Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes

Grip, Tove; Dyrlund, Thomas Sparholt; Ahonen, Linda; Domellöf, Magnus; Hernell, Olle; Hyötyläinen, Tuulia; Knip, Mikael; Lönnerdal, Bo; Orešič, Matej; Timby, Niklas

doi:10.1038/s41390-018-0130-9

Cited by 33 publications

(28 citation statements)

References 42 publications

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“…In contrast, BF infants had higher levels of triglycerides and cholesterol in serum, as well as higher LDL:HDL ratios and leptin:fat mass ratios. Furthermore, infants who consumed EF showed a different circulating lipidomics profile 16 , as well as higher serum cholesterol and triglyceride levels compared to the SF-fed infants that approached what was observed in the BF infants 17 (Primary and secondary outcome measures from this cohort were previously published, and are summarized in Table 1).…”

Section: Introductionmentioning

confidence: 81%

Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial

Parenti

Grip

et al. 2019

Sci Rep

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Formula-fed (FF) infants exhibit a different metabolic profile than breast-fed (BF) infants. Two potential mechanisms are the higher protein level in formula compared with breast milk and the removal of the milk fat and associated milk fat globule membranes (MFGM) during production of infant formula. To determine whether MFGM may impact metabolism, formula-fed infants were randomly assigned to receive either an MFGM isolate-supplemented experimental formula (EF) or a standard formula (SF) from 2 until 6 months and compared with a BF reference group. Infants consuming EF had higher levels of fatty acid oxidation products compared to infants consuming SF. Although the protein level in the study formula was approximately 12 g/L (lower than most commercial formulas), a metabolic difference between FF and BF remained such that FF infants had higher levels of amino acid catabolism by-products and a low efficiency of amino acid clearance (preference for protein metabolism). BF infants had higher levels of fatty acid oxidation products (preference for fat metabolism). These unique, energy substrate-driven metabolic outcomes did not persist after diet was shifted to weaning foods and appeared to be disrupted by complementary feeding. Our results suggest that MFGM may have a role in directing infant metabolism.

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Section: Introductionmentioning

confidence: 81%

Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial

Parenti

Grip

et al. 2019

Sci Rep

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“…Cognitive assessment at 12 months of age with the Bayley-III Scales showed significantly higher mean cognitive domain scores in the MFGM-fed group vs. the control group, with no significant differences in the four other developmental domains, demonstrating that there was no evidence for adverse effects to either health or neurodevelopmental outcomes. Investigations into the cardiometabolic profile [155], oral microbiome [157], the fecal microbiome and metabolome [166], serum metabolome [166], and serum, plasma, and erythrocyte lipidome [167] have additionally been described.…”

Section: Mfgm Formula Group Did Notmentioning

confidence: 99%

“…The studies summarized here included over 1000 children assigned to MFGM supplementation. Seven of these studies [7,9,155,156,159,161,165] initiated feeding with MFGM-enriched formula at <2 months of age, and five [7,157,159,167] used the same source of MFGM ingredient. Though the majority of studies were designed to follow health and safety outcomes to endpoints of 12 or 18 months, the longest-term follow-ups to date from MFGM feeding in infancy now extend to 6 and 13 years of age [11].…”

Section: Mfgm Formula Group Did Notmentioning

confidence: 99%

Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

Fontecha

Brink

et al. 2020

Nutrients

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Research on milk fat globule membrane (MFGM) is gaining traction. The interest is two-fold; on the one hand, it is a unique trilayer structure with specific secretory function. On the other hand, it is the basis for ingredients with the presence of phospho- and sphingolipids and glycoproteins, which are being used as food ingredients with valuable functionality, in particular, for use as a supplement in infant nutrition. This last application is at the center of this Review, which aims to contribute to understanding MFGM’s function in the proper development of immunity, cognition, and intestinal trophism, in addition to other potential effects such as prevention of diseases including cardiovascular disease, impaired bone turnover and inflammation, skin conditions, and infections as well as age-associated cognitive decline and muscle loss. The phospholipid composition of MFGM from bovine milk is quite like human milk and, although there are some differences due to dairy processing, these do not result in a chemical change. The MFGM ingredients, as used to improve the formulation in different clinical studies, have indeed increased the presence of phospholipids, sphingolipids, glycolipids, and glycoproteins with the resulting benefits of different outcomes (especially immune and cognitive outcomes) with no reported adverse effects. Nevertheless, the precise mechanism(s) of action of MFGM remain to be elucidated and further basic investigation is warranted.

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“…SM and PC are a source of choline, an important nutrient in brain cell membranes and for the synthesis of neurotransmitters such as acetylcholine, neurogenesis and synaptogenesis [ 40 ]. MFGM supplementation between 2 and 6 months of age resulted in higher concentration of SM, PC and ceramide species in plasma at 6 months of age, higher concentration of SM and PC species in serum at 4 months of age but not at 12 months of age, and higher concentrations of SM, PE and PC species in erythrocyte membranes at 6 months of age but not at 12 months of age [ 93 ]. These results support a role for MFGM lipids in immune and cognitive outcomes reported by [ 37 , 58 ].…”

Section: Role Of Milk Fat and Mfgm In Infant Nutrition Growth Andmentioning

confidence: 99%

Whole Goat Milk as a Source of Fat and Milk Fat Globule Membrane in Infant Formula

2020

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Cow milk is the most common dairy milk and has been extensively researched for its functional, technological and nutritional properties for a wide range of products. One such product category is infant formula, which is the most suitable alternative to feed infants, when breastfeeding is not possible. Most infant formulas are based on cow milk protein ingredients. For several reasons, consumers now seek alternatives such as goat milk, which has increasingly been used to manufacture infant, follow-on and young child formulas over the last 30 years. While similar in many aspects, compositional and functional differences exist between cow and goat milk. This offers the opportunity to explore different formulations or manufacturing options for formulas based on goat milk. The use of whole goat milk as the only source of proteins in formulas allows levels of milk fat, short and medium chain fatty acids, sn-2 palmitic acid, and milk fat globule membrane (MFGM) to be maximised. These features improve the composition and microstructure of whole goat milk-based infant formula, providing similarities to the complex human milk fat globules, and have been shown to benefit digestion, and cognitive and immune development. Recent research indicates a role for milk fat and MFGM on digestive health, the gut–brain axis and the gut–skin axis. This review highlights the lipid composition of whole goat milk-based infant formula and its potential for infant nutrition to support healthy digestion, brain development and immunity. Further work is warranted on the role of these components in allergy development and the advantages of goat milk fat and MFGM for infant nutrition and health.

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Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes

Abstract: The effect of MFGM supplementation on the lipidome is likely part of the mechanisms behind the positive cognitive and immunological effects of feeding the EF previously reported in the same study population.

Cited by 33 publications

References 42 publications

Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial

Metabolic phenotype of breast-fed infants, and infants fed standard formula or bovine MFGM supplemented formula: a randomized controlled trial

Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

Whole Goat Milk as a Source of Fat and Milk Fat Globule Membrane in Infant Formula

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