Serum Paraoxonase-1 Activity and the Risk of Prostate Cancer Recurrence in Patients Treated with Radiotherapy

Abstract

The antioxidant paraoxonase-1 (PON1) may be involved in the response to radiation-induced oxidative stress and possibly prevent cell apoptosis. The correlation of PON1 with the risk of cancer recurrence after radiotherapy (RT) is not yet explored. We investigated changes in the activity of PON1 in patients with prostate cancer (PCa) undergoing RT, and the relation of PON1 activity to the risk of recurrence after RT. We included 56 men with PCa. Blood samples were obtained before irradiation and after the completion of RT. Patients were followed for an average of 51.2 months. Each case of biochemical recurrence was confirmed with biopsy. The control group was composed of 60 healthy men. There was no significant difference in PON1 activity between the control group and patients pre-radiotherapy. Irradiation was associated with a significant decrease in PON1 activity. Patients with PCa recurrence had significantly higher serum PON1 activity than those recurrence-free, both before and after RT. PON1 activity was a predictor of PCa recurrence, with sensitivity over 80% and specificity over 64%. Our results suggest that PON1 activity may be a predictor of PCa recurrence risk after RT. Studies with a larger number of patients and longer follow-up are needed to confirm this hypothesis.

Gradient Boosting Machine Identified Predictive Variables for Breast Cancer Patients Pre- and Post-Radiotherapy: Preliminary Results of an 8-Year Follow-Up Study

“…It is possible that the higher PON1 activities in patients who had died reflects, therefore, a lower production of oxidative stress by RT, and a lower efficacy of the treatment; the consequence being a fatal outcome. In agreement with our results, a recent study reported that patients with prostate cancer recurrence had significantly higher post-RT serum PON1 activity than those who were recurrence-free [ 63 ].…”

Modulatory Effect of Lifestyle-Related, Environmental and Genetic Factors on Paraoxonase-1 Activity: A Review

“…Recently, the correlation between PON1 activity with the risk of cancer recurrence after radiotherapy (RT) has been investigated for prostate cancer (PCa) patients [78]. The prospective study has been conducted on 56 men suffering from PCa subjected to RT, among which 11 experienced a recurrence confirmed by biopsy.…”

Investigation of Age-Related Alterations in Brain and Serum Samples in a Healthy Aging Rat Model

“…PON enzymes, especially PON arylesterase are defined to be a critical defense system against lipid peroxidation, and a decrease in activity is a marker of increased systemic oxidative stress (Menini, 2014;Ayada, 2022;. Many clinical and experimental studies report a significant decrease in serum PON arylesterase activity in several pathological conditions such as dementia (Menini, 2014), rheumatoid arthritis (Erre, 2022), coronary artery diseases (Sofflai, 2022), cancer (Elseadya, 2002;Jasinski, 2022;Thompson, 2022), COVID-19 (Gabaldo,2022) and also in a rat model (Dube, 2022).…”