Serum Pepsinogen Levels Are Correlated With Age, Sex and the Level of Helicobacter pylori Infection in Healthy Individuals

Huang, Rong-gen; Xiao, Hang; Zhou, Bin; Xiao-hua, Song; Zhang, Jue; Wang, Chunmin; Jiang, Yehua; Chen, Daozhen; Huang, Biao

doi:10.1016/j.amjms.2016.08.005

Cited by 19 publications

(23 citation statements)

References 19 publications

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“…previous studies, our study also showed that increasing age was significantly associated with increased PGI and PGII levels [36,37]. However, the increase in PG might not be affected by age alone, but might also be influenced by factors such as gastric inflammation and atrophic gastritis [37].…”

Section: Plos Onesupporting

confidence: 75%

Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

et al. 2020

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Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic analysis. The participants with H. pylori infection had significantly lower pepsinogen I and higher pepsinogen II values, but a lower pepsinogen I/II ratio than participants without the infection (all P < .001). The pepsinogen I and pepsinogen I/II values were significantly higher and lower, respectively, in individuals with atrophic gastritis than in those without (both P < .001). Among uninfected individuals, only the pepsinogen I/II ratio was significantly lower in atrophic individuals. Pepsinogen I/II ratio also were significantly different between disease among H. pylori-positive and H. pylori-negative individuals, suggesting the pepsinogen I/II ratio is a robust biomarker for determining both chronic and atrophic gastritis. The cutoffs for detecting chronic and atrophic gastritis for the pepsinogen I/II ratio were 4.65 and 4.95, respectively. In conclusion, pepsinogen levels are useful biomarker for both chronic gastritis and atrophic gastritis, but they should be used with caution. Population-based validation is

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Section: Plos Onesupporting

confidence: 75%

Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

et al. 2020

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“…Moreover, the prevalence of H. pylori increases with age [6,14,25,43]. Our results also showed a further decrease of PG I at the follow-up in groups with already decreased PG I level at baseline, mostly in age groups > 70 years, thus signaling the continuous progression of mucosal changes.…”

Section: Discussionsupporting

confidence: 64%

“…According to previous research on GC epidemiology, women are less affected than men with the proportion 1.5:2.5 [1,3,14,43]. In our study sample, 68.3% of the participants were women, which could be explained by a higher response rate among women (possibly due to more concern about their health) described in other studies as well [12,18].…”

Section: Discussionmentioning

confidence: 44%

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Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

Sjomina

Pavlova

Daugule

et al. 2018

JGLD

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Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I< 70 ng/ml and PG I/PG II ratio < 3), with strongly decreased (PG I< 30 ng/ml and PG I/PG II ratio < 2), and with normal PG level. Biopsy with H. pylori detection was performed (updated Sydney system).Results: Results from 259 patients were analyzed. Pepsinogens were decreased in 133 (51.4%), H. pylori was positive in 177 (66.0%) cases. Mean age was significantly lower in patients with normal compared to strongly decreased PG level group (52.8 vs. 64.1 years, p<0.001). Prevalence of severe corpus atrophy was higher in the strongly decreased compared to the normal PG test group: 7.0% vs. 0%; the same tendency was noted in the distribution of OLGA stages III-IV – 10.5% and 0.0%, OLGIM stages III-IV – 3.5% and 0%, and low-grade dysplasia – 15.8% and 2.4% (p<0.05). Two cases of gastric cancer were found; both presented decreased PG levels. A strong association between H. pylori eradication and PG ratio dynamics was found (p<0.05).Conclusions: All high-risk lesions were found in the decreased PG test groups; two cancer cases were revealed.However, PG demonstrated low specificity and low value of repeated testing. The value of PG as a sole test for gastric cancer risk is limited.

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“…If any of these biopsy‐based tests produced a positive result, H. pylori infection was defined as being current. To exclude subjects with possible past H. pylori infection, we obtained a blood sample to investigate pepsinogen (PG) I, PG II, and H. pylori serology . If these three H. pylori tests were all negative but PG I/II ratio was ≤3 or H. pylori serology was positive, the subject was defined as having a past H. pylori infection .…”

Section: Methodsmentioning

confidence: 99%

Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication ‐ a prospective study for up to 10 years

Hwang

Kim

Lee

et al. 2017

Aliment Pharmacol Ther

149

114

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Serum Pepsinogen Levels Are Correlated With Age, Sex and the Level of Helicobacter pylori Infection in Healthy Individuals

Cited by 19 publications

References 19 publications

Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study

Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication ‐ a prospective study for up to 10 years

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