Serum phenylalanine in preterm newborns fed different diets of human milk

Thomaz, Débora Marchetti Chaves; Serafin, Paula O.; Palhares, Durval Batista; Tavares, Luciana Venhofen Martinelli; Grance, Thayana R.S.

doi:10.1016/j.jpedp.2014.02.003

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…The study selection process is shown in the PRISMA flow diagram (Figure 1). During the selection process, 9 studies comparing HMF with BMF were identified, of which 3 were excluded due to different primary outcomes-primary outcome as phenylalanine concentrations, bactericidal action of human milk, and likelihood of requiring parenteral nutrition: 1 study each (21)(22)(23).…”

Section: Resultsmentioning

confidence: 99%

Human Milk–Derived Fortifiers Compared with Bovine Milk–Derived Fortifiers in Preterm Infants: A Systematic Review and Meta-Analysis

Ananthan

Balasubramanian

Rao

et al. 2020

Advances in Nutrition

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This systematic review assessed outcomes after using human milk–derived fortifier (HMF) compared with bovine milk–derived fortifier (BMF) in preterm infants. Six randomized controlled trials (RCTs) were included. Meta-analysis using a random-effects model showed the following results: 1) lower risk of necrotizing enterocolitis (NEC; ≥Stage II) (RR: 0.38; 95% CI: 0.15, 0.95; P = 0.04, I2 = 9%; n = 334, 4 RCTs) and surgical NEC (RR: 0.13; 95% CI: 0.02, 0.67; P = 0.02, I2 = 0%; n = 209, 3 RCTs) in the HMF group; 2) no significant difference in mortality (RR: 0.40; 95% CI: 0.14, 1.15; P = 0.09, I2 = 0%; n = 334, 4 RCTs); 3) lower weight gain in the HMF group [mean difference (MD) = −1.08 g · kg−1 · d−1; 95% CI: −1.96, −0.21 g · kg−1 · d−1; P = 0.02, I2 = 0%; n = 241, 4 RCTs]; 4) no differences for length (MD = −0.11 cm/wk; 95% CI: −0.26, 0.04 cm/wk; P = 0.14, I2 = 68%) and head circumference (MD = −0.02 cm/wk; 95% CI: −0.08, 0.05 cm/wk; P = 0.59, I2 = 23%); and 5) no significant difference in late-onset sepsis (RR: 0.96; 95% CI: 0.56, 1.67; P = 0.90, I2 = 63%; n = 334, 4 RCTs). The beneficial effects of HMF for NEC were no longer significant in sensitivity analyses after excluding studies with high risk of bias. Quality of evidence as per Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis was low to very low, and hence the confidence in these results is low. In summary, fortification of milk in preterm infants with HMF compared with BMF decreased the risk of NEC but was associated with lower weight gain. Given the low quality of evidence, adequately powered and well-designed RCTs without the influence of industry are required in this field.

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Section: Resultsmentioning

confidence: 99%

Human Milk–Derived Fortifiers Compared with Bovine Milk–Derived Fortifiers in Preterm Infants: A Systematic Review and Meta-Analysis

Ananthan

Balasubramanian

Rao

et al. 2020

Advances in Nutrition

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“…La LHM tiene un impacto en el crecimiento y desarrollo del cerebro, y es indispensable para el fortalecimiento del sistema inmunológico del niño, y a la vez el vínculo afectivo madre-hijo 4,5,6,7 .…”

Section: Facultad Ciencias De La Salud Programa De Enfermería Universunclassified

Niveles de cobre y zinc en diferentes etapas de la leche materna y la influencia del estado nutricional de madres lactantes

Suárez-Villa

et al. 2019

Rev. chil. nutr.

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Este trabajo fue recibido el 02 de mayo de 2018. Aceptado con modificaciones: 18 de diciembre de 2018.Aceptado para ser publicado: 22 de marzo de 2019.RESUMEN La leche humana materna tiene una composición única para proporcionar a los recién nacidos todos los nutrientes esenciales como proteínas, grasas, hidratos de carbono, minerales, vitaminas y otras substancias fisiológicamente activas, con el fin de suplir en cantidad y calidad las necesidades calóricas y nutricionales del lactante. El objetivo fue establecer las concentraciones totales de cobre y zinc en la leche materna en sus distintas etapas: calostro, de transición y madura, determinadas espectrométricamente y la influencia del estado nutricional de madres lactantes; estudio descriptivo transversal en madres entre 18 y 35 años, sanas y no fumadoras; los resultados evidencian una disminución en las concentraciones de cobre y zinc a medida que la lactancia va evolucionando, además, el promedio de índice de masa corporal de las madres en período de lactancia reflejaron sobrepeso. Concluimos que el contenido calórico de los oligoelementos de la leche materna es esencial para el crecimiento de los niños por los beneficios nutricionales e inmunológicos que proporciona, por lo que es importante que la madre se encuentre en un estado nutricional adecuado que permita suministrar los requerimientos adecuados al niño para su crecimiento y desarrollo.ABSTRACT Human milk has a unique composition and provides newborns with all essential nutrients such as proteins, fats, carbohydrates, minerals, vitamins and other physiologically active substances, in order to supply in quantity and quality the caloric and nutritional needs of the infant. The objective of this study was to establish the total concentration of copper and zinc in breast milk in its different stages: colostrum, transitional and mature milk, determined spectrometrically and the influence of the nutritional status of nursing mothers. We conducted a descriptive cross-sectional study in healthy non-smoking mothers between 18 and 35 years of age. Lower concentrations of copper and zinc as lactation progressed were observed. The average of body mass index of nursing mothers reflected overweight. We concludes that the caloric content of the trace elements of breast milk is essential for the growth of children because of the nutritional and immunological benefits that it provides, so it is important that the mother has an adequate nutritional state that allows to supply the adequate requirements for the child to grow and develop.

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Serum phenylalanine in preterm newborns fed different diets of human milk

Cited by 2 publications

References 18 publications

Human Milk–Derived Fortifiers Compared with Bovine Milk–Derived Fortifiers in Preterm Infants: A Systematic Review and Meta-Analysis

Human Milk–Derived Fortifiers Compared with Bovine Milk–Derived Fortifiers in Preterm Infants: A Systematic Review and Meta-Analysis

Niveles de cobre y zinc en diferentes etapas de la leche materna y la influencia del estado nutricional de madres lactantes

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