Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease

Tousoulis, Dimitris; Siasos, Gerasimos; Maniatis, Konstantinos; Oikonomou, Evangelos; Kioufis, Stamatios; Zaromitidou, Marina; Paraskevopoulos, Thodoris; Michalea, Stavroula; Kollia, Christina; Miliou, Antigoni; Kokkou, Eleni; Papavassiliou, Athanasios G.; Stefanadis, Christodoulos

doi:10.1016/j.ijcard.2012.05.001

Cited by 111 publications

(87 citation statements)

References 34 publications

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“…[11][12][13][14][15] As for osteopontin, its mean level in our study was 614.2 ng/ml, while in the literature, its levels in patients with chronic kidney disease were reported to be, depending on the study, in the range between 1.71 and 53 ng/ml. [16][17][18][19][20] Of note, cystatin C concentrations were in the range between 0.4 and 2.7 mg/l in our study, which is consistent with existing literature data. Therefore, we were able to calculate eGFR using formulas containing cystatin C concentrations.…”

Section: Discussionsupporting

confidence: 92%

Serum levels of 12 renal function and injury markers in patients with glomerulonephritis

Serwin¹,

Wiśniewska²,

Jesionowska³

et al. 2016

Polish Archives of Internal Medicine

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Section: Discussionsupporting

confidence: 92%

Serum levels of 12 renal function and injury markers in patients with glomerulonephritis

Serwin¹,

Wiśniewska²,

Jesionowska³

et al. 2016

Polish Archives of Internal Medicine

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“…32,36) The present study showed the serum OPG levels to be significantly related to the mCIMT, and thus may be a significant predictor of early carotid atherosclerosis in patients with CAD. Therefore, further studies are necessary to confirm these results.…”

Section: Elevated Opg Levels and Coronary Artery Diseases And Cimtsupporting

confidence: 52%

“…2,10,11,32) However, contradictory evidence does exist; some investigators have shown OPG to not be associated with either calcification Figure 2. OPG levels were found to be significantly and positively related to the ADMA levels (r = 0.191, P = 0.046, A) and the mean CIMT (r = 0.319, P = 0.001, B).…”

Section: Elevated Opg Levels and Coronary Artery Diseases And Cimtmentioning

confidence: 99%

Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease

et al. 2015

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SummaryOsteoprotegerin (OPG) is a soluble glycoprotein belonging to the tumor necrosis factor receptor superfamily and is linked to vascular atherosclerosis and calcification. The carotid intima-media thickness (CIMT) correlates with carotid atherosclerosis and is a significant predictor of cardiovascular events. The OPG levels are associated with the CIMT in coronary artery disease (CAD) patients. However, the pathophysiological mechanisms underlying this pathway remain unclear. We investigated 114 CAD patients (89 men, 25 women; mean age: 68.7 ± 10.3 years) and measured the Gensini score (a marker of the extent of coronary atherosclerosis), the mean CIMT and the plasma levels of OPG and asymmetric dimethylarginine (ADMA; a marker of endothelial function). Early carotid atherosclerosis was defined as a mean CIMT > 1.0 mm. Only 33 of the 114 patients (28.9%) had early carotid atherosclerosis. Patients with early carotid atherosclerosis had higher OPG levels than those without. The OPG levels were found to be significantly associated with ADMA (r = 0.191, P = 0.046) and the mean CIMT (r = 0.319, P = 0.001), but not with the Gensini score. A receiver operating curve analysis revealed the optimal cut-off value of the OPG levels for predicting early carotid atherosclerosis to be 100 pmol/L. A multivariate logistic regression analysis showed OPG ≥ 100 pmol/L to be significantly and independently associated with early carotid atherosclerosis (odds ratio: 2.98, 95% confidence interval: 1.22-7.20, P = 0.017). These data indicate that OPG is significantly associated with endothelial function and predicts early carotid atherosclerosis in patients with CAD. (Int Heart J 2015; 56: 605-612)

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“…Numerous clinical studies have reported a consistent association between serum OPG levels and cardiovascular events and mortality, which suggests a role for OPG as a marker rather than a mediator of atherosclerosis and confirms previous in vivo studies [106,107,108,109,110]. …”

Section: Rankl Antagonistsupporting

confidence: 86%

Anti-Osteoporotic Drugs and Vascular Calcification: The Bidirectional Calcium Traffic

Yavropoulou¹,

Pikilidou

Yovos³

2013

J Vasc Res

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During the last years, numerous epidemiological studies have demonstrated a direct relationship between vascular calcification and low bone mineral density. This observation is in line with experimental data demonstrating the osteogenic characteristics of calcified arteries. Various common risk factors have been suggested to link vascular calcification and bone loss, including aging, estrogen deficiency, vitamin D and K deficiency, diabetes mellitus, renal failure, smoking, chronic inflammation and oxidative stress. Although the underlying pathogenetic mechanisms are not yet clear, current research is focusing on anti-osteoporotic agents that could potentially affect the deposition of calcium in the arterial wall and thus provide an additional therapeutic strategy in elderly osteoporotic women prone to calcific cardiovascular disease.

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Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease

Cited by 111 publications

References 34 publications

Serum levels of 12 renal function and injury markers in patients with glomerulonephritis

Serum levels of 12 renal function and injury markers in patients with glomerulonephritis

Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease

Anti-Osteoporotic Drugs and Vascular Calcification: The Bidirectional Calcium Traffic

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