To fabricate emissive aggregates or solid-state materials, it has been common practice to decrease the degree of stacking of PDIs by incorporating substituents into the parent aromatic ring. However, such practice often involves difficultorganic synthesis with multiple steps. A supramolecular approach is established here to fabricate highly fluorescent and responsive soft materials, which has greatly decreases the number of required synthetic steps and also allows for a system with switchable photophysical properties. The highly fluorescent smart material exhibits great adaptivity and can be used as a supramolecular sensor for the rapid detection of spermine with high sensitivity and selectivity, which is crucial for the early diagnosis of malignant tumors.

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Section: Resultsmentioning

confidence: 99%

A supramolecular approach to fabricate highly emissive smart materials

Yao

Kang

et al. 2013

Sci Rep

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“…However, the function of such high concentrations of polyamines in tumour cells is not clear. In a study addressed to evaluate the variation of polyamines in the pre and post-surgery serum of BC patients, no significant difference was reported [32]. This suggests that the circulatory level of polyamines is more likely to represent an individual's general physio-pathological condition.…”

Section: Discussionmentioning

confidence: 99%

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

et al. 2016

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Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate to guide patient selection for personalized cancer treatments. In the present study, we applied a pharmacometabolomics approach to identify biomarkers potentially associated with pathological complete response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer patients. Based on histological response the 34 patients enrolled in the study were subdivided into two groups: good responders (n = 15) and poor responders (n = 19). The pre-treatment serum targeted metabolomics profile of all patients were analyzed by liquid chromatography tandem mass spectrometry and the differences in the metabolomics profile between the two groups was investigated by multivariate partial least squares discrimination analysis. The most relevant metabolites that differentiate the two groups of patients were spermidine and tryptophan. The Good responders showed higher levels of spermidine and lower amounts of tryptophan compared with the poor responders (p < 0.001, q < 0.05). The serum level of these two metabolites identified patients who achieved a pathological complete response with a sensitivity of 90% [0.79–1.00] and a specificity of 0.87% [0.67–1.00]. These preliminary results support the role played by the individual patients' metabolism in determining the response to cancer treatments and may be a useful tool to select patients that are more likely to benefit from the trastuzumab-paclitaxel treatment.

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“…25 A previous study found that urinary DiAcSpm values are higher in women than in men, whereas postmenopausal women had lower concentrations than premenopausal ones. 26 Accordingly, Byun et al 27 showed that patients with premenopausal breast cancer had higher (free and monoacetylated) polyamine levels in serum than postmenopausal ones, whose polyamine levels were similar to healthy controls. In our study, all women were postmenopausal, but 7 of them used hormone replacement therapy, creating a potential bias.…”

Section: Discussionmentioning

confidence: 99%

Urinary Polyamines as Biomarkers for Ovarian Cancer

Niemi

Roine

Häkkinen

et al. 2017

Int J Gynecol Cancer

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ObjectivesElevated concentrations of polyamines have been found in urine of patients with malignant tumors, including ovarian cancer. Previous research has suffered from poorly standardized detection methods. Our liquid chromatography–tandem mass spectrometry (LC-MS/MS) method is capable of simultaneous standardized analysis of most known polyamines. Liquid chromatography–tandem mass spectrometry has not previously been used in the differential diagnostics of ovarian tumors in postmenopausal women.Materials and MethodsIn this prospective study, postmenopausal women (n = 71) presenting with an adnexal mass and, as controls, women with genital prolapse or urinary incontinence scheduled for surgery (n = 22) were recruited in the study. For analysis of the polyamines, a morning urine sample was obtained before surgery. Preoperative serum CA125 concentrations were determined in the study group.ResultsTwenty-three women with benign and 37 with malignant ovarian tumors were eligible. Of all analyzed polyamines, only urinary N1,N12-diacetylspermine showed statistically significant differences between all groups except controls versus benign tumors. N1,N12-diacetylspermine was elevated in malignant versus benign tumors (P < 0.001), in high-grade versus low malignant potential tumors (P < 0.001), in stage III to IV versus stage I to II cancers (P < 0.001), and even in early-stage cancer (stage I–II) versus benign tumors (P = 0.017). N1,N12-diacetylspermine had better sensitivity (86.5%) but lower specificity (65.2%) for distinguishing benign and malignant ovarian tumors than CA125 with a cut-off value of 35 kU/L (sensitivity, 75.7%; specificity, 69.6%).ConclusionsUrinary N1,N12-diacetylspermine seems to be able to distinguish benign and malignant ovarian tumors as well as early and advanced stage, and low malignant potential and high-grade ovarian cancers from each other, respectively.

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Serum polyamines in pre- and post-operative patients with breast cancer corrected by menopausal status

Cited by 32 publications

References 21 publications

A supramolecular approach to fabricate highly emissive smart materials

A supramolecular approach to fabricate highly emissive smart materials

Pharmacometabolomics study identifies circulating spermidine and tryptophan as potential biomarkers associated with the complete pathological response to trastuzumab-paclitaxel neoadjuvant therapy in HER-2 positive breast cancer

Urinary Polyamines as Biomarkers for Ovarian Cancer

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