Serum phosphorus and calcium levels, and kidney disease progression in immunoglobulin A nephropathy

Yu, Ge-Ping; Cheng, Jun; Jiang, Yan; Li, Xiayu; Chen, Jianghua

doi:10.1093/ckj/sfab002

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…In a Chinese cohort of 957 IgAN patients with a median follow-up of 83 months, univariate Cox regression indicated that higher serum phosphorus levels were associated with disease progression, whereas the risk was attenuated after adjusting for other risk factors [18]. In contrast, our results showed higher levels of serum phosphorus were associated with greater risk of progression after adjustment for potential confounders including age, gender, eGFR, proteinuria, MAP, hemoglobin, Oxford S and T score, which was consistent with another large Chinese cohort study including 2,567 IgAN patients with a median follow-up of 31.90 months [19].…”

Section: Discussionsupporting

confidence: 89%

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Serum Phosphorus Might Be a Predictor of Kidney Disease Progression in IgA Nephropathy

Li,

Lu,

Xie

et al. 2023

Kidney Blood Press Res

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Introduction High serum phosphorus level has been reported to be a risk factor for disease progression in patients with chronic kidney disease. Whereas, its role in IgA nephropathy (IgAN) still remains uncertain. This study aimed to investigate the association between serum phosphorus and progression of IgAN. Methods A total of 247 patients diagnosed with IgAN from 2016.11 to 2019.12 at the First Affiliated Hospital of Xian Jiaotong University were retrospectively enrolled in this study. The association between serum phosphorus with kidney disease progression events, defined as 30% estimated glomerular filtration rate (eGFR) decline and kidney failure, was evaluated using Cox models. Results Serum phosphorus was an independent risk factor for poor renal outcome after adjusting for age, gender, urine protein, MAP, eGFR, hemoglobin, Oxford S and T scores (HR, 2.586; 95% CI, 1.238-5.400, P = 0.011). The addition of serum phosphorus to the reference model containing clinical and pathological variables significantly improved the risk prediction of IgAN progression (C statistic, 0.836; 95% CI, 0.783-0.889) as compared with the reference model (C statistic, 0.821; 95% CI, 0.756-0.886). The ability of serum phosphorus level to predict progression was much stronger in IgAN patients without use of immunosuppression (HR 5.173; 95%CI, 1.791-14.944); P=0.002). Conclusion Higher serum phosphorus levels were independently associated with kidney disease progression in patients with IgAN, especially in those without immunosuppression. The addition of serum phosphorus to clinical and pathological data at the time of biopsy significantly improved risk prediction of IgAN progression.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 61%

Serum Phosphorus Might Be a Predictor of Kidney Disease Progression in IgA Nephropathy

Li,

Lu,

Xie

et al. 2023

Kidney Blood Press Res

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“…With renal disorder development, elevated phosphorus concentrations may cause low circulating calcium concentration by accumulating onto the osseous matter and other tissues. Disturbances in the metabolic pathway of calcium metabolism disorders are characteristic features of chronic kidney disease (40) . In various investigations, the circulating concentration of phosphorus was confirmed as a principal health risk for heart failure and all-cause death in kidney failure patients.…”

Section: Figure 6 Serum Level Of Total Calciummentioning

confidence: 99%

Clinical significance of Osteoprotegerin, Vitamin D, Obestatin and some biochemical variables in Kidney failure Patients

