Serum neutrophil gelatinase‐associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease

Małyszko, Jolanta; Bachórzewska−Gajewska, Hanna; Małyszko, J.; Pawlak, Krystyna; Dobrzycki, Sławomir

doi:10.1111/j.1440-1797.2007.00899.x

Cited by 65 publications

(49 citation statements)

References 24 publications

(35 reference statements)

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“…In our previous study, we reported that hypertensive patients had higher serum NGAL than normotensive ones. [28] The findings that diabetics had significantly higher baseline serum but not urinary NGAL may speak in favor of this explanation. A rise in NGAL, despite nonsignificant changes in creatinine, may be due to renal injury and/or an inflammatory component of NGAL.…”

Section: Discussionmentioning

confidence: 78%

Urinary and Serum Biomarkers after Cardiac Catheterization in Diabetic Patients with Stable Angina and without Severe Chronic Kidney Disease

Małyszko

Bachórzewska−Gajewska

Poniatowski

et al. 2009

Renal Failure

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Background/Aims. Different serum and urinary biomarkers have been recently proposed to serve as markers of acute kidney injury. We tested the hypothesis whether NGAL and other biomarkers could represent an early biomarker of contrast nephropathy (CIN) in diabetic patients with normal serum creatinine undergoing cardiac catheterization in comparison with nondiabetic patients. Methods. Serum, urinary NGAL, cystatin C, urinary kidney injury molecule-1 (KIM-1), interleukin-18 (IL-18), and liver-type fatty acid binding protein (L-FABP) were evaluated before and 2, 4, 8, 24, and 48 hours after cardiac catheterization using commercially available kits. Results. In both groups we found a significant rise in serum NGAL after 2, 4, and 8 hours, and in urinary NGAL and IL-18 after 4, 8, and 24 hours after cardiac catheterization. Serum cystatin C increased significantly 8 hours, reaching peak 24 hours after cardiac catheterization in both groups, and then decreased after 48 hours. L-FABP and KIM-1 increase significantly after 24 and 48 hours after cardiac catheterization. Conclusions. CIN was similarly prevalent in both diabetic and non-diabetic patients undergoing cardiac catheterization. NGAL seems to be a potential early marker for nephrotoxicity and predictor of contrast nephropathy. It is particularly important in the upcoming setting of short-time hospitalizations for cardiac catheterization.

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Section: Discussionmentioning

confidence: 78%

Urinary and Serum Biomarkers after Cardiac Catheterization in Diabetic Patients with Stable Angina and without Severe Chronic Kidney Disease

Małyszko

Bachórzewska−Gajewska

Poniatowski

et al. 2009

Renal Failure

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“…The latter have shown that NGAL can be used as an early biomarker, for example, contrast-induced nep hropathy in patients with normal serum creatinine levels undergoing percutaneous coronary inter ventions, 12 kidney transplant recipients, 13 and hypertensive patients with coronary artery diseases. 14 These results show that NGAL has the potential for detecting kidney injury earlier than either serum creatinine or, perhaps, GFR estimation formulas that use static measurements of serum creatinine. In conclusion, it has been suggested that the discriminating ability of kinetic GFR is equal to that of biomarkers, such as urinary NGAL.…”

Section: Discussionmentioning

confidence: 83%

Untitled

Hekmat

Eshraghi²,

Esmailpour³

et al. 2017

Exp Clin Transplant

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Objectives: Kinetic glomerular filtration rate estimation may have more power and versatility than the Modification of Diet in Renal Disease or CockcroftGault formula for evaluating kidney function when plasma creatinine fluctuates rapidly. After kidney donation, glomerular filtration rate rapidly fluctuates in otherwise healthy patients. We compared 3 formulas for estimating glomerular filtration rate: kinetic, Modification of Diet in Renal Disease, and Cockcroft-Gault, for determining stages of acute kidney injury early after kidney donation. Materials and Methods: In 42 living kidney donors, we measured serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin, and glomerular filtration rates before uninephrectomy and 3 days afterward. To estimate glomerular filtration rate, we used Cockcroft-Gault, Modification of Diet in Renal Disease, and kinetic equations. We sought the most accurate formula for staging acute kidney injury according to the risk, injury, failure, loss, and end-stage criteria. Results: The kinetic glomerular filtration rate model found more cases of stage 3 acute kidney injury than did the Modification of Diet in Renal Disease or Cockcroft-Gault formula. Receiver operating characteristic curves showed that the kinetic glomerular filtration rate model had more sensitivity and specificity than the Cockroft-Gault formula for discriminating among risk, injury, failure, loss, and end-stage criteria stages of acute kidney injury, based on serum creatinine changes. On day 2 after donation, a more sensitive marker with a shorter half-life (serum neutrophil gelatinase-associated lipocalin) was more significantly correlated with kinetic glomerular filtration rate estimation. Conclusions: The kinetic glomerular filtration rate model was able to discriminate stages of acute kidney injury early after kidney donation according to risk, injury, failure, loss, and end-stage criteria better than the Modification of Diet in Renal Disease or CockcroftGault formulas. The kinetic model detected failurestage acute kidney injury ≥ 1 to 2 days earlier than the MDRD formula, CG formula detected no failure.

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“…It has been shown previously that NGAL can be used for the diagnosis of acute renal injury [8,[20][21][22][23][24]. Haase et al showed that NGAL, measured 6 hours after patient admission, can be used as a marker to predict ARF [25].…”

Section: Discussionmentioning

confidence: 99%

Serum Neutrophil Gelatinase-Associated Lipocalin Levels In Early Detection Of Contrast-Induced Nephropathy

Muratoğlu¹,

Kavalcı²,

Kilicli³

et al. 2016

CIM

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Purpose: The purpose of this study was to investigate the role of serum neutrophil gelatinase-associated lipocalin (NGAL) levels in the early detection of contrast-induced nephropathy (CIN).Methods: This prospective study enrolled 74 patients undergoing abdominal tomography with contrast (1 November 2014 -28 February 2015. Demographic properties (age and sex), symptoms and CT examination results were analysed. Sodium, potassium, urea, creatinine and NGAL levels were measured at 0 th , 6 th , and 72 nd hours. P value < 0.05 was considered statistically significant.Results: CIN developed in 16.2% of the study patients. The mean age was significantly higher in the patients who developed CIN (p<0.05). No significant correlation existed between the occurrence of CIN and patient gender (p>0.05). Urea levels did not differ significantly between the groups at 0 th and 6 th hours (p>0.05) but was significantly higher in the patients with CIN at 72 nd hour (p<0.05). Urea levels did not change significantly over time in the entire group (p>0.05). Creatinine level was not significantly different between the groups (p>0.05) but increased significantly over time (p>0.05). There were no significant differences between the groups with respect to NGAL levels at 0 th and 72 nd hours (p>0.05) whereas the group with CIN had a significantly higher NGAL level at 6 th hour (p<0.05). A NGAL level of 668 mg/dL at 6 th hour had a sensitivity of 100%, specificity of 95%, positive predictive value of 80% and negative predictive value of 100% for the detection of CIN.Conclusion: NGAL may be a useful marker for the early detection of CIN.

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Serum neutrophil gelatinase‐associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease

Cited by 65 publications

References 24 publications

Urinary and Serum Biomarkers after Cardiac Catheterization in Diabetic Patients with Stable Angina and without Severe Chronic Kidney Disease

Urinary and Serum Biomarkers after Cardiac Catheterization in Diabetic Patients with Stable Angina and without Severe Chronic Kidney Disease

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Serum Neutrophil Gelatinase-Associated Lipocalin Levels In Early Detection Of Contrast-Induced Nephropathy

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