Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: A multicenter study

Gumanova, Nadezhda G.; Teplova, N. V.; Ryabchenko, Alexander U.; Денисов, Е. Н.

doi:10.1016/j.clinbiochem.2014.10.010

Cited by 16 publications

(9 citation statements)

References 12 publications

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“…We have recently demonstrated that in a hospital setting with controlled low‐nitrate diet, levels of serum NO x are associated with blood pressure and stroke. In patients who lacked dietary control, these associations were undetectable ( and references therein for similar studies of other authors). It should be also noted that in our study, majority of the patients are taking various classes of antihypertensive medications thus masking possible associations and further complicating the analysis.…”

Section: Discussionmentioning

confidence: 77%

Serum nitrite and nitrate levels, NOx, can predict cardiovascular mortality in the elderly in a 3‐year follow‐up study

et al. 2016

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Nitric oxide (NO) is an important functional regulator that contributes to progression of various cardiovascular diseases. We studied associations between nitric oxide metabolites, nitrite and nitrate (NOx), and cardiovascular mortality in a prospective 3-year follow-up cohort study in 1,869 elderly patients aged over 55 years. The Cox proportional hazard regression model was adjusted for multiple factors including sex, age, risk corresponding to preexisting cardiovascular conditions, and serum inflammatory markers (C-reactive protein, interleukin-6, fibrinogen, and leucocytes count). During the follow-up period, there were a total of 348 deaths including 216 deaths unrelated to cardiovascular events and 132 cardiovascular deaths. Cox regression adjusted for factors related to cardiovascular disease risks and inflammatory markers showed a significant association between high levels of serum nitric oxide metabolites, NOx, and increased cardiovascular mortality (hazard ratio 2.21; 95% confidence interval 1.13-4.31) but there was no association with non-cardiovascular mortality. Analysis of adjusted hazard ratios demonstrates that association of serum nitric oxide metabolites with cardiovascular mortality was independent of levels of inflammatory markers. Thus, elevated concentrations of serum nitric oxide metabolites are a predictor of cardiovascular mortality and may be used as an integral marker of cardiovascular death. © 2016 BioFactors, 43(1):82-89, 2017.

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Section: Discussionmentioning

confidence: 77%

Serum nitrite and nitrate levels, NOx, can predict cardiovascular mortality in the elderly in a 3‐year follow‐up study

et al. 2016

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“…While considering possible use of PBR as a potential biomarker, it is important to compare it to other functional endothelial markers. We have measured levels of stable nitric oxide metabolites, NOx, as they were shown to be linked to regulation of blood pressure in a similar group of patients on a short‐term nitrate‐poor diet . Results presented in Table indicate that serum NOx concentrations exhibit significant negative correlation with systolic, diastolic, and pulse pressure values (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Concentration of NOx was assayed in the deproteinized serum filtered through Spin‐X R UF500 5k molecular weight cutoff concentrators (Corning, UK). Nitrate was reduced to nitrite with vanadium (III) chloride (Sigma) and NOx levels were measured by the Griess reaction as described by Miranda et al with modifications using a microplate reader (Multiscan MCC/340; Labsystems, Finland).…”

Section: Methodsmentioning

confidence: 99%

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall

et al. 2018

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“…In our previous publications, we have demonstrated that high concentrations of serum NOx are independently associated with an increase in cardiovascular mortality in a 3‐year follow‐up study . Moreover, elevated concentrations of NOx can be linked to prevalence of certain non‐infectious diseases including stroke . The main goal of the present work was to assess long‐term prognostic value of NOx towards total and cardiovascular mortality in an 8‐year follow‐up study.…”

Section: Introductionmentioning

confidence: 84%

“…8 Moreover, elevated concentrations of NOx can be linked to prevalence of certain noninfectious diseases including stroke. 9,10 The main goal of the present work was to assess long-term prognostic value of NOx towards total and cardiovascular mortality in an 8year follow-up study. Our data indicate that NOx levels over 70 µmol/L are associated with elevated total and cardiovascular mortality in men but not in women.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8‐year follow‐up study

Gumanova

Деев

Kots

et al. 2019

Eur J Clin Investigation

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Background Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signalling is linked to various cardiovascular diseases. We studied associations between circulating levels of NO metabolites, nitrite and nitrate (NOx) and total and cardiovascular mortality in a prospective 8‐year follow‐up cohort study in 1869 patients aged over 55 years. Materials and methods The Cox proportional hazard ratio (HR) regression models were adjusted for multiple risk‐related variables. Post hoc Kaplan‐Meier survival curves were compared by the Log‐rank test. Results Proportional Cox regression analysis demonstrated that high serum levels of NOx over 70 µmol/L were associated with elevated total mortality (HR 1.4; 95% CI: 1.06‐1.80; P = 0.02) and cardiovascular mortality (HR 1.4; 95% CI: 0.98‐1.98; P = 0.03) when HR was adjusted for age, sex, smoking and urinary creatinine. Additional adjustments for various mortality‐associated baseline comorbidities did not influence associations of elevated NOx with total and cardiovascular mortality. Association of elevated NOx with total mortality persisted in the multivariate regression model combining a number of other characteristics while association of NOx with cardiovascular mortality became non‐significant in the multivariate model. Specific subset of patients contributing to these associations was determined by Kaplan‐Meier survival analysis indicating that cardiovascular and total mortality were increased in men with high serum levels of NOx over 70 µmol/L (Log‐rank test P = 0.01). These associations were not observed in women. Conclusion Elevated concentrations of serum NOx over 70 µmol/L can be used to predict mortality in men over 55 years of age.

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Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: A multicenter study

Cited by 16 publications

References 12 publications

Serum nitrite and nitrate levels, NOx, can predict cardiovascular mortality in the elderly in a 3‐year follow‐up study

Serum nitrite and nitrate levels, NOx, can predict cardiovascular mortality in the elderly in a 3‐year follow‐up study

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall

Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8‐year follow‐up study

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