Serum PCB concentrations in residents of Calcasieu and Lafayette Parishes, Louisiana with comparison to the U.S. population

Wong, Lee-Yang; Uddin, Mohammed S; Turner, Wayman E.; Ragin, Angela D.; Dearwent, Steve M.

doi:10.1016/j.chemosphere.2014.07.073

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Compared with other countries, the exposure level of PCBs in our study population was at a relativly low level [ 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. The plasma concentrations of PCBs were related to the dietary intake pattern of local residents [ 15 , 42 ] and decreased with age [ 43 , 44 ]. This low exposure level to PCBs may be caused by different dietary patterns in different countries as well as the different ages of study subjects ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

Path Analysis Reveals the Direct Effect of PCB28 Exposure on Cognitive Dysfunction in Older Chinese Females

Pan

Zhao

et al. 2022

IJERPH

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Background: Research indicates that exposure to polychlorinated biphenyls (PCBs) can cause neurobehavioral impairments in neonates and adults, but the way specific PCBs’ congeners impact cognition functions at a low exposure level in a real-life co-exposure system remains poorly understood. This study aimed to investigate the association of PCBs burden with cognition function among elderly adults. Methods: Based on the Weitang Geriatric Diseases study (2014–2015), the current study measured the plasma concentrations of six indicator-PCBs by GC-MS/MS and assessed the cognitive dysfunction (CoD) via an Abbreviated Mental Test in 266 participants (ages 61–90). Sequential logistic regression was used to analyze the effects of PCBs on cognition functions. Female participants aged less than or equal to 80 years were selected, and path analysis was used to determine the direct or indirect impacts of co-exposure PCBs on CoD by structural equation modeling. Results: After sequential adjustments to potential confounding factors and correction by the Bonferroni, no statistically significant correlation between PCBs exposure and CoD was found in participants (p > 0.05). However, in the co-exposure system, after controlling for co-exposures and confounders, exposure to PCB28 had a direct effect on CoD in females aged between 61 and 80, with a factor load of 0.670. Conclusions: After adjusting for the co-exposures and confounders, exposure to PCB28 can directly increase the risk of cognitive impairment in older Chinese females.

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