“…In addition, epidemiological studies have reported that the serum concentration of PON1 across the general population is highly variable (can vary by 40-fold) (Brophy et al, 2002). PON1 activity is decreased in several pathological conditions (diabetes type II, coronary heart disease, rheumatoid arthritis, hyperthyroidism, Alzheimer, and others), as well as in workers exposed to OPs independently or have a PON1 genetic polymorphism (Mackness et al, 1998;Brophy et al, 2002;Ferr e et al, 2002;Paragh et al, 2002;Tanimoto et al, 2003;Deakin and James, 2004;Costa et al, 2005;S€ ozmen et al, 2007;Araoud et al, 2010;Hofmann et al, 2010;Gbandjaba et al, 2012;Gugliucci et al, 2012;Gungor et al, 2013). In this sense, Younis et al (2014) reported that circulating IL-6, MCP-1 and PON1 levels are influenced by ovarian stimulation.…”