Serum phosphate in older people

Lambert, M. A.; Witham, Miles D.; Sumukadas, Deepa

doi:10.1017/s0959259809990359

Cited by 3 publications

(2 citation statements)

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“…In the review of the literature, abnormalities of phosphate handling and phosphate levels were common in older people and were clinically important in some cases. 19 As well as in specific diseases or conditions, it was reported that serum phosphate (s-phosphate) levels were associated with in-hospital mortality in general hospitalized patients. 20 The level of s-phosphate is one of the most commonly assessed serum measures in hospitalized patients.…”

Section: Introductionmentioning

confidence: 99%

Association Between Low Serum Phosphate Level and Risk of Falls in Hospitalized Patients Over 50 Years of Age: A Retrospective Observational Cohort Study

Jang¹,

Kwon²,

Kim³

et al. 2022

CIA

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Purpose Falls are the leading cause of injury among hospitalized patients, particularly among older patients. We investigated the association between serum phosphate (s-phosphate) levels and the risk of in-hospital falls. Patients and Methods This retrospective observational cohort study included all patients aged over 50 years who were admitted to Yongin Severance Hospital in South Korea between January 2018 and March 2021. Demographic, anthropometric, and biochemical parameters were recorded on admission. S-phosphate levels were classified into three groups: below normal (<2.8 mg/dL), normal (2.8–4.4 mg/dL), and above normal (≥4.5 mg/dL). The normal group was further stratified into tertiles (2.8–3.2, 3.3–3.7, and 3.8–4.4 mg/dL). The incidence of in-hospital falls was compared between the five groups. Logistic regression analyses were performed to assess the association between s-phosphate levels and the incidence of falls during the hospital stay, with clinical factors included as covariates in the multivariable models. Results A total of 15,485 patients (female: 52.1%) with a median age of 70.0 years (interquartile range: 60.0–79.0 years) were included in the analysis, of whom 295 (1.9%) experienced a fall during the hospital stay. The incidence of falls was significantly higher among patients with lower s-phosphate levels, and this relationship also applied among patients with s-phosphate levels within the normal range as well. The association between lower s-phosphate levels and increased risk of falls remained significant in the adjusted analyses. Conclusion A lower s-phosphate level on admission was independently associated with an increased risk of in-hospital falls. Further studies are needed to determine whether the s-phosphate level on admission could improve prediction of the risk of in-hospital falls.

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Section: Introductionmentioning

confidence: 99%

Association Between Low Serum Phosphate Level and Risk of Falls in Hospitalized Patients Over 50 Years of Age: A Retrospective Observational Cohort Study

Jang¹,

Kwon²,

Kim³

et al. 2022

CIA

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“…In a previous study by Scragg et al, it was found that low serum 25(OH)D levels are associated with increased heart rate, systolic blood pressure, and RPP. It was also suggested that low vitamin D status may increase cardiac work in 27,153 participants aged ≥20 years, in the National Health and Nutrition Examination Surveys (NHANES) carried out from 1988 to 1994 and from 2001 to 2006 [47] . Our findings are completely in favor of the two reports.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Vitamin D3 and Calcium Supplementation on Fasting Plasma Glucose, Serum Lipids, Rate Pressure Product and Body Mass Index in Healthy Adults

Nada

2014

Zagazig University Medical Journal

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Aim: to investigate the effect of vitamin D3 replacement on body mass index, blood pressure, pulse rate, fasting plasma glucose and serum lipids, in healthy vitamin D deficient adults. Patients and methods: Twenty-five healthy adult participants (3 males and 22 females) with vitamin D3 deficiency were recruited from the endocrine clinic in a tertiary care hospital in Saudi Arabia. History was taken and clinical examination was done for all participants. Height, weight, sitting blood pressure, and pulse rate were measured. Laboratory investigations in the form of vitamin D3 level, fasting plasma glucose, and lipid profile were measured before the participants received any oral vitamin D3. The same anthropometric and biochemical parameters were measured 9 months after starting vitamin D3 supplementation in the form of oral cholecalciferol. Replacement was given as 4500 units of vitamin D3 drops daily for one month, then 3000 units daily for another month, then 2000 units daily for seven months. This was combined with oral calcium carbonate intake of 500 milligrams daily throughout the nine month study period. Results: Pretreatment serum vitamin D3 level was 9.01±3.2 nanogram/milliliter. A vitamin D3 level of 35.4±6.84 nanogram/milliliter was achieved by the end of the study. A significant reduction in the pulse rate (p=0.000) and the systolic blood pressure was noticed (p=0.002). The diastolic blood pressure did not significantly change (p=0.148).The rate pressure product (RPP) was significantly reduced by the end of the study (p <0.001). The increase in vitamin D3 level was not associated with significant changes in fasting plasma glucose (p=0.184) or any of the measured components of the lipid profile. There was no significant effect on the body mass index (p=0.31). Conclusion: Vitamin D3 replacement is associated with a significant reduction of the pulse rate, the systolic blood pressure and the rate pressure product. This indicates a reduction of the cardiac work which may partially explain the cardioprotective effect of vitamin D3. The body mass index does not significantly change with vitamin D replacement. No significant effect of vitamin D replacement on fasting plasma glucose in healthy adults, who are neither diabetic nor prediabetic. Also, no effect of vitamin D replacement on the lipid profile in the same group of healthy population.

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Refeeding syndrome, delirium and diagnostic greed

Small

O’Keeffe

2016

European Geriatric Medicine

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Serum phosphate in older people

Cited by 3 publications

References 38 publications

Association Between Low Serum Phosphate Level and Risk of Falls in Hospitalized Patients Over 50 Years of Age: A Retrospective Observational Cohort Study

Association Between Low Serum Phosphate Level and Risk of Falls in Hospitalized Patients Over 50 Years of Age: A Retrospective Observational Cohort Study

The Effects of Vitamin D3 and Calcium Supplementation on Fasting Plasma Glucose, Serum Lipids, Rate Pressure Product and Body Mass Index in Healthy Adults

Refeeding syndrome, delirium and diagnostic greed

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