Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma

Song, Jaewon; You, Jueng Sup; Jeong, Seung-Yeon; Yang, Seung Nam; Hwang, Il-Tae; Im, Yunjoo; Baek, Heysung; Kim, H. Y.; Suh, Dong In; Lee, H. B.; Izuhara, Kenji

doi:10.1111/all.12599

Cited by 68 publications

(57 citation statements)

References 33 publications

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“…34,35 In our patients with mild-to-moderate asthma, no relationship between lung function or PC 20 was found; however, BALF periostin levels were significantly higher in patients with an ACT score of less than 20 points. Furthermore, we did not find any correlations between periostin levels and asthma inflammatory phenotype.…”

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confidence: 65%

Comparative study of periostin expression in different respiratory samples in patients with asthma and chronic obstructive pulmonary disease

Górska¹,

Maskey-Warzęchowska²,

Nejman-Gryz³

et al. 2016

Polish Archives of Internal Medicine

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124years, further attempts have been made to precisely identify these phenotypes, and this has initiated a search for new reliable biomarkers. Periostin has been found to be a marker for Th2-associated inflammation in patients with asthma. 1This type of inflammation is associated with an increased eosinophil count not only in peripheral blood, but also in bronchoalveolar lavage fluid (BALF).2 Therefore, periostin may be used as a potential predictor of airway eosinophilia. 3IntroductIon Asthma is a chronic inflammatory disease with a complex immunological background. Eosinophils are the main cells involved in asthma-related airway inflammation; however, there is also a significant contribution of neutrophils, lymphocytes, and mast cells. As the type of inflammation has been shown to affect treatment response, determination of asthma inflammatory phenotypes based on the predominant inflammatory cells has been strongly advocated. In recent AbstrActIntroductIon Periostin is considered to be a marker of eosinophilic inflammation in patients with asthma. However, there are no literature data on periostin in patients with chronic obstructive pulmonary disease (COPD).objectIves The aim of the study was to evaluate periostin expression and to compare its concentrations in various materials in patients with mild-to-moderate asthma and COPD, as well as to evaluate the potential association between periostin and clinical features of both diseases. PAtIents And methodsUsing an enzyme-linked immunosorbent assay, we measured periostin concentrations in serum, induced sputum (IS), exhaled breath condensate (EBC), and bronchoalveolar lavage fluid (BALF) as well as periostin expression in bronchial biopsy samples in 24 patients with asthma, 36 patients with COPD, and 12 controls. Correlations between periostin levels in different materials were also analyzed and periostin concentrations were compared between patients with asthma and those with COPD.results Periostin levels were detectable in serum, IS, EBC, and BALF from patients with asthma, COPD, and controls. EBC periostin levels correlated with tissue periostin expression and were significantly higher in asthma than in COPD (P = 0.04). Periostin expression in bronchial mucosa was higher in asthma than in COPD (P <0.001), as well as in asthma and COPD patients compared with controls (P <0.001). No significant correlations between tissue periostin expression and BALF, IS, or serum periostin levels were found. There were no differences in serum, IS, BALF, or EBC periostin concentrations between patients with different phenotypes of both diseases.conclusIons Periostin may be detected not only in serum, IS, and airway tissue samples, but also in EBC and BALF. EBC periostin levels and tissue periostin expression are higher in patients with asthma than in those with COPD. EBC periostin levels may serve as a potential surrogate marker for tissue periostin expression. 125Patients were recruited from an outpatient clinic and included consecutive patients with asthma and COPD who wer...

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confidence: 65%

Comparative study of periostin expression in different respiratory samples in patients with asthma and chronic obstructive pulmonary disease

Górska¹,

Maskey-Warzęchowska²,

Nejman-Gryz³

et al. 2016

Polish Archives of Internal Medicine

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“…8) ng/mL compared to normal concentration in peripheral blood, 71.0 (57.5-80.0) ng/mL, though without a correlation with bronchial eosinophilic inflammation and with FeNO (fractional exhaled nitric oxide) values [36]. A decrease in periostin level has been also noticed after puberty [37].…”

Section: Periostin and Bronchial Asthmamentioning

confidence: 89%

Periostin in bronchial asthma – a brief update

Grigoraș¹,

Lozneanu²,

Grigoraş³

et al. 2017

Arch Clin Cases

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Periostin is an extracellular matrix protein which intervenes in the regulation of angiogenesis, and in tumoral cells proliferation and invasion. Recent studies, mainly experimental models, have demonstrated the intervention of this molecule in asthmatic disease, by eosinophils recruitment, bronchial wall remodeling, and by stimulation of inflammatory cytokines production. Currently, periostin is considered a marker of type 2 inflammation in asthma, being secreted by respiratory epithelial cells triggered by IL-13 and IL-4. Concomitantly, periostin accumulated at the bronchial epithelial-connective tissue interface is involved in fibrogenesis and mucus secretion, in correlation with the intensity of bronchial mucosa eosinophilic inflammatory infiltrate. However, the intimate molecular mechanisms of periostin involvement in the pathogenic pathway of asthmatic diseases is far away from elucidation, further research being necessary to certify its value as a biomarker useful in diagnosis and in establishment of therapeutic schemes in bronchial asthma.

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“…Optimal lung function and well- In our study we could not confirm the previous data [20,39] as we did not detect higher peripheral periostin levels in bronchial asthma (without pregnancy) than in healthy controls. Of note, normal circulating levels of periostin or cut-off values in asthma are not defined yet and different values were considered as elevated in the different studies [20,21,22,24,39]. In the study by Jia et al [21] the median serum level was as low as 24.5 (19.6-30.6) ng/mL in severe uncontrolled, treated asthmatic patients, while the average asthmatic serum level was 92.8 (± 38.4) ng/mL found by Kanemitsu et al [20] and 76.5 (± 35.2) ng/mL found by Kim et al [39], both examining more heterogeneous, smoking and co-morbid populations.…”

Section: Discussionmentioning

confidence: 99%

“…In severe asthma periostin already may influence therapeutic decisions since it can help to choose patients who will respond to anti-interleukin-(IL-)13 treatment [22] or anti IL-5 therapy [23]. Serum periostin levels also correlated with fractional exhaled nitric oxide (FE NO ) and with airway hyperresponsiveness to methacholine and mannitol in asthmatic children [24]. More importantly, high serum periostin in patients with high FE NO was a risk for subsequent asthma exacerbations despite taking high-dose ICS, independent of known risks including low FEV 1 [25].…”

Section: Introductionmentioning

confidence: 99%

Circulating periostin level in asthmatic pregnancy

et al. 2016

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Objective: Asthma often complicates pregnancy and represents a risk for complications.Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy.Methods: Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two pregnant groups were similar (p > 0.05). In AP women periostin correlated negatively with FEV 1 (r = -0.5516) and positively with Raw (r = 0.5535; both p < 0.05).Conclusions: Pregnancy itself increases circulating periostin levels and this elevation is detectable in asthmatic pregnancy as well. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.

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Serum periostin levels correlate with airway hyper-responsiveness to methacholine and mannitol in children with asthma

Abstract: Serum levels of periostin, a new biomarker induced by IL-13, were higher in asthmatic children, and were associated with AHR to methacholine and mannitol.

Cited by 68 publications

References 33 publications

Comparative study of periostin expression in different respiratory samples in patients with asthma and chronic obstructive pulmonary disease

Comparative study of periostin expression in different respiratory samples in patients with asthma and chronic obstructive pulmonary disease

Periostin in bronchial asthma – a brief update

Circulating periostin level in asthmatic pregnancy

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