Serum Placental Lactogen (HPL) Levels as an Index of Placental Function

Saxena, B.N.; Emerson, Kendall; Selenkow, Herbert A.

doi:10.1056/nejm196907312810501

Cited by 152 publications

(45 citation statements)

References 20 publications

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“…As expected [35], in the study group women, hPL levels increased progressively and significantly during the pregnancy (table 2). Prolactin secretion also significantly increased during the pregnancy in the study group women (fig.…”

Section: Resultssupporting

confidence: 87%

Pattern of Bone Markers during Pregnancy and Their Changes after Delivery

et al. 2003

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Objective: To investigate whether bone resorption markers change during pregnancy and lactation, and how they are correlated with human placental lactogen (hPL) and PRL. Subjects: Young women before pregnancy, during pregnancy and during a 12-month post-delivery period (study group; n = 22); and age- and weight-matched normal cycling women (control group; n = 22) for a 20-month-period participated in the study. Results: In the study group, women both during pregnancy (from the 8th up to the 38th week) and during a 6-month period of lactation, pyridinoline and deoxypyridinoline urinary levels were significantly higher than those of pre-pregnancy and control women. They returned to basal values at the 12th post-delivery month. During pregnancy there were early and late peak increases, at the 8th and 32nd week, respectively. At the 32nd, 34th, 36th and 38th week of pregnancy, pyridinoline and deoxypyridinoline urinary values were significantly correlated with hPL serum levels. Conclusions: During pregnancy the maternal bone resorption seems to vary critically at early and late stages. A complete reversal of these variations seems to occur after lactation. Further studies could evaluate if changes in placental function are capable of differently interfering with maternal bone resorption.

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Section: Resultssupporting

confidence: 87%

Pattern of Bone Markers during Pregnancy and Their Changes after Delivery

et al. 2003

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“…The presence of large amounts of placental lactogen in the serum of pregnant women has been reported by many authors (Beck et al, 1965;Kaplan & Grumbach, 1965;Samaan et al, 1966;Spellacy et al, 1966;Saxena et al, 1969;Geiger et al, 1971;Spona & Janisch, 1971;Sato, 1973). Shiu et al(1973) estimated the serum level of rat placental lactogen to be as high as 1584ng/ml, using a radioreceptor assay.…”

Section: Synopsismentioning

confidence: 75%

Synthesis of Two Lactogenic Proteins by the Mouse Placenta <I>in vitro</I>

Kohmoto

1975

Endocrinol Japon

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“…Elevated levels of HPL were reported by Singer et al (1970) in five out of 13 diabetic patients; in the one pregnancy which terminated unsuccessfully the mother had a normal HPL level at 35 weeks. Saxena et al (1969) also described increased levels in a series of 12 diabetic mothers.…”

Section: (B) In the Third Trimestermentioning

confidence: 90%

“…There was a significant positive correlation with fetal birth weight when HPL levels were assayed ten days before birth (Seppala and Ruoslahti, 1970), and when serial HPL measurements were made after 36 weeks gestation (Letchworth et al, 1971;Spellacy et al, 1971). Saxena et al (1969) concluded that subnormal serum levels will almost invariably be found after 28 weeks in mothers of small-for-dates babies but, provided no sudden decrease occurs, there is unlikely to be serious fetal distress. Spellacy et al (1971) studied 57 women with Rhesus incompatibility.…”

Section: Hpl In Retarded Fetal Growthmentioning

confidence: 98%

“…The remaining patient had cervical incompetence and aborted, although HPL levels had been normal and rising. Saxena et al (1969) also studied patients in the early part of pregnancy and reported low levels in five patients who later aborted. This was in agreement with the work of Singer et al (1970) who reported five patients with low serum HPL levels, all of whom aborted within 20 weeks, and Spona and Janisch (1971) with 48 cases of threatened abortion whose mean HPL levels during the first -and second -trimester were significantly lower than normal.…”

Section: Hpl In the Prediction Of Intrauterine Fetal Death (A) In Thementioning

confidence: 99%

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