Serum Omentin-1 in psoriasis

Bakry, Ola Ahmed; Farargy, Shawky El; Ghanayem, Naglaa M; Galal, Somia

doi:10.4103/ijd.ijd_222_17

Cited by 4 publications

(2 citation statements)

References 18 publications

(19 reference statements)

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“…TNF‐α has a primary role in the development of the psoriasis by adjusting the interaction between dendritic cells and antigen‐specific T‐cells, which stimulates T‐cell responses. Furthermore, it increased Th17 responses, which plays an essential part in the psoriasis cytokine network by inducing IL‐23 production from dendritic cells 17 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it increased Th17 responses, which plays an essential part in the psoriasis cytokine network by inducing IL-23 production from dendritic cells. 17 In this study, serum TWEAK grades in candidates with psoriasis vulgaris were compared to control group, as well as their association with PASI score and therapy with NB-UVB phototherapy and MTX.…”

Section: Discussionmentioning

confidence: 99%

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TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate

Hegazy,

El Taieb,

Ibrahim

et al. 2024

J of Cosmetic Dermatology

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BackgroundPsoriasis is an autoimmune disease which has an effect on the joints and skin. Tumor Necrosis Factor‐Like Weak Inducer of Apoptosis (TWEAK) is a multi‐functional cytokine which regulates the cellular processes and has been related to a variation of conditions.ObjectivesTo measure the level of serum TWEAK in psoriatic diseased persons and its relationship to the PASI score pre‐ and post‐therapy with narrowband ultraviolet B phototherapy (NB‐UVB) and methotrexate (MTX).MethodsThis randomized controlled trial was conducted on 40 patients and 20 healthy persons as controls. Patient Group was randomly subdivided to two groups. The 1st group consisted of 20 patients who received NB‐UVB treatment. The 2nd group included 20 MTX‐treated candidates. Blood samples were drawn from patients in order to detect serum TWEAK levels using ELISA. The research was registered on Clinical Trials Registration: RCT approval numbers: NCT0481191.ResultsThe mean PASI score percent improvement after 12 weeks of treatment was higher in the MTX group (90%) than NB‐UVB group (60%). The serum TWEAK level at baseline was 60.47 ± 12.6 pg/mL in NB‐UVB group and 54.69 ± 21.7 pg/mL in MTX group which reduced to 24.93 ± 17.6 pg/mL and 32.13 ± 23.6 pg/mL, respectively (p < 0.001), after 12 weeks of treatment. There was a positive correlation between the serum levels of TWEAK and severity of PASI score (r = 0.399, p = 0.014).ConclusionTWEAK grades in psoriasis are substantially higher than in controls. TWEAK levels were dramatically reduced during NB‐UVB and MTX treatment. TWEAK may have a potential sign for psoriasis diagnosis and prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate

Hegazy,

El Taieb,

Ibrahim

et al. 2024

J of Cosmetic Dermatology

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The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin

Kiełbowski,

Bakinowska,

Bratborska

et al. 2024

Expert Opinion on Therapeutic Targets

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Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review

Krajewski

Matusiak

Szepietowski

2022

British Journal of Dermatology

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Hidradenitis suppurativa (HS) is a chronic, recurrent, debilitating disorder of the pilosebaceous unit. Although its pathophysiology is not fully explained, inflammation seems to play an essential role in the development of HS. A link between obesity – often considered a state of chronic inflammation – and a higher prevalence of HS has been described. Nevertheless, the exact association is not well understood. Adipose tissue is a highly active endocrine organ that produces and secretes a variety of metabolically and immunologically active molecules called adipokines. The imbalances in concentrations of several adipokines in patients with HS have already been described. A shift towards the overproduction of proinflammatory adipokines (including leptin, resistin and visfatin) with the suppression of anti-inflammatory ones (adiponectin) has been noted. We conducted a review of the available data on adipokines in HS, concentrating on the described imbalances in adipokine concentrations, as well as possible implications in HS pathogenesis. Moreover, new, unstudied adipokines with possible implications in the development of HS are proposed.

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Serum Omentin-1 in psoriasis

Cited by 4 publications

References 18 publications

TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate

TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate

The role of adipokines in the pathogenesis of psoriasis – a focus on resistin, omentin-1 and vaspin

Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review

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