Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Luo, Qing; Li, Xue; Zhang, Lu; Yao, Fangyi; Deng, Zhen; Cheng, Qi; Su, Rigu; Xu, Jianqing; Guo, Yang; Li, Junming

doi:10.3892/mmr.2018.9632

Cited by 18 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous investigations revealed an association between single nucleotide polymorphisms of the PGLYRP1-encoding gene and RA 17 . Furthermore, serum levels of PGLYRP1 were shown to be associated with rheumatoid factor (RF) and ACPA in RA and therefore suggested as a potential biomarker for RA 18 . However, so far, the role of PGLYRP1 in RA is still poorly understood.…”

mentioning

confidence: 99%

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

İnanç

Mumcu

Can

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The triggering receptor expressed on myeloid cells 1 (TREM-1) and peptidoglycan recognition protein 1 (PGLYRP1) are involved in the propagation of inflammatory responses. This study investigated whether serum levels of TREM-1 and PGLYRP1 correlate with periodontitis in rheumatoid arthritis (RA) patients. A total of 154 non-smoking participants with RA (n = 55, F/M: 41/14), Behçet´s disease (BD, n = 41, F/M: 30/11) and healthy controls (HC, n = 58, F/M: 40/18) were recruited. Serum and saliva were collected, the 28-joint disease activity score (DAS-28) was calculated and dental/periodontal measurements were recorded. Serum TREM-1 and PGLYRP1 levels were measured by ELISA and salivary bacterial DNA counts by quantitative polymerase chain reaction. TREM-1 and PGLYRP1 levels were higher in RA (166.3 ± 94.3; 155.5 ± 226.9 pg/ml) than BD (102.3 ± 42.8; 52.5 ± 26.3 pg/ml) and HCs (89.8 ± 55.7; 67.4 ± 37.3 pg/ml) (p < 0.05). In RA, periodontitis was associated with increased TREM-1 and PGLYRP1 levels (p < 0.05), yet in patients under methotrexate TREM-1 levels were lower. TREM-1 correlated with C-reactive protein (CRP) levels, DAS-28 and erythrocyte sedimentation rate, whereas PGLYRP1 positively correlated with CRP. RA patients displayed 3.5-fold higher salivary bacterial DNA counts than HCs. Increased serum TREM-1 levels correlated with PGLYRP1, CRP and DAS-28-ESR in RA patients with periodontitis.

show abstract

mentioning

confidence: 99%

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

İnanç

Mumcu

Can

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Furthering this point, there are reported associations between increased serum PGLYRP-1 and systemic inflammatory conditions in adulthood (e.g. rheumatoid arthritis, cardiovascular disease) (50,51). Notably, PGLYRP-1 and many of the other specific granule proteins are dramatically reduced in serum concentration one week postnatal (32).…”

Section: Discussionmentioning

confidence: 92%

Perinatal Granulopoiesis and Risk of Pediatric Asthma

Turturice

Theorell

Koenig

et al. 2020

Preprint

View full text Add to dashboard Cite

Many perinatal characteristics are associated with risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation were inversely associated with pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutrophil specific granules. Changes in these genes correlated with changes in protein abundance in serum. Umbilical cord blood serum concentration of PGLYRP-1, a specific granule protein, was inversely associated with mid-childhood current asthma and early-teen FEV1/FVCx100. Thus, neutrophil specific granule abundance at birth may predict individual risk for pediatric asthma and pulmonary function in adolescence.

show abstract

“…On the other hand, Pglyrp1, Lbp, and Olr1 are upregulated in diseased mice. In serum samples from SLE patients, it has been reported overexpression of Pglyrp1 [37], a member of the family of bacterial peptidoglycan sensor molecules, and also it was associated with other autoimmune diseases like rheumatoid arthritis [38] Besides, SLE severity is associated with Olr1 [4,39].…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice

et al. 2022

View full text Add to dashboard Cite

Background Several studies have demonstrated the contribution of innate immune cells, including macrophages, in promoting systemic lupus erythematosus (SLE). Macrophages, one of the most abundant cell populations in the peritoneal cavity, are considered multifunctional cells with phenotypic plasticity. However, the functional properties of peritoneal macrophages in steady-state and during the progression of SLE remain poorly defined. Methods and results Using the [NZB × NZW]F1 (BWF1) murine model of SLE, we analyzed the phenotype and function of peritoneal macrophages during the disease’s onset. We found a higher frequency of peritoneal macrophages and B1a cells in BWF1-diseased mice than age-matched controls. Additionally, macrophages from diseased animals expressed lower levels of CD206, MHC-II, and Sirpα. RNAseq analysis identified 286 differentially expressed genes in peritoneal macrophages from diseased-BWF1 mice compared to control mice. Functional experiments demonstrate that peritoneal macrophages from diseased-BWF1 mice secrete higher levels of pro-inflammatory cytokines when activated with TLR7 and TLR9 agonists, and they were less efficient in suppressing the activation and proliferation of peritoneal LPS-activated B cells. These data demonstrate that peritoneal macrophages from BWF1-diseased mice present phenotypic and functional alterations shifting to a more pro-inflammatory state. Conclusions The increase of macrophages with an altered phenotype and function together with the accumulation of B1a cells in the peritoneal cavity of diseased-BWF1 mice may promote the progression of the disease. Advancing awareness of the role and phenotype of peritoneal macrophages in SLE may contribute to a better understanding of these types of diseases and the development of novel therapies.

show abstract

Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Abstract: Peptidoglycan recognition protein-1 (PGLYRP-1

Cited by 18 publications

References 24 publications

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

Elevated serum TREM-1 is associated with periodontitis and disease activity in rheumatoid arthritis

Perinatal Granulopoiesis and Risk of Pediatric Asthma

Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice

Contact Info

Product

Resources

About