Serum Osteoprotegerin and Rankl Levels in Chronic Alcoholic Liver Disease

García-Valdecasas-Campelo, Elena; González‐Reimers, Emilio; Santolaria-Fernández, Francisco; Vega-Prieto, Marı́a José de la; Milena-Abril, Antonio; Sánchez-Pérez, María José; Martı́nez-Riera, Antonio; Gómez-Rodríguez, María De Los Ángeles

doi:10.1093/alcalc/agl004

Cited by 67 publications

(33 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In their study Garcia-Valdecasas-Campelo et al showed free testosterone lower (13.62 +/-11.96 pg/ml) in patients than in controls [9]. The mean testosterone levels in our patients was 8,90 umol/l ( ranged: 7,4-10,9 umol/l ) with the normal range interval: 8,2-34,6 umol/l.…”

Section: Discussionsupporting

confidence: 43%

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

et al. 2009

View full text Add to dashboard Cite

AbstractIn the course of cirrhosis, a variety of disturbances of endocrine glands occur. Degenerative changes in the testes with atrophia and fibrosis of the glandular tissue are often found in men. Twenty-one males with compensated alcoholic liver cirrhosis were studied. The age ranged from 29 to 61 years (mean 47,1). Efficiency of the liver was evaluated according to Child classification. HBC (this needs to be spelled out in parenthesis) or HBV (Hepatitis B Virus) infections were excluded. Levels of serum testosterone were determined and the volume size of the testes was measured using 7,5 MHz sector probe, B&K Medical ultrasonograph, 3535 model. Volume size of the testes was measured in 22 healthy control volunteers, as well; age ranged from 25 to 66 years (mean-46,6). All patients were interviewed about sexual function, particularly possible erectile dysfunction using IIEF-5 questionnaire. The mean testosterone level was 8,89 umol/l (ranged: 7,4–10,9 umol/l) in the study patients [the normal range interval: 8,2–34,6 umol/l]. The level was below the normal range in 4 patients, and low but within the normal range in the remaining patients. Statistically significant lower values of both testes volumes were estimated in patients with compensated alcoholic liver cirrhosis in comparison to healthy controls (p<0,001), however only 5 (23,81 %) study group subjects admitted impaired libido and erectile dysfunction. Decreased levels of testosterone in the peripheral blood and diminished volume size of testes are found in patients suffering from alcoholic liver cirrhosis. Erectile dysfunction in patients with liver cirrhosis needs further evaluation.

show abstract

Section: Discussionsupporting

confidence: 43%

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The relationship between OPG and liver function has never been looked at in subjects without liver disease. Conversely, recent studies on patients affected by chronic liver disease have shown increased OPG levels (33)(34)(35). This relationship was not found to be related to decreased bone mineral density (35), suggesting that OPG may be synthesized by the liver as it is assumed by Simonet et al (1).…”

Section: Discussionmentioning

confidence: 90%

“…Conversely, recent studies on patients affected by chronic liver disease have shown increased OPG levels (33)(34)(35). This relationship was not found to be related to decreased bone mineral density (35), suggesting that OPG may be synthesized by the liver as it is assumed by Simonet et al (1). Further studies are probably needed to elucidate the relationship between liver function and OPG values in normal subjects or subjects affected by fatty liver disease.…”

Section: Discussionmentioning

confidence: 91%

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Gannagé‐Yared¹,

Yaghi²,

Habre³

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: We analyzed the relation of osteoprotegerin (OPG) with insulin sensitivity, lipid profile, serum glutamic pyruvic transaminase (SGPT), adipocytokines, and C-reactive protein (CRP) in obese and non-obese subjects. Methods: In the study, 170 subjects (106 obese and 64 non-obese, sex ratio female/maleZ2.03) were included. Thirty-two obese subjects were reevaluated 6 months after the weight loss induced by bariatric surgery. Results: OPG did not differ between obese and non-obese subjects (respective mean values 5.17 and 4.96 pmol/l) or according to gender, but was positively correlated with age (P!0.0001 for both groups). OPG was statistically higher in 18 obese diabetic subjects compared with non-diabetics (PZ0.03). After adjustment for age, no significant correlation was found between OPG and body mass index (BMI), waist, systolic and diastolic blood pressure, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, leptin, and adiponectin in both the obese and non-obese subjects. However, OPG was positively correlated with homeostasis model assessment (HOMA) index and SGPT levels in obese subjects at baseline (rZ0.295, rZ0.20, P!0.05) and after adjustment for age (rZ 0.28, rZ0.20, P!0.05). OPG was also significantly correlated with CRP; this correlation persisted after adjustment for age in obese subjects (rZ0.30, P!0.01). In a multivariate analysis in the obese group, HOMA index and CRP were independent predictors of OPG while SGPT was not. Six months post-surgery, OPG did not change, despite a significant reduction in glucose, SGPT, cholesterol, triglycerides, CRP, and leptin values (PZ0.02, PZ0.006, PZ0.007, P!0.001, P!0.001, P!0.001 respectively) and a significant increase in adiponectin and HDL values (P!0.001 for both variables). Conclusion: Our results show that in obese subjects, OPG is not related to BMI. However, we describe new relationships between OPG and both HOMA index and CRP.

show abstract

“…They have demonstrated that elevated serum OPG and low serum RANKL levels may, in part, represent a compensatory response to the negative balance of bone remodeling in PBC. Recently, Garcia-Valdecasas-Campelo et al [29] have shown high serum levels of OPG with normal levels of RANKL in chronic alcoholic liver disease. They observed negative correlations between OPG and serum albumin and prothrombin activity, indicating a relationship between elevated OPG and deranged liver function.…”

Section: Discussionmentioning

confidence: 99%

Relationships between OPG, RANKL, bone metabolism, and bone mineral density in biliary atresia

et al. 2009

View full text Add to dashboard Cite

show abstract

Serum Osteoprotegerin and Rankl Levels in Chronic Alcoholic Liver Disease

Cited by 67 publications

References 37 publications

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

Total serum testosterone estimation and ultrasonographic volumetric evaluation of testes in patients with alcoholic liver cirrhosis

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

Relationships between OPG, RANKL, bone metabolism, and bone mineral density in biliary atresia

Contact Info

Product

Resources

About