Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease

Zhu, Hong; Qian, Yuying

doi:10.1177/0300060517748842

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Early accurate diagnosis and effective treatment are very important to improve the prognosis of CRF patients. Previous diagnosis of CRF relied on serum creatinine (Scr), serum uric acid (SUA), blood urea nitrogen (BUN), and other renal function indexes, which often require kidney injury to account for more than half of the organ [4,5] and is adverse to clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Serum Cystatin, Chemokine, and Gastrin-Releasing Peptide Precursors and Their Clinical Value in Patients with Chronic Renal Failure

Liu

Cai

et al. 2022

BioMed Research International

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Objective. To investigate the serum cystatin (CysC), Chemerin, and gastrin-releasing peptide precursor (ProGRP) levels in patients with chronic renal failure (CRF). Methods. CRF patients admitted to our hospital from February 2019 to July 2019 were selected as the observation group, and 50 healthy patients were selected as the control group. The serum levels of CysC, Chemerin, ProGRP, and Scr of all subjects were detected. Patients with CRF were admitted for peritoneal dialysis (PD) treatment for 1 week, and continued treatment was performed. The survival rate of patients with CRF in nearly 1 year after continuous treatment was observed. Multivariate analysis of factors affecting survival time of CRF patients undergoing peritoneal dialysis was performed. The results were compared with those in the health group. The expression levels of CysC, Chemerin, ProGRP, and Scr in the observation group were all decreased, and the differences were statistically significant ( P < 0.05 ). Pearson correlation analysis showed that Scr expression in CRF patients is positively correlated with CysC, Chemerin, and ProGRP ( P < 0.001 ). The survival rate of 98 patients with CRF was 80.61% (79/98), and the mortality rate was 19.39% (19/98). Serum levels of CysC, Chemerin, ProGRP, and Scr in the death group are all higher than those in the survival group, and the differences are statistically significant ( P < 0.05 ). CysC, Chemerin, ProGRP, and Scr are independent risk factors affecting survival time ( P < 0.05 ). The AUC aspects of serum CysC, Chemerin, ProGRP, and Scr in predicting the survival rate of CRF patients in the treatment phase are 0.840, 0.775, 0.782, and 0.725, respectively. Conclusion. The serum levels of CysC, Chemerin, and ProGRP of CRF patients are abnormally elevated and are positively correlated with serum Scr of patients, which can be used as a reliable indicator of pathogenesis and prognosis assessment of CRF patients.

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Section: Introductionmentioning

confidence: 99%

Serum Cystatin, Chemokine, and Gastrin-Releasing Peptide Precursors and Their Clinical Value in Patients with Chronic Renal Failure

Liu

Cai

et al. 2022

BioMed Research International

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“…However, both Cockcroft‐Gault estimation and creatinine‐based methods may be inaccurate in quantifying GFR, resulting in overestimation or underestimation of GFR 28 . Cystatin C in circulation is considered to be a good marker of renal function 29,30 . In people with normal EGFR, elevated cystatin C levels increase the risk of all‐cause death 31 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of cystatin C in patients with acute coronary syndrome: A systematic review and meta‐analysis

Sun

Lü

Xin

2020

Eur J Clin Investigation

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Background Circulating cystatin C has been considered as an independent predictor of cardiovascular and all‐cause mortality in the general population. The purpose of this study was to evaluate the prognostic value of baseline circulating cystatin C levels in patients with acute coronary syndrome (ACS) through meta‐analysis. Methods Prospective studies about the relationship between the level of cystatin C and the prognosis of ACS patients were searched on PubMed, Web of science, Cochrane Library and Embase databases from the establishment of the databases to July 2020. The prognostic values included in this analysis covered all‐cause mortality, major adverse cardiovascular events (MACE) and recurrent myocardial infarction. The effect index between cystatin C level and ACS risk was carried out by hazard ratio (HR). Stata 15.0 software was used for statistical analysis. The quality of the included literature was evaluated according to Newcastle‐Ottawa Scale (NOS). Results A total of 10 studies were included in this meta‐analysis. The results showed that high cystatin C levels significantly predicted the all‐cause mortality of ACS, HR = 2.53 (95%CI: 1.72 ~ 3.72). High cystatin C level significantly predicted MACE of patients with ACS, HR = 3.24 (95%CI: 1.30 ~ 8.07). However, it had no significant predictive significance for recurrent myocardial infarction, HR = 1.71 (95%CI:0.99 ~ 2.97). Conclusion Our meta‐analysis showed that high cystatin C levels were significantly associated with the death risk and MACE in ACS patients. Therefore, cystatin C can be included in the risk stratification model to guide the treatment of high‐risk ACS patients.

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“…The number of CIN-induced acute kidney injury (AKI) cases accounts for 11 percent of the total number of AKI cases. CIN refers to the iatrogenic renal function damage induced by contrast media, but it has elusive pathogenesis and no specific diagnosis or treatment method [1][2][3] . Early clinical diagnosis is the key to CIN prevention, which can significantly improve the prognosis of patients in combination with appropriate therapies.…”

Section: Introductionmentioning

confidence: 99%

Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention for early diagnosis of contrast-induced nephropathy

Luo,

Ao,

Xiang

et al. 2023

Afr H. Sci.

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Objective: Serum creatinine (SCr) is not a sensitive and reliable index for the early diagnosis of acute kidney injury caused bycontrast-induced nephropathy (CIN). The aim of this study was to explore the values of serum neutrophil gelatinase-associatedlipocalin (NGAL) and cystatin C (Cys-C) after percutaneous coronary intervention (PCI) for the early diagnosis of CIN. Methods: Three hundred patients receiving PCI from January 2018 to December 2020 were assigned to a CIN group (n=25)and a non-CIN group (n=275), respectively. SCr, Cys-C and NGAL levels were measured, and their sensitivities for early CINdiagnosis were evaluated by the area under the receiver operating characteristic curve (AUC) values. Results: The NGAL and Cys-C levels of the CIN group began to rise 6 and 12 h after operation, respectively (P<0.05). TheCIN group had higher NGAL and Cys-C levels than those of the non-CIN group 12, 24 and 48 h after operation (P<0.05). TheAUC values of NGAL, Cys-C and SCr 24 h after operation were 0.885, 0.874 and 0.856, respectively. Conclusion: The serum NGAL and Cys-C levels of patients after PCI reflect the early changes of renal function, which arevaluable for early CIN diagnosis. Keywords: Contrast; cystatin C; nephropathy; neutrophil gelatinase-associated lipocalin; percutaneous coronary intervention.

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Serum neutrophil gelatinase-associated lipocalin and cystatin C are diagnostic markers of renal dysfunction in older patients with coronary artery disease

Cited by 5 publications

References 36 publications

Serum Cystatin, Chemokine, and Gastrin-Releasing Peptide Precursors and Their Clinical Value in Patients with Chronic Renal Failure

Serum Cystatin, Chemokine, and Gastrin-Releasing Peptide Precursors and Their Clinical Value in Patients with Chronic Renal Failure

Prognostic value of cystatin C in patients with acute coronary syndrome: A systematic review and meta‐analysis

Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention for early diagnosis of contrast-induced nephropathy

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