Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

Kim, S. M.; Lee, J.; Ryu, Ohk Hyun; Lee, K. W.; Kim, Ho Y.; Seo, Ji A; Kim, S. G.; Kim, N. H.; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook

doi:10.1111/j.1365-2265.2005.02390.x

Cited by 71 publications

(61 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…OPG levels increase with age (14,20), diabetes (12,21), and renal failure (22) and are positively correlated with CRP, interleukin-6, fibrinogen, glycemic status, and insulin resistance (17,23,24). In our study, fasting glucose, creatinine, hsCRP, fibrinogen, and HOMA-IR showed significantly positive correlations with OPG.…”

Section: Discussionsupporting

confidence: 53%

Elevated Serum Osteoprotegerin Levels Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Shin

Chung

2006

Diabetes Care

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 53%

Elevated Serum Osteoprotegerin Levels Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Shin

Chung

2006

Diabetes Care

View full text Add to dashboard Cite

“…Besides, in our study, testosterone levels were not retained as a predictive variable in the multivariate analysis. Finally, insulin resistance, another common characteristic of PCOS patients, has been shown to correlate either directly (51) or inversely (20) with serum OPG concentrations, but we did not find any statistically significant relationship between serum OPG levels and the insulin sensitivity index.…”

Section: Discussioncontrasting

confidence: 45%

Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome

Escobar-Morreale

Botella-Carretero

Martínez‐García

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, has a variety of functions including anti-inflammatory effects and a possible cardiovascular protective role. Both low-grade chronic inflammation and cardiovascular risk are increased in women with the polycystic ovary syndrome (PCOS). We aimed to study serum OPG concentrations in PCOS patients. Design: Case-control study including 40 PCOS patients matched with 40 non-hyperandrogenic women for age and body mass index. Methods: Basal serum sampling and standard oral glucose tolerance test, and measurement of serum OPG concentrations by commercial ELISA. Results: Serum OPG concentrations were lower in women with PCOS compared with those of controls (304G120 vs 363G105 pg/ml respectively; FZ7.641, PZ0.007) independently of obesity. No differences were observed in serum receptor activator of nuclear factor-kB ligand (RANKL) levels and in the RANKL/OPG molar ratio. A multivariate linear regression model (R 2 Z0.208, FZ6.579, PZ0.001) showed that PCOS (bZK0.281, PZ0.008), obesity (bZK0.245, PZ0.022) and age (bZ0.296, PZ0.006) were predictive of serum OPG concentrations. Conclusions: Serum OPG concentrations are reduced in PCOS patients independently of obesity. Considering the anti-inflammatory effects of OPG, its reduced serum concentrations might contribute to the proinflammatory state and cardiovascular risk of PCOS patients.European Journal of Endocrinology 159 225-232

show abstract

“…The reason for this association is unclear. Two previous reports (in obese subjects (22) and in elderly men (21)) showed a positive relationship between OPG and insulin sensitivity, while a third one in women found no relationship (20); finally, in a fourth study (30), OPG was positively correlated with HOMA index in normal and diabetic subjects. Results of the present study are in line with this last study and show an independent relationship between HOMA index and OPG.…”

Section: Discussionmentioning

confidence: 91%

“…CRP is an acute-phase protein produced predominantly by hepatocytes under the influence of cytokines. The relationship between CRP and OPG was recently studied in subjects with CAD (18), diabetes (30), and long-lived subjects (32) but has never been looked at in obese subjects. On the other hand, despite the positive relationship that we found in our obese group between OPG and SGPT, SGPT was not found to be an independent predictor of OPG suggesting that, at least in healthy obese subjects, there is no direct relationship between OPG and liver function.…”

Section: Discussionmentioning

confidence: 99%

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Gannagé‐Yared¹,

Yaghi²,

Habre³

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: We analyzed the relation of osteoprotegerin (OPG) with insulin sensitivity, lipid profile, serum glutamic pyruvic transaminase (SGPT), adipocytokines, and C-reactive protein (CRP) in obese and non-obese subjects. Methods: In the study, 170 subjects (106 obese and 64 non-obese, sex ratio female/maleZ2.03) were included. Thirty-two obese subjects were reevaluated 6 months after the weight loss induced by bariatric surgery. Results: OPG did not differ between obese and non-obese subjects (respective mean values 5.17 and 4.96 pmol/l) or according to gender, but was positively correlated with age (P!0.0001 for both groups). OPG was statistically higher in 18 obese diabetic subjects compared with non-diabetics (PZ0.03). After adjustment for age, no significant correlation was found between OPG and body mass index (BMI), waist, systolic and diastolic blood pressure, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, leptin, and adiponectin in both the obese and non-obese subjects. However, OPG was positively correlated with homeostasis model assessment (HOMA) index and SGPT levels in obese subjects at baseline (rZ0.295, rZ0.20, P!0.05) and after adjustment for age (rZ 0.28, rZ0.20, P!0.05). OPG was also significantly correlated with CRP; this correlation persisted after adjustment for age in obese subjects (rZ0.30, P!0.01). In a multivariate analysis in the obese group, HOMA index and CRP were independent predictors of OPG while SGPT was not. Six months post-surgery, OPG did not change, despite a significant reduction in glucose, SGPT, cholesterol, triglycerides, CRP, and leptin values (PZ0.02, PZ0.006, PZ0.007, P!0.001, P!0.001, P!0.001 respectively) and a significant increase in adiponectin and HDL values (P!0.001 for both variables). Conclusion: Our results show that in obese subjects, OPG is not related to BMI. However, we describe new relationships between OPG and both HOMA index and CRP.

show abstract

Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

Abstract: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

Cited by 71 publications

References 33 publications

Elevated Serum Osteoprotegerin Levels Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Elevated Serum Osteoprotegerin Levels Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Serum osteoprotegerin concentrations are decreased in women with the polycystic ovary syndrome

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Contact Info

Product

Resources

About