Serum pepsinogen and Helicobacter pylori infection—a Japanese population study

Toyoda, Kazuhiro; Furusyo, Norihiro; Ihara, Takeshi; Ikezaki, Hiroaki; Urita, Yoshihisa; Hayashi, Jun

doi:10.1007/s10096-011-1543-0

Cited by 15 publications

(8 citation statements)

References 34 publications

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“…In a recent review, we found the prevalence of atrophy to be high (25% or more) in 5 of 9 studies from Africa, 4 and our serological data are consistent with a high prevalence of atrophy compared to 12% in Finland 21 or 27.6% in Japan. 22 We found no evidence that atrophy is more prevalent in the patients with intestinal type of gastric cancer, which is different from recent work in Germany. 19 Our data suggest that intestinal metaplasia can occur independently of gastric atrophy, whether assessed histologically or serologically.…”

Section: Discussioncontrasting

confidence: 99%

Gastric adenocarcinoma in Zambia: A case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis

et al. 2013

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Background Gastric cancer is a leading cause of cancer deaths worldwide but there are few data from Africa. We have recently observed a trend towards diagnosis in younger patients. Objective To test the hypothesis that HIV may have altered risk factors for acquisition of gastric cancer, in a case-control study in the University Teaching Hospital, Lusaka, Zambia. Methods Cases (n=52) with confirmed gastric adenocarcinoma and controls (n=94) undergoing endoscopy but with no macroscopic gastric pathology. Established risk factors and HIV status were compared. Results HIV status did not differ significantly in cases and controls (Odds Ratio 1·03; 95% CI 0·2–4·3; P=1·00) and seroprevalence in cases was similar to the Zambian population. Smoking, regular alcohol intake, and gastric atrophy were all associated with cancer in univariate and multivariate analysis. H. pylori serology was positive in 84% of patients studied and cagA serology in 66%; neither serological marker was associated with cancer. Atrophy, assessed serologically, was common in cases (57%) and controls (30%). In controls, both smoking and alcohol use were associated with atrophy, and intestinal metaplasia was present in 17% but was not associated with atrophy. Conclusions HIV was not associated with gastric cancer and does not explain the apparent change in age distribution in Zambia. Atrophy was common and was not essential for the development of intestinal metaplasia, suggesting that gastric carcinogenesis in Africa does not always follow the Correa pathway.

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Section: Discussioncontrasting

confidence: 99%

Gastric adenocarcinoma in Zambia: A case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis

et al. 2013

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“… 15 2007–2009 Junior high school students General population Children No 1232 [16–17] Urine RAPIRAN Otsuka Pharmaceutical Co, Tokyo, Japan Domestic 1224 64 5.2 33 Toyoda et al . 47 2004–2007 Residents General population Adults No 1728 57.8 [30–89] Serum JHM-CAP, Kyowa, Medex Co., Ltd., Tokyo, Japan Domestic 1540 923 59.9 34 Tamura et al . 46 2008–2010 Participants of a cohort study General population Adults No 5167 [35–69] Urine Rapiran (Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan) Domestic 5167 1881 36.4 35 Shimoyama et al .…”

Section: Resultsmentioning

confidence: 99%

Changing trends in the prevalence of H. pylori infection in Japan (1908–2003): a systematic review and meta-regression analysis of 170,752 individuals

Wang

Nishiyama

Kikuchi

et al. 2017

Sci Rep

100

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Changing trends in the prevalence of H. pylori infection in the general population over time are thought to be the main driving force behind the declining gastric cancer mortality in Japan. However, whether the prevalence of H. pylori infection itself shows a birth-cohort pattern needs to be corroborated. We performed a systematic review of studies that reported the prevalence of H. pylori infection among Japanese individuals. Meta-regression was conducted in the framework of a generalized additive mixed model (GAMM) to account for heterogeneity in the prevalence of H. pylori infection as a function of birth year. The prevalence of H. pylori infection confirmed a clear birth cohort pattern: the predicted prevalence (%, 95% CI) was 60.9 (56.3–65.4), 65.9 (63.9–67.9), 67.4 (66.0–68.7), 64.1 (63.1–65.1), 59.1 (58.2–60.0), 49.1 (49.0–49.2), 34.9 (34.0–35.8), 24.6 (23.5–25.8), 15.6 (14.0–17.3), and 6.6 (4.8–8.9) among those who were born in the year 1910, 1920, 1930, 1940, 1950, 1960, 1970, 1980, 1990, and 2000, respectively. The present study demonstrated a clear birth-cohort pattern of H. pylori infection in the Japanese population. The decreased prevalence of H. pylori infection in successive generations should be weighed in future gastric cancer control programs.

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“…The decrease of the serum pepsinogen I/II ratio is a marker of atrophic gastritis,43 and H. pylori -induced gastritis progresses to gastric atrophy 44. There was a significant correlation between gastric emptying and pepsinogen I/II ratio in the H. pylori -positive patients with FD 45.…”

Section: Discussionmentioning

confidence: 95%

Effect of Eradication on Functional Dyspepsia

Kim¹,

Park²,

Kim³

et al. 2013

J Neurogastroenterol Motil

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Background/AimsThis study evaluated the effect of Helicobacter pylori eradication on functional dyspepsia (FD), and the relationship between the changes of histological gastritis and FD symptom responses.MethodsA total of 213 FD patients diagnosed by Rome III criteria were consecutively enrolled. H. pylori tests and gastritis grade by the Sydney system were performed before and 1 year after the proton pump based-eradication therapy for 7 days. Serum levels of pepsinogen, and genetic polymorphisms IL-6, IL-8 and IL-10 were investigated.ResultsTotal of 91 patients completed the 1 year follow-up. When the response rate of dyspepsia was compared at 1 year between the non-eradicated group (n = 24) and eradicated group (n = 67), each group showed complete response of 62.5% and 62.7%; satisfactory response (≥ 50%) of 0.0% and 19.4%; partial response (< 50%) of 12.5% and 11.9%; and refractory response of 25.0% and 6.0%, respectively (P = 0.015). In addition, the responder group (complete + satisfactory response) at 1 year showed improvement of activity and chronic inflammation in both the antrum and corpus (all P < 0.001). Multivariate analysis showed that H. pylori eradication (OR, 5.81; 95% CI, 1.07-31.59) and symptom improvement at 3 month (OR, 28.90; 95% CI, 5.29-157.82) were associated with the improvement of dyspepsia at 1 year. Among the successfully eradicated FD patients (n = 67), male (P = 0.013) and higher initial BMI (P = 0.016) were associated with the improvement of dyspepsia at 1 year.ConclusionsH. pylori eradication improved FD symptoms, as well as gastritis at 1 year, suggesting that inflammation mediates FD.

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Serum pepsinogen and Helicobacter pylori infection—a Japanese population study

Cited by 15 publications

References 34 publications

Gastric adenocarcinoma in Zambia: A case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis

Gastric adenocarcinoma in Zambia: A case-control study of HIV, lifestyle risk factors, and biomarkers of pathogenesis

Changing trends in the prevalence of H. pylori infection in Japan (1908–2003): a systematic review and meta-regression analysis of 170,752 individuals

Effect of Eradication on Functional Dyspepsia

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