Serum pentraxin-3 levels at 11 to 14 weeks' gestation: association with maternal and placental characteristics

Baschat, Ahmet; Kasdaglis, Tania; Aberdeen, Graham W.; Turan, Özhan; Kopelman, Jerome; Atlas, Robert; Jenkins, Chuka; Blitzer, Miriam G.; Harman, Christopher

doi:10.1016/j.ajog.2009.05.039

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Previous studies have focused on the level of PTX3 in plasma and/ or vaginal fluid in conditions involving preterm delivery, hypertension disorders of pregnancy, fertility, and fetal growth restriction, and its association with maternal and placental characteristics [10,[13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3 in amniotic fluid as a marker of intra‐amniotic inflammation in women with preterm premature rupture of membranes

Kacerovský

Tošner

Drahosova

et al. 2009

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 99%

Pentraxin 3 in amniotic fluid as a marker of intra‐amniotic inflammation in women with preterm premature rupture of membranes

Kacerovský

Tošner

Drahosova

et al. 2009

Intl J Gynecology & Obste

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“…Several previous studies showed a significant overexpression of PTX3 depending on disease severity in women with preeclampsia [18,19]. Furthermore, when maternal plasma PTX3 levels were measured during the early weeks of pregnancy, subjects who later developed preeclampsia were found to have significantly higher levels than those who did not develop preeclampsia [20, 21, 22]. Therefore, PTX3 may be considered an early marker of placentai dysfunction.…”

Section: Discussionmentioning

confidence: 96%

Increased expression of pentraxin 3 in placental tissues from patients with unexplained recurrent pregnancy loss

Zeybek

Tepeli

Cetin

et al. 2019

Balkan Journal of Medical Genetics

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Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a evolutionarily conserved multimeric pattern recognition receptor involved in the humoral component of the innate immune system. Pentraxin 3 is released when tissue is stressed or damaged, and interacts with many different ligands. Pentraxin 3 exerts a pivotal role both as a regulator and as an indicator of inflammatory response in the pathogenesis of many diseases such as sepsis, vasculitis and preeclampsia. Uncontrolled inflammatory response is considered a major cause of unexplained recurrent pregnancy loss (URPL). We determined the PTX3 messenger ribonucleic acid (mRNA) and protein expression levels in placentai tissues from 50 women with URPL, and made comparison with those in 50 age-matched control subjects. In quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry analyses, PTX3 mRNA and protein levels, respectively, were significantly increased in URPL patients compared with their respective controls (p = 0.0001). Although no significant correlations were identified between PTX3 expression levels and clinical parameters such as maternal age, numbers of previous pregnancy losses, and gestational age at miscarriage, PTX3 mRNA expression was significantly higher in patients with no live births than in women with previous live births (p = 0.0001). Our study suggests that tissue-specific expression of PTX3 is associated with URPL. Further larger studies are required to determine whether PTX3 expression can be used as a biomarker to manage URPL in routine clinical practice.

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Plazentationsstörungen und feto-maternale Erkrankungen

Kaisenberg¹,

Steiner²

2017

Dopplersonographie in Geburtshilfe Und Gynäkologie

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Serum pentraxin-3 levels at 11 to 14 weeks' gestation: association with maternal and placental characteristics

Cited by 4 publications

References 15 publications

Pentraxin 3 in amniotic fluid as a marker of intra‐amniotic inflammation in women with preterm premature rupture of membranes

Pentraxin 3 in amniotic fluid as a marker of intra‐amniotic inflammation in women with preterm premature rupture of membranes

Increased expression of pentraxin 3 in placental tissues from patients with unexplained recurrent pregnancy loss

Plazentationsstörungen und feto-maternale Erkrankungen

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