Serum paraoxonase and arylesterase activities in patients with chronic otitis media

Turan, Mahfuz; Üçler, Rıfkı; Aslan, Mehmet; Kalkan, Ferhat; Taşkın, Abdullah; Garça, Mehmet Fatih; Çankaya, Hakan

doi:10.1179/1351000215y.0000000012

Cited by 4 publications

(7 citation statements)

References 37 publications

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Section: Discussionmentioning

confidence: 99%

“…The second study identified was by Turan et al [24] The level of lipid hydroperoxide (LOOH) was investigated in this study in addition to the same parameters used by Baysal et al [12] in their study. Turan et al [24] discovered that serum PON and arylesterase activity was significantly lower, and the LOOH level higher, in patients with COM compared to individuals in their control group. They state that low serum PON1 activity may be considered an indicator of oxidant-antioxidant imbalance, claiming in addition that low serum PON1 activity may have an important role to play in the pathogenesis of COM.…”

Section: Discussionmentioning

confidence: 99%

“…There is a minimal number of studies about oxidant and antioxidant mechanisms in patients with COM extant in the literature. [1,6,12,24] However, that a relationship between oxidative stress and COM exists is noteworthy.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been suggested that oxidative stress is likely to play a role in the pathogenesis of COM, how this could occur has not yet been definitively established. A literature search reveals two studies, one by Baysal et al [12] and one by Turan et al [24] , in which the relationship between PON and COM has been investigated. Both studies evaluated the enzymatic activity of circulating PON in individuals with COM.…”

Section: Introductionmentioning

confidence: 99%

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Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Durmuş¹,

Kurtulgan²,

Bora³

et al. 2019

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Objective: Chronic otitis media (COM) is a multifactorial disorder, the pathogenesis of which has yet to be fully elucidated. Numerous aetiological factors, including genetics, eustachian tube dysfunction, autoimmunity, infection, osteoclastic activity, cytokines, endotoxins, and products of lipid peroxidation resulting from oxidative stress, have been proposed to explain the chronic inflammation w hich l ies a t t he h eart of t he d isorder. The aim of this study is to investigate a possible relationship between the pathogenesis of COM and polymorphism within the paraoxonase 1 (PON1) gene. Methods: We investigated 49 patients admitted to the Otorhinolaryngology Department of Cumhuriyet University and diagnosed with COM between September and November 2017. The control group consisted of 51 healthy individuals. Polymerase chain reaction (PCR) -restriction fragment length polymorphism (RFLP) methods were used to genotype the PON1 Q192R (rs662) polymorphism.Results: When the case and control groups were compared in terms of the existence of PON1 (Q192) polymorphism, there was no statistically significant difference between the groups (p=0.166, p>0.05). When intergroup comparison was performed on the type of PON1 (Q192) polymorphism, there was also no statistically significant difference (p=0.261, p>0.05). Conclusion:The present study is the first known study in which PON1 polymorphism has been examined in cases of COM. The results of our study failed to indicate a statistically significant relationship between PON1 polymorphism and COM. However, it is important to note that the higher rate of 192RR polymorphism within the control group may indicate a protective effect in COM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Durmuş¹,

Kurtulgan²,

Bora³

et al. 2019

ENT Updates

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show abstract

“…Free radicals can attack cell membranes, proteins, and DNA, causing irreparable damage and ultimately cell death. 15,19 ROS, including superoxide radicals and hydroxyl radicals, can deplete cochlear tissues of antioxidant protective molecules. This may allow lipid peroxidation that can increase calcium influx and apoptosis in cells of the cochlea.…”

Section: Discussionmentioning

confidence: 99%

Could edaravone prevent gentamicin ototoxicity? An experimental study

et al. 2016

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Objectives: Clinical application of gentamicin may cause nephrotoxicity and ototoxicity. Our study is the first study to investigate the protective effects of edaravone against the gentamicin-induced ototoxicity. We investigated the protective effect of intraperitoneal (i.p.) edaravone application against gentamicin-induced ototoxicity in guinea pigs. Methods: Fourteen guinea pigs were divided into two equal groups consisting of a control group and a study group. One-hundred sixty milligrams per kilogram subcutaneous gentamicin and 0.3 mL i.p. saline were applied simultaneously once daily to seven guinea pigs in the control group (group 1). One-hundred sixty milligrams per kilogram gentamicin was applied subcutaneously and 3 mg/kg edaravone was applied intraperitoneally once daily for 7 days simultaneously to seven guinea pigs in the study group (group 2). Following the drug application, auditory brainstem response measurements were performed for the left ear on the 3rd and 7th days. Results: Hearing threshold values of the group 1 and group 2 measured in the 3rd day of the study were detected as 57.14 ± 4.88 and 82.86 ± 7.56, respectively. This difference was statistically significant ( p < 0.05). Hearing threshold values of the group 1 and group 2 measured in the 7th day of the study were detected as 87.14 ± 4.88 and 62.86 ± 4.88, respectively. This difference was statistically significant ( p < 0.05). Conclusion: A statistically significant difference between the average threshold values of edaravone-administered group 2 and that of group 1 without edaravone was found. These differences show that systemic edaravone administration could diminish ototoxic effects of gentamicin and the severity of the hearing loss.

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Is otitis media with effusion associated with oxidative stress? Evaluation of thiol/disulfide homeostasis

Şimşek

Bıçer

Mazlumoğlu

et al. 2019

American Journal of Otolaryngology

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Serum paraoxonase and arylesterase activities in patients with chronic otitis media

Abstract: These results indicated that a lower level of PON1 activity was associated with an oxidant-antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM.

Cited by 4 publications

References 37 publications

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Examination of Paraoxonase 1 Gene Polymorphism in Cases with Chronic Otitis Media

Could edaravone prevent gentamicin ototoxicity? An experimental study

Is otitis media with effusion associated with oxidative stress? Evaluation of thiol/disulfide homeostasis

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