Serum oxidative stress parameters and paraoxonase‐1 in children and adolescents exposed to passive smoking

Kahraman, Feyza Ustabaş; Torun, Emel; Osmanoğlu, Nurcan Keskin; Oruçlu, Şüera; Özer, Ömer Faruk

doi:10.1111/ped.13073

Cited by 14 publications

(9 citation statements)

References 31 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kahraman et al also observed a similar result in their study comprised of 80 children (40 exposed, 40 not exposed, aged 5-17 years). They found that total oxidant status and oxidative stress index were increased in children exposed to secondhand smoke; however, total antioxidant status was similar in both groups [36]. In the light of our results and the literature on this topic, it may be feasible to suggest that passive smoking initially effects oxidant levels, but not antioxidant levels.…”

Section: Discussionsupporting

confidence: 38%

Serum catalase, thiol and myeloperoxidase levels in children passively exposed to cigarette smoke

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background: Free radicals found in cigarette smoke can harm all tissues and cellular structures in the human body. Passive smoking increases free radical production, leads to the depletion of antioxidants and increases oxidative stress which causes lipid peroxidation. Many studies have been conducted to determine the effects of passive smoking on antioxidant enzymes and lipid levels in adults, but pediatric studies on this topic are few. In our study, we compared the levels of antioxidants, oxidants, total and LDL cholesterol in children exposed to passive cigarette smoking with a healthy control group that was not exposed to passive smoking. Methods: A total of 41 children (4-17 years of age, 24 girls and 17 boys) exposed to passive smoking and 18 healthy girls and 12 healthy boys were included in this study. Secondhand smoking was confirmed via measurement of the cotinine/creatinine ratio. Various sociodemographic characteristics of patients were recorded. The levels of catalase, thiol, myeloperoxidase were measured to determine the antioxidant and oxidant levels in children, while the levels of total cholesterol and LDL cholesterol were measured to determine the alterations in lipid profile. Results: The groups were similar in regard to demographic characteristics. Myeloperoxidase levels were significantly higher in the passive cigarette smoking group compared to the non-exposure group; however, catalase and thiol levels were similar. In regard to lipid profile, the levels of total cholesterol and LDL cholesterol were also similar in those with and without exposure to passive smoking. Conclusions: Our findings suggest that the effects of passive smoking initially influence oxidants (MPO), but not antioxidants (thiol and catalase). However, it is apparent that passive smoking adversely affects oxidative balance in children and this may lead to the development of various diseases which could cause significant morbidity and mortality.

show abstract

Section: Discussionsupporting

confidence: 38%

Serum catalase, thiol and myeloperoxidase levels in children passively exposed to cigarette smoke

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Inflammation and oxidative stress (OS) are often considered as pre-pathological conditions originated from numerous non-optimal environments and working circumstances [1], from modifiable habits (e.g., tobacco smoking) [2,3] and from several health impairments which may represent both their cause and effect [4]. Various risk factors are able to induce redox imbalance in humans, and among these, adiposity [5,6] and second hand smoke (SHS) may play an important role in OS induction, in particular in youths [7,8,9]. Indeed, excessive adipose tissue and high exposure to SHS may induce a dysregulation of the balance between oxidants and antioxidants in favor of the oxidants [10,11], leading to OS [12], which determines a condition that often precedes the onset of several diseases [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure

Squillacioti

Bellisario

Grignani

et al. 2019

IJERPH

View full text Add to dashboard Cite

Obesity and exposure to second-hand tobacco smoking (SHS) may influence oxidative stress (OS) levels, especially in children. This study investigated body composition and SHS influence on OS induction in the paediatric population. The first purpose was identifying an appropriate BMI standard for adiposity assessment in OS investigations. Secondly, SHS and obesity were analysed as inductors of OS. The epidemiologic sample involved 330 children. Three BMI (body mass index) references (IOTF, CDC, and WHO) and an impedentiometric scale supplied body-composition measurements. Partecipants filled out a questionnaire and provided urinary samples for biomarker quantifications: isoprostane (15-F2t IsoP) and cotinine as OS and SHS biomarker, respectively. Obesity prevalence changed over different BMI references (14%, 21%, and 34% for IOTF, CDC, and WHO, respectively). Obese children, by IOTF, showed an increase of 56% in 15-F2t IsoP compared to those normal weight (p = 0.020). Children belonging to the third and the fourth cotinine quartile compared to those of the first quartile had higher 15-F2t IsoP (1.45 ng/mg, 95% CI: 1.06–1.97, p = 0.020 and 2.04 ng/mg, 95% CI: 1.55–2.69, p < 0.0001, respectively). Obesity assessment in children requires appropriate BMI reference depending on research field. Both SHS exposure and obesity may increase OS in children.

show abstract

“…We found that PON1 rs662 T allele might decrease the risk of EGJA in ever smoking subgroup, suggesting that PON1 rs662 C>T polymorphism might act as a protective factor for EGJA. Kahraman et al found tobacco exposure increased oxidative stress and decreased paraoxonase-1 [ 33 ]. The coding region PON1 rs662 C>T polymorphism (R192Q) leads to an amino acid substitution and determines a substrate dependent effect on activity.…”

Section: Discussionmentioning

confidence: 99%

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Tang

Liu

Wang³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Esophagogastric junction adenocarcinoma (EGJA) is a serious public health problem with high mortality in China. In this study, we assessed the association between Paraoxonase 1 (PON-1) rs662 C>T, rs854560 A>T polymorphisms and EGJA risk. This case-control study enrolled 2,740 participants of Asians origin from the Eastern Chinese Han populations. SNPscanTM genotyping assay was harnessed to determine the genotyping of PON1 polymorphisms. The PON-1 rs854560 A>T and rs662 C>T genotypes distribution accorded with Hardy-Weinberg equilibrium. We found that there was no difference in the frequency of PON-1 rs662 C>T, rs854560 A>T genotypes between the overall EGJA cases and controls. In the subgroup analyses, the results indicated that PON-1 rs662 C>T polymorphism might be associated with a significantly decreased risk of EGJA in ever smoking group (TT vs. CC/CT: adjusted OR = 0.58, 95% CI 0.35-0.95, P = 0.029). In conclusion, our study highlights PON-1 rs662 C>T polymorphism may decrease the risk of EGJA, which interacts with the tobacco using. In the future, a fine-mapping case-control study with detailed geneenvironmental data is needed to further assess these potential relationship.

show abstract

Serum oxidative stress parameters and paraoxonase‐1 in children and adolescents exposed to passive smoking

Abstract: Secondhand smoke exposure is associated with increased oxidative stress and decreased paraoxonase-1 without any change in antioxidant status.

Cited by 14 publications

References 31 publications

Serum catalase, thiol and myeloperoxidase levels in children passively exposed to cigarette smoke

Serum catalase, thiol and myeloperoxidase levels in children passively exposed to cigarette smoke

The Asti Study: The Induction of Oxidative Stress in A Population of Children According to Their Body Composition and Passive Tobacco Smoking Exposure

Association between Paraoxonase 1 polymorphisms and risk of esophagogastric junction adenocarcinoma: a case-control study involving 2,740 subjects

Contact Info

Product

Resources

About