Hamadameen,

Akam Jassim Mustafa,

Parween Abdulsamad Ismail

2023

IJPS

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Chronic kidney disease (CKD) is described as an abnormalities of renal function, existing for a long period of time. By reason of the early grades of Chronic kidney disease can be experiences no symptoms, its premature identification is strenuous. initial stage CRD can cause various complications, such as anemia, matabolyic disorders of bone mineral. The study was done to assess the effect the chronic renal disease stage on the Osteoprotegerin, 1,25 dihydroxyvitamin D, Obestatin levels and some biochemical parameters in patients not undertaken dialysis therapy. In this case-control study fifty-five patients with Kidney failure and fourty healthy people were examined. Circulating concentrations of Osteoprotegerin, 1,25 dihydroxyvitamin D and Obestatin were estimated by ELIZA technique, serum urea, uric acid, total protein and total calciumu were estimated enzymatically using spectrophotometer. Serum concentration of Osteoprotegerin, Obestatin, renal function markers in patients group were higher (328.3±41.68 pg/mL; 15.52±4.28pg/mL; 183.2±10.35 mg/dL; 8.88±0.54 mg/dL; 6.57±0.22 mg/dL) respectively in comparison to the control group (172.6±55.48 pg/mL; 11.64±3.26 pg/mL; 33.45±1.08 mg/dL; 0.95±0.03 mg/dL; 4.35±0.22 mg/dL) respectively. Vitamin D, Total Calcium and Total Proteins level in patients group were lower(24.49±2.53 ng/mL; 8.06±0.18 mg/dL; 6.49±0.12 g/dL) respectively as compared to controls (57.11±12.39 ng/mL; 10.15±0.23 mg/dL; 6.82±0.10 g/dL) respectively. The current study reveals that circulating levels of Osteoprotegerin Obestatin are remarkably linked with the existence of renal failure, the current data identify a high prevalence deficiency and insufficiency of 1,25 dihydroxyvitamin D in patients with moderate and severe Chronic nephropathy.

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“…IgA nephropathy is one of the most common primary glomerular diseases worldwide, and the leading cause of kidney failure requiring kidney replacement therapy [ 1–3 ]. The clinical presentation of in IgAN ranges from a benign incidental condition to progressive kidney failure.…”

Section: Introductionmentioning

confidence: 99%

“…The progression of IgA nephropathy is monitored by the presence of proteinuria, hypertension, changes in glomerular filtration rate (GFR), and Oxford classification MEST-C score [ 4–8 ]. In addition, persistent hematuria and hyperphosphatemia are associated with kidney disease progression in patients with IgA nephropathy [ 1 , 9–11 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma D-dimer as a potential predictor of progression in IgA nephropathy: a cohort study

Yu,

Jiang,

et al. 2023

Renal Failure

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Introduction Coagulation disorders play a key role in chronic kidney disease, and the formation or elevation of plasma D-dimer levels reflects activation of the coagulation system. However, its relationship with the severity and progression of kidney disease in IgA nephropathy (IgAN) remains unclear. Methods We assessed 1818 patients with IgAN diagnosed between 2002 and 2019 at the First Affiliated Hospital, Zhejiang University School of Medicine. Plasma D-dimer levels were measured at the time of the renal biopsy. The association between plasma D-dimer levels and kidney disease progression events, defined as a 50% decline in eGFR and end-stage kidney disease (ESKD), was tested using restricted cubic splines and Cox proportional hazard models. Results The median plasma D-dimer level was 220 (170–388.5) µg/L FEU, which was significantly higher than healthy controls 170 (170–202) µg/L FEU. Plasma D-dimer levels were positively correlated with proteinuria ( r = 0.211, p < 0.001) and serum galactose-deficient IgA1 ( r = 0.226, p = 0.004) and negatively correlated with eGFR (r=-0.127, p < 0.001) and Oxford T ( p < 0.001) and C ( p = 0.004) scores. After a median follow-up of 25.67 (13.03–47.44) months, 126 (6.93%) patients experienced composite kidney disease progression events. Higher plasma D-dimer levels were associated with an increased risk of kidney disease progression events (hazard ratio, 1.73; 95% confidence interval [95% CI], 1.40–2.23) per ln-transformed plasma D-dimer ( p < 0.001), after adjustment for sex, age, proteinuria, Mean arterial pressure (MAP) and Oxford classification scores. In reference to the first tertile of plasma D-dimer, hazard ratios were 1.48 (95% CI, 0.76–2.88) for the second tertile, 3.03 (95% CI, 1.58–5.82) for the third tertile. Conclusions High plasma D-dimer levels were associated with the progression of kidney disease severity in IgA nephropathy.

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Serum phosphorus and calcium levels, and kidney disease progression in immunoglobulin A nephropathy

Cited by 7 publications

References 35 publications

Serum Phosphorus Might Be a Predictor of Kidney Disease Progression in IgA Nephropathy

Serum Phosphorus Might Be a Predictor of Kidney Disease Progression in IgA Nephropathy

Clinical significance of Osteoprotegerin, Vitamin D, Obestatin and some biochemical variables in Kidney failure Patients

Plasma D-dimer as a potential predictor of progression in IgA nephropathy: a cohort study

